Zobrazeno 1 - 10
of 106
pro vyhledávání: '"Richard Heath"'
Autor:
Rhianna J. Rowland, Richard Heath, Daniel Maskell, Rebecca F. Thompson, Neil A. Ranson, James N. Blaza, Jane A. Endicott, Martin E. M. Noble, Marco Salamina
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract p27KIP1 (cyclin-dependent kinase inhibitor 1B, p27) is a member of the CIP/KIP family of CDK (cyclin dependent kinase) regulators that inhibit cell cycle CDKs. p27 phosphorylation by CDK1/2, signals its recruitment to the SCFSKP2 (S-phase ki
Externí odkaz:
https://doaj.org/article/255a782ee4174ccbb388f8fffc48d107
Autor:
Rachael M. Cardinal, PharmD, Frank D’Amico, PhD, Elizabeth Cassidy, PharmD, Richard Heath, MD, Megan Baumgartner, PharmD
Publikováno v:
Journal of Opioid Management. 19:157-164
Objective: The opioid epidemic continues to take over 50,000 lives annually. At least 75 percent of patients present to an emergency department (ED) for pain. The objective of this study is to describe the characteristic(s) for receiving opioid, nono
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::691f85723623ae69c087c94bb56858f7
https://doi.org/10.5055/jom.2023.0770
https://doi.org/10.5055/jom.2023.0770
Autor:
Jamie A. Jarusiewicz, Satoshi Yoshimura, Anand Mayasundari, Marisa Actis, Anup Aggarwal, Kevin McGowan, Lei Yang, Yong Li, Xiang Fu, Vibhor Mishra, Richard Heath, Shilpa Narina, Shondra M. Pruett-Miller, Gisele Nishiguchi, Jun J. Yang, Zoran Rankovic
Publikováno v:
ACS Medicinal Chemistry Letters. 14:141-145
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17e763d52cb06a3a95f14566fa22a1c0
https://doi.org/10.1021/acsmedchemlett.2c00436
https://doi.org/10.1021/acsmedchemlett.2c00436
Autor:
Gemma Davison, Mathew P. Martin, Shannon Turberville, Selma Dormen, Richard Heath, Amy B. Heptinstall, Marie Lawson, Duncan C. Miller, Yi Min Ng, James N. Sanderson, Ian Hope, Daniel J. Wood, Céline Cano, Jane A. Endicott, Ian R. Hardcastle, Martin E. M. Noble, Michael J. Waring
Publikováno v:
Journal of Medicinal Chemistry. 65:15416-15432
The development of ligands for biological targets is critically dependent on the identification of sites on proteins that bind molecules with high affinity. A set of compounds, called FragLites, can identify such sites, along with the interactions re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4f5f45f4a2b13dc353a06e52583b772
https://doi.org/10.1021/acs.jmedchem.2c01357
https://doi.org/10.1021/acs.jmedchem.2c01357
Autor:
Alexandria Taylor, Isabelle Zerfas, Christina Le, Frank D'Amico, F. Richard Heath, Megan Baumgartner
Publikováno v:
The Journal of Emergency Medicine. 63:10-16
Antibiotics are not recommended in healthy, uncomplicated adults for the treatment of acute bronchitis, yet are still often prescribed. No randomized studies have examined whether prescribing antibiotics in the emergency department (ED) impacts hospi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3743751383f065f1b5c5ab2b89436e1e
https://doi.org/10.1016/j.jemermed.2022.01.020
https://doi.org/10.1016/j.jemermed.2022.01.020
Autor:
Jun J. Yang, William L. Carroll, Aleš Hnízda, Richard Heath, Youming Shao, Wentao Yang, Xujie Zhao, Julia Meyer, Jing Li, Shuguang Liu, Takaya Moriyama
Relapse remains a formidable challenge for acute lymphoblastic leukemia (ALL). Recently, recurrent mutations in NT5C2 were identified as a common genomic lesion unique in relapsed ALL and were linked to acquired thiopurine resistance. However, molecu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5272bb7bd6c0f8e06d3c7f4adbd03654
https://doi.org/10.1158/1535-7163.c.6539578.v1
https://doi.org/10.1158/1535-7163.c.6539578.v1
Autor:
Luke Gaughan, Dominic Jones, Craig Robson, Laura Walker, Richard Heath, Sirintra Nakjang, Matthew Simcock, Lewis Chaytor
siRNA sequences
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a97833f5766beb5120226ff73538ae67
https://doi.org/10.1158/1541-7786.22512760
https://doi.org/10.1158/1541-7786.22512760
Autor:
Jun J. Yang, William L. Carroll, Aleš Hnízda, Richard Heath, Youming Shao, Wentao Yang, Xujie Zhao, Julia Meyer, Jing Li, Shuguang Liu, Takaya Moriyama
This supplementary table describes metabolite levels and statistics from metabolite experiments
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73bb0be911b08c403bcd72aa467b961a
https://doi.org/10.1158/1535-7163.22510330.v1
https://doi.org/10.1158/1535-7163.22510330.v1
Autor:
Luke Gaughan, Dominic Jones, Craig Robson, Laura Walker, Richard Heath, Sirintra Nakjang, Matthew Simcock, Lewis Chaytor
qPCR primers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::692786eda2342b4423fcd10538c1b335
https://doi.org/10.1158/1541-7786.22512757.v1
https://doi.org/10.1158/1541-7786.22512757.v1
Autor:
Luke Gaughan, Dominic Jones, Craig Robson, Laura Walker, Richard Heath, Sirintra Nakjang, Matthew Simcock, Lewis Chaytor
The androgen receptor (AR) is a key driver of prostate cancer development. Antiandrogens effectively inactivate the AR, but subsequent AR reactivation progresses the disease to castrate-resistant prostate cancer (CRPC). Constitutively active AR splic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fb54d1d62d6dd53bf177c5e522059e9
https://doi.org/10.1158/1541-7786.c.6540328.v1
https://doi.org/10.1158/1541-7786.c.6540328.v1