Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Richard Harkewicz"'
Autor:
Christian R.H. Raetz, Teresa A. Garrett, C. Michael Reynolds, Walter A. Shaw, Jeff D. Moore, Dale C. Smith, Jr., Anthony A. Ribeiro, Robert C. Murphy, Richard J. Ulevitch, Colleen Fearns, Donna Reichart, Christopher K. Glass, Chris Benner, Shankar Subramaniam, Richard Harkewicz, Rebecca C. Bowers-Gentry, Matthew W. Buczynski, Jennifer A. Cooper, Raymond A. Deems, Edward A. Dennis
Publikováno v:
Journal of Lipid Research, Vol 47, Iss 5, Pp 1097-1111 (2006)
The LIPID MAPS Consortium (www.lipidmaps.org) is developing comprehensive procedures for identifying all lipids of the macrophage, following activation by endotoxin. The goal is to quantify temporal and spatial changes in lipids that occur with cellu
Externí odkaz:
https://doaj.org/article/2d280c3e171c460cbc4494ca45c0652a
Autor:
Agnès Boullier, Peter Friedman, Richard Harkewicz, Karsten Hartvigsen, Simone R. Green, Felicidad Almazan, Edward A. Dennis, Daniel Steinberg, Joseph L. Witztum, Oswald Quehenberger
Publikováno v:
Journal of Lipid Research, Vol 46, Iss 5, Pp 969-976 (2005)
We have previously shown that CD36 recognizes oxidation products of phospholipids on oxidized LDL (OxLDL) such as 1-palmitoyl-2-(5′-oxovaleroyl)-sn-glycero-3-phosphocholine (POVPC). The current study was designed to examine whether the phosphocholi
Externí odkaz:
https://doaj.org/article/ef4940dea5a8438fb60c7c66ab39a3d0
Publikováno v:
Biochimica et biophysica acta, vol 1811, iss 11
Fatty acid-derived eicosanoids and N-acylethanolamines (NAE) are important bioactive lipid mediators involved in numerous biological processes including cell signaling and disease progression. To facilitate research on these lipid mediators, we have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2980a703ee9dc0dfae934c4049a3dacf
https://doi.org/10.1016/j.bbalip.2011.06.005
https://doi.org/10.1016/j.bbalip.2011.06.005
Autor:
Edward A. Dennis, Richard Harkewicz
Publikováno v:
Annual review of biochemistry, vol 80, iss 1
Lipidomics, a major part of metabolomics, constitutes the detailed analysis and global characterization, both spatial and temporal, of the structure and function of lipids (the lipidome) within a living system. As with proteomics, mass spectrometry h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f7067eeb788f9c2e912d1a1a6f42526
https://doi.org/10.1146/annurev-biochem-060409-092612
https://doi.org/10.1146/annurev-biochem-060409-092612
Autor:
Elaine Wang, Robert C. Murphy, Shankar Subramaniam, Alfred H. Merrill, Shakti Gupta, Eoin Fahy, Ziqiang Guan, Walter A. Shaw, Bonne M. Thompson, Gary Hardiman, Christopher K. Glass, Manish Sud, Andrea C. Ryan, Edward A. Dennis, H. Alex Brown, Jeffrey G. McDonald, Raymond A. Deems, Yihua Zhao, David W. Russell, M. Cameron Sullards, Mano Ram Maurya, Donna Reichart, Stephen B. Milne, Oswald Quehenberger, Richard Harkewicz, Christian R. H. Raetz, Teresa A. Garrett, David S. Myers
Publikováno v:
The Journal of biological chemistry, vol 285, iss 51
We report the lipidomic response of the murine macrophage RAW cell line to Kdo(2)-lipid A, the active component of an inflammatory lipopolysaccharide functioning as a selective TLR4 agonist and compactin, a statin inhibitor of cholesterol biosynthesi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06b225e3daf7f1b5d0a7259274dc5c18
https://doi.org/10.1074/jbc.m110.182915
https://doi.org/10.1074/jbc.m110.182915
Autor:
Jennifer Pattison, Felicidad Almazan, Karsten Hartvigsen, Philipp Wiesner, Yury I. Miller, Edward A. Dennis, Tiffany Sayaphupha, Elena Deer, Sotirios Tsimikas, Longhou Fang, Richard Harkewicz, Soo-Ho Choi, Joseph L. Witztum
Publikováno v:
Journal of Biological Chemistry. 285:32343-32351
A novel hypercholesterolemic zebrafish model has been developed to study early events of atherogenesis. This model utilizes optically transparent zebrafish larvae, fed a high cholesterol diet (HCD), to monitor processes of vascular inflammation in li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b9c4ddf568c1b03e6626f34f9cf98dd5
https://doi.org/10.1074/jbc.m110.137257
https://doi.org/10.1074/jbc.m110.137257
Autor:
Joseph L. Witztum, Edward A. Dennis, Felicidad Almazan, Karsten Hartvigsen, Yury I. Miller, Richard Harkewicz
Publikováno v:
The Journal of biological chemistry, vol 283, iss 16
Oxidation of low density lipoprotein (LDL) occurs in vivo and significantly contributes to the development of atherosclerosis. An important mechanism of LDL oxidation in vivo is its modification with 12/15-lipoxygenase (LO). We have developed a model
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83f7f72e1859945fda8f43ba69bb9631
https://doi.org/10.1074/jbc.m709006200
https://doi.org/10.1074/jbc.m709006200
Publikováno v:
The Journal of biological chemistry, vol 282, iss 5
Eicosanoids, including the prostaglandins, leukotrienes, hydroxyeicosatetraenoic acids, epoxyeicosatetraenoic acids, and related compounds, are biosynthetic, bioactive mediators derived from arachidonic acid (AA), a 20:4(n-6) fatty acid. We have deve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::297e00f3ce92f0aad532a5af7356772c
https://doi.org/10.1074/jbc.m610067200
https://doi.org/10.1074/jbc.m610067200
Autor:
Klaus Bukhave, Gunhild Hølmer, Karsten Hartvigsen, Arnis Kuksis, Amir Ravandi, Hiroshi Kamido, Richard Harkewicz
Publikováno v:
Lipids. 41:679-693
This study examines the feasibility that peroxidation and lipolysis of 1-O-alkyl-2,3-diacