Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Richard Humbert"'
Autor:
Charles E. Murry, Joshua M. Akey, Andrew B. Stergachis, John A. Stamatoyannopoulos, Richard Sandstrom, Sharon L. Paige, Robert E. Thurman, Shane Neph, Eric Haugen, Brady Miller, Benjamin Vernot, Shelly Heimfeld, Alex Reynolds, Richard Humbert, Jeffrey B. Cheng
Publikováno v:
Cell. 154(4):888-903
SummaryCellular-state information between generations of developing cells may be propagated via regulatory regions. We report consistent patterns of gain and loss of DNase I-hypersensitive sites (DHSs) as cells progress from embryonic stem cells (ESC
Autor:
Licia Selleri, Thalia Papayannopoulou, Robert E. Thurman, Sandra Stehling-Sun, R. Scott Hansen, Douglas Dunn, Eric Rynes, Alexander Y. Rudensky, Mark Groudine, Rajinder Kaul, Audra K. Johnson, Arthur I. Skoultchi, Richard Sandstrom, Peter J. Sabo, Morgan Diegel, Marella F. T. R. de Bruijn, Daniel Bates, Steven Z. Josefowicz, Evan E. Eichler, Jeff Vierstra, Michaël Bender, Eric Haugen, Piper M. Treuting, Rachel Byron, Robert M. Samstein, Theresa K. Canfield, Miaohua Zhang, Matthew S. Wilken, Erika Giste, Kai Hsin Chang, Shinny Vong, Stuart H. Orkin, Fidencio Neri, Kristen Lee, Richard Humbert, Thomas A. Reh, John A. Stamatoyannopoulos
Publikováno v:
Vierstra, J; Rynes, E; Sandstrom, R; Zhang, M; Canfield, T; Scott Hansen, R; et al.(2014). Mouse regulatory DNA landscapes reveal global principles of cis-regulatory evolution. Science, 346(6212), 1007-1012. doi: 10.1126/science.1246426. UCSF: Retrieved from: http://www.escholarship.org/uc/item/3hh233xj
Science (New York, N.Y.), vol 346, iss 6212
Science (New York, N.Y.), vol 346, iss 6212
© 2014 by the American Association for the Advancement of Science; all rights reserved. To study the evolutionary dynamics of regulatory DNA, we mapped >1.3 million deoxyribonuclease I-hypersensitive sites (DHSs) in 45 mouse cell and tissue types, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45833cb70075af1e58eb4d7be4358038
https://ora.ox.ac.uk/objects/uuid:db4c1d75-7682-4e65-8ea3-e600e7d57604
https://ora.ox.ac.uk/objects/uuid:db4c1d75-7682-4e65-8ea3-e600e7d57604
Autor:
Hongzhu Qu, Peter J. Sabo, Steven F. Ziegler, Ian A. Glass, Rajinder Kaul, Shelly Heimfeld, Shamil R. Sunyaev, Eric Rynes, Jennifer A. Brody, Tanya Kutyavin, R. Scott Hansen, Chris Cotsapas, Daniel Bates, Robert E. Thurman, Matthew T. Maurano, Shane Neph, Anthony Shafer, Sandra Stehling-Sun, Nona Sotoodehnia, Eric Haugen, Fidencio Neri, Theresa K. Canfield, Erika Giste, Richard Sandstrom, Morgan Diegel, Antony Raubitschek, Hao Wang, Audra K. Johnson, Kristen Lee, Alex Reynolds, Richard Humbert, John A. Stamatoyannopoulos
Publikováno v:
Science. 337:1190-1195
Predictions of Genetic Disease Many genome-wide association studies (GWAS) have identified loci and variants associated with disease, but the ability to predict disease on the basis of these genetic variants remains small. Maurano et al. (p. 1190 ; s
Autor:
