Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Richard Haworth"'
Autor:
Graham Paul, Stuart W. Naylor, Nicholas P. Macri, Scott Manetz, Richard Haworth, A. Peter Hall, David Jones, Thierry Flandre, Jeffrey S. Tepper, Michela Gregori, Annick Cauvin, Molly H. Boyle, Sydney Mukaratirwa, Alison Wolfreys, Renaud Fleurance, Inge Tarnow, Kristen J. Nikula, Alessandro Piaia, Mark Price, Ian Robinson, Andrew Allen, Tom Gelzleichter, Mark C Freke, Karyn Colman, Andreas M Hohlbaum, Maurice G Cary
Publikováno v:
Toxicologic Pathology. 49:235-260
The inhalation route is a relatively novel drug delivery route for biotherapeutics and, as a result, there is a paucity of published data and experience within the toxicology/pathology community. In recent years, findings arising in toxicology studie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::507bdc0e870c9ffe85569d58c5326be1
https://doi.org/10.1177/0192623320976094
https://doi.org/10.1177/0192623320976094
Autor:
Molly H. Boyle, Richard Haworth, George Karantabias, Reenu Gupta, Paul Edwards, Rajni Fagg, Mark Price
Publikováno v:
Toxicologic Pathology. 49:296-314
The safety of 2 single domain antibodies (dAbs) was evaluated by inhalation toxicology studies in the cynomolgus monkey. In the first case study, a 14-day repeat-dose study evaluating an anti-thymic stromal lymphopoietin (anti-TSLP) dAb resulted in m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cf88016b79c59c33d3e27bd3818683c
https://doi.org/10.1177/0192623320972387
https://doi.org/10.1177/0192623320972387
Publikováno v:
Toxicology Research
Toxicity studies using mammalian species are generally required to provide safety data to support clinical development and licencing registration for potential new pharmaceuticals. International regulatory guidelines outline recommendations for the o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8b9b7ff56dd586ef198f802d104099f
https://doi.org/10.1093/toxres/tfaa081
https://doi.org/10.1093/toxres/tfaa081
Autor:
Richard Haworth, Michaela Sharpe
Publikováno v:
Toxicologic Pathology. 49:1308-1316
In 2011, Goldring and colleagues published a review article describing the potential safety issues of novel stem cell-derived treatments. Immunogenicity and immunotoxicity of the administered cell product were considered risks in the light of clinica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e44ea5129388e6e93e6e33a892692f2
https://doi.org/10.1177/0192623320918241
https://doi.org/10.1177/0192623320918241
Autor:
Adrian C. Wright, Charlie R. Scales, Roger N. Sinclair, Paul A. Bingham, Natalia M. Vedishcheva, Susan D. Forder, Joanna L. Shaw, Gabriel J. Cuello, Diane Holland, Richard Haworth
Publikováno v:
Physics and Chemistry of Glasses: European Journal of Glass Science and Technology Part B. 58:78-91
The neutron diffraction isotopic substitution technique is employed to investigate the environment of Fe3+/Fe2+ cations in a sodium borosilicate glass matrix of composition 0.210Na2O0.18511B2O30.605SiO2. The neutron diffraction data were obtain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b66d83fe4d684f930ad05603be5cc85
https://doi.org/10.13036/17533562.58.3.016
https://doi.org/10.13036/17533562.58.3.016
Publikováno v:
Toxicologic pathology. 47(2)
GlaxoSmithKline has recently made significant organizational changes to its nonclinical safety, drug metabolism and pharmacokinetic, and laboratory animal science/veterinary functions, with the goal to increase our focus on scientific partnership wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49f14ed6c801f7552205f78f105e8795
https://pubmed.ncbi.nlm.nih.gov/30651043
https://pubmed.ncbi.nlm.nih.gov/30651043
Autor:
Richard Haworth, Michaela Sharpe
Publikováno v:
Regenerative Medicine. 10:231-234
Cautious approaches in the clinic are currently proposed, supported by relevant in vitro, in vivo and published data. Key to developing our understanding of the risks of immune rejection of stem cell based therapies will be the inclusion of immunolog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36a49b697c6c683ba2e6a7f37044aeb6
https://doi.org/10.2217/rme.14.50
https://doi.org/10.2217/rme.14.50
Autor:
Richard Haworth, Michael Mirsky, Gerald G. Long, Justin D. Vidal, Ute Bach, Anke Heuser, Ronald A. Herbert, Karen Regan, Midori Yoshida, F. Russell Westwood, Johannes H. Harleman, George L. Foley, Darlene Dixon, Eric Van Esch, Roger Alison, Karyn Colman
Publikováno v:
Journal of Toxicologic Pathology
The INHAND (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice) Project (www.toxpath.org/inhand.asp) is a joint initiative of the Societies of Toxicological Pathology from Europe (ESTP), Great Britain (BS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14316589e64325c4d1fddaf85284ec7f
http://europepmc.org/articles/PMC4253081
http://europepmc.org/articles/PMC4253081
Autor:
Justyna Korczynska, Lemy Tsikna, Zoe Hughes-Thomas, Richard Haworth, Christopher J. Roberts, John Warrack, Steven D. Sorden, Irene Papanicolaou, Rodd Polsky, Eric Dobrzynski, Edit Kurali, Timothy Streit, Thomas Wilde, Jeffery J Prusakiewicz, Brian J Christian, Peter C. Adamson, T Michael Nork, Ian Richard Catchpole, Craig Struble, Caroline Sychterz, James Walford, Chi-Man Tang, Daniel Gibson, Ruud Verrijk, Paul E. Miller, Fiona Cook, Jos Smal
Publikováno v:
Journal of controlled release : official journal of the Controlled Release Society
A potent anti-vascular endothelial growth factor (VEGF) biologic and a compatible delivery system were co-evaluated for protection against wet age-related macular degeneration (AMD) over a 6month period following a single intravitreal (IVT) injection
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f9ca6065ba82c3a95211a3152eff24c
https://pubmed.ncbi.nlm.nih.gov/27810558
https://pubmed.ncbi.nlm.nih.gov/27810558
Autor:
Adrian C. Wright, J. Ross Stewart, Bruce G. Aitken, Roger N. Sinclair, Richard Haworth, Jon W. Taylor, Gabriel J. Cuello
Publikováno v:
Journal of Non-Crystalline Solids. 357:2502-2510
A neutron diffraction investigation has been performed of the structure of four chalcogenide glasses, using the D4c diffractometer on the high-flux reactor at the Institut Laue-Langevin (ILL). Vitreous Ge 3 As 52 S 45 is shown to have a structure bas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::49e18acedee17ab99d219d0469e50e6c
https://doi.org/10.1016/j.jnoncrysol.2010.12.054
https://doi.org/10.1016/j.jnoncrysol.2010.12.054