Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Richard Heys"'
Autor:
Rebecca Urbanek, J. Richard Heys, Peter N. Dorff, Timothy Blake, Scott W. Landvatter, James E. Hall, Charles S. Elmore, Mark E. Powell, Glen Ernst, John R. Harding, David A. Killick
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 57:342-349
In support of a program to develop an alpha 7 agonist as a treatment for Alzheimer's disease, three drug candidates, 1, 2, and 3, were prepared in labeled forms. Compound 1 was prepared in C-14 labeled form by lithiation of [2,6-(14)C2]2-chloropyridi
Autor:
Yuchuan Wang, Robert F. Dannals, Holmquist Christopher, J. Richard Heys, Daniel P. Holt, Eifion Phillips, Ronnie C. Mease, Catherine A. Foss, Hayden T. Ravert, Martin G. Pomper, Hong Fan, Christopher J. Endres, Peter N. Dorff, Dennis J. McCarthy
Publikováno v:
Nuclear Medicine and Biology. 40:731-739
Introduction The alpha-7 nicotinic acetylcholine receptor (α7 nAChR) is key in brain communication and has been implicated in the pathophysiology of diseases of the central nervous system. A positron-emitting radioligand targeting the α7 nAChR woul
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 53:787-792
Clozapine has been demonstrated to bind covalently to proteins as a result of metabolic activation that has been proposed to be a precursor to the serious side effects including death that occur in a small percentage of the population. The covalent m
Autor:
David Gurley, Lois Ann Lazor, Herbert Barthlow, Mike A. Mallamaci, Rich A. Keith, J. Richard Heys, Eifion Phillips, John C. Gordon
Publikováno v:
European Journal of Pharmacology. 645:63-69
AZ11637326 (5'-(2-fluoro[3,4,5(-3)H3]phenyl)-spiro[1-azabicyclo [2.2.2]octane-3,2'(3'H)-furo[2,3-b]pyridine) is a potent partial agonist at the human alpha7 neuronal nicotinic receptor with sub-nanomolar affinity for the human and rat alpha7 [(125)I]
Autor:
William J. S. Lockley, J. Richard Heys
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 53:635-644
An overview is given of this Special Issue of the Journal of Labelled Compounds and Radiopharmaceuticals dealing with the subject of metal-catalysed hydrogen isotope exchange labelling. In addition to summarizing the areas covered by the contributed
Autor:
J. Richard Heys
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 53:716-721
Nickel metal in various forms is useful for the catalytic exchange labeling of a wide range of compounds from isotopic water or isotopic hydrogen gas sources. Substantial investigative work has been done on the metal's activities in simple test compo
Autor:
J. Richard Heys, Charles S. Elmore
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 52:189-200
Reports in the literature appear to differ on the effects of some C3 substituents on the relative efficiencies of isotope exchange in the nonidentical C2- and C6-positions catalyzed by organoiridium complexes. Controlled experiments were conducted us
Autor:
J. Richard Heys, Donna L. Maier, Mark E. Powell, Charles S. Elmore, Cindy Sobotka-Briner, Min Ding, Qiaoling Jiang, M. Edward Pierson, Geraldine Hill, Ladislav Mrzljak
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 330:342-351
Radiotracers suitable for positron emission tomography studies often serve as preclinical tools for in vivo receptor occupancy. The serotonin 1B receptor (5-HT(1B)) subtype is a pharmacological target used to discover treatments for various psychiatr
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 51:343-346
In support of a program to develop a treatment for depression, three isotopically labeled forms of the 5-HT1B antagonist AZ12320927 were synthesized. A tritium labeled version was synthesized for autoradiography using Ir-catalyzed hydrogen–tritium
Autor:
J. Richard Heys
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 50:770-778
An account of the development of organoiridium-catalyzed hydrogen isotope exchange methods is given for the regioselective labeling of compounds from isotopic hydrogen gas, and their current status. The concept arose out of organometallic chemistry s