Vishwanath R. Iyer, Lingyun Song, Michael O. Dorschner, Joshua M. Akey, Andrew B. Stergachis, Kristen Lee, Anthony Shafer, Shinny Vong, Amartya Sanyal, Hongzhu Qu, Audra K. Johnson, Ericka M. Johnson, Kavita Garg, Minerva E. Sanchez, Daniel Bates, Benjamin Vernot, George Stamatoyannopoulos, Tanya Kutyavin, Robert E. Thurman, Patrick A. Navas, Douglas Dunn, Eric Rynes, Bryan R. Lajoie, Matthew T. Maurano, Jeff Vierstra, Molly Weaver, Jason D. Lieb, Sam John, Alexias Safi, Lisa Boatman, Shane Neph, Zhancheng Zhang, Yongqi Yan, Bum Kyu Lee, Dimitra Lotakis, Zhuzhu Zhang, Gregory E. Crawford, Tristan Frum, Abigail K. Ebersol, Richard Sandstrom, Theresa K. Canfield, Eric Haugen, Erika Giste, Job Dekker, Muneesh Tewari, Alex Reynolds, Eric D. Nguyen, Fidencio Neri, Richard Humbert, Peter J. Sabo, Morgan Diegel, John A. Stamatoyannopoulos, Vaughn Roach, Hao Wang, Rajinder Kaul, Terrence S. Furey, Nathan C. Sheffield, R. Scott Hansen, Jeremy M. Simon, Shamil R. Sunyaev, Boris Lenhard, Darin London
Publikováno v:
Nature
DNase I hypersensitive sites (DHSs) are markers of regulatory DNA and have underpinned the discovery of all classes of cis-regulatory elements including enhancers, promoters, insulators, silencers and locus control regions. Here we present the first
Autor:
Michael J. MacCoss, Mark Groudine, Molly Weaver, Tanya Kutyavin, John A. Stamatoyannopoulos, Shane Neph, Daniel Bates, Eric Rynes, Benjamin Vernot, Douglas Dunn, Anthony Schafer, Joshua M. Akey, Peter J. Sabo, Jeff Vierstra, Robert E. Thurman, R. Scott Hansen, Andrew B. Stergachis, Rajinder Kaul, Shinny Vong, Alex Reynolds, Theresa K. Canfield, Richard Humbert, Erika Giste, Jun Neri, Michaël Bender, Miaohua Zhang, Kristen Lee, Rachel Byron, Richard Sandstrom, Sam John, Eric Haugen, Gayathri Balasundaram, Vaughn Roach, Morgan Diegel, Hao Wang, Audra K. Johnson, Matthew T. Maurano
Publikováno v:
Nature
Regulatory factor binding to genomic DNA protects the underlying sequence from cleavage by DNase I, leaving nucleotide-resolution footprints. Using genomic DNase I footprinting across 41 diverse cell and tissue types, we detected 45 million transcrip
Autor:
Richard Humbert
Publikováno v:
The Physics Teacher. 48:169-172
A force acting on just part of an extended object (either a solid or a volume of a liquid) can cause all of it to move. That motion is due to the transmission of the force through the object by its material. This paper discusses how the force is dist
Autor:
Patrick A. Navas, Richard Humbert, Michael A. Singer, Andrew Haydock, Michael Hawrylycz, Anthony Shafer, Peter J. Sabo, Fidencio Neri, John A. Stamatoyannopoulos, Ericka M. Johnson, Brett E. Johnson, Man Yu, Michael S. Kuehn, Elizabeth Rosenzweig, Jeff Goldy, Robert E. Thurman, Hua Cao, Kristin Lee, Molly Weaver, Michael O. Dorschner, Todd Richmond, William Stafford Noble, Michael McArthur, Roland Green
Publikováno v:
Nature Methods. 3:511-518
Localized accessibility of critical DNA sequences to the regulatory machinery is a key requirement for regulation of human genes. Here we describe a high-resolution, genome-scale approach for quantifying chromatin accessibility by measuring DNase I s
Autor:
Richard Humbert
Publikováno v:
The Physics Teacher. 43:604-607
Autor:
Robert O. Hall, John A. Stamatoyannopoulos, Michael O. Dorschner, Richard Humbert, James C. Wallace, Joshua Mack, Michael Hawrylycz, Anthony Shafer, Peter J. Sabo, Janelle Kawamoto, Man Yu, Michael McArthur
Publikováno v:
Proceedings of the National Academy of Sciences. 101:16837-16842
We developed a quantitative methodology, digital analysis of chromatin structure (DACS), for high-throughput, automated mapping of DNase I-hypersensitive sites and associated cis-regulatory sequences in the human and other complex genomes. We used 19
Autor:
Jonathan H. Dennis, Michael Brudno, Anindya Dutta, Richard M. Myers, Ian Dunham, Eduardo Eyras, S. S. Marticke, Alexandre Reymond, Anason S. Halees, Greg Schuler, M. G. Rosenfeld, Mikhail Nefedov, Robert E. Kingston, Elizabeth Anton, Tyra G. Wolfsberg, Alice C. Young, Kris A. Wetterstrand, C. K. Glass, Nancy F. Hansen, Gayle K. Clelland, Diane I. Schroeder, Jean L. Chang, H. Shin, Zhou Zhu, Nigel P. Carter, William Stafford Noble, Jenny McDowell, Ugrappa Nagalakshmi, Heike Fiegler, Philipp Kapranov, Peggy J. Farnham, Joanna C. Fowler, S. C. Harvey, Michael O. Dorschner, D. R. Inman, George V. Popescu, Jan-Jaap Wesselink, P. Groth, Baoli Zhu, H. Hirsch, James C. Wallace, Elise A. Feingold, S. Jin, Gabriel Robins, Thomas R. Gingeras, F. Denoeud, W. Tongprasit, Robert Castelo, Ross C. Hardison, John A. Stamatoyannopoulos, Joel Rozowsky, Eric A. Stone, Zheng Lian, J. E. Norton, Y. S. Kwon, Viktor Stolc, Michael C. Pirrung, Min-Feng Yu, A. Yang, W. J. Kent, Peter J. Sabo, Stephen Hartman, Stylianos E. Antonarakis, Tae Hoon Kim, H. Kim, Baishali Maskeri, Thomas Royce, R. Luna, Sherman M. Weissman, Tim Hubbard, Oliver M. Dovey, Ewan Birney, Kate R. Rosenbloom, Robert M. Andrews, Damian Keefe, Arend Sidow, D. Zhou, Jane Grimwood, Ulas Karaoz, Zhiping Weng, H. Burden, Michael C. Zody, Hiram Clawson, Gerry Bouffard, S. van Calcar, Mark Dickson, Kevin Struhl, Ingeborg Holt, Emmanouil T. Dermitzakis, T. J. Vasicek, Peter J. Good, Charles R. Cantor, Hari Tammana, Josée Dostie, Prachi Shah, Elliott H. Margulies, Peter D. Ellis, Mark S. Guyer, Christopher M. Taylor, Patrick A. Navas, Dione Kampa, Colin N. Dewey, Lior Pachter, Christof Koch, George Asimenos, James R R Whittle, Gregory E. Crawford, Jane B. Lian, Pamela J. Thomas, Kazutoyo Osoegawa, Webb Miller, Chunxu Qu, Nele Gheldof, Keith D. James, Sandeep Patel, Todd Richmond, Jacquelyn R. Idol, Michael A. Singer, Tomoko M. Tabuchi, Adam Siepel, Yutao Fu, David Vetrie, Long H. Nguyen, Michael Snyder, William H. Majoros, Michael R. Brent, Nathan D. Trinklein, Leah O. Barrera, Mark Gerstein, Srinka Ghosh, Sara J. Hartman, Jade P. Vinson, C. L. Middle, Sambath Chung, George Stamatoyannopoulos, Y. Nakayama, George M. Church, Job Dekker, Olof Emanuelsson, Julien Lagarde, Roderic Guigó, Marco A. Marra, Jeremy Schmutz, Daryl J. Thomas, Yong Yu, M. R. McCormick, Xiang-Dong Fu, Richard Humbert, Jennifer L. Ashurst, Alexander E. Urban, Sarah Wilcox, Ghia Euskirchen, Michael Kamal, Cordelia Langford, Jacquie Schein, Gregory M. Cooper, Paul Bertone, Eric S. Lander, C. Ding, Antonio Piccolboni, Steven L. Salzberg, Rhonda Harrison, Matthew J. Oberley, E. A. Sekinger, Mihaela Pertea, Bing Ren, H. K. Kim, Roland Green, Shelley Force Aldred, Laura Elnitski, Michael Hawrylycz, Andrew J. Mungall, Kerstin Lindblad-Toh, David B. Jaffe, Andreas D. Baxevanis, L. Liefer, Michele Clamp, David Haussler, Jill Cheng, John L. Rinn, S. Kamholz, Vicki L. Wraight, H. Sethi, Francis S. Collins, Steven J.M. Jones, Serafim Batzoglou, P. J. De Jong, Matthew E. Portnoy, Stefan Bekiranov, M. McArthur, Shu-Jin Luo, Eric D. Green, Robert W. Blakesley, Tarjei S. Mikkelsen, Z. Ye, Pawandeep Dhami, Neerja Karnani
Publikováno v:
Science. 306:636-640
The ENCyclopedia Of DNA Elements (ENCODE) Project aims to identify all functional elements in the human genome sequence. The pilot phase of the Project is focused on a specified 30 megabases (∼1%) of the human genome sequence and is organized as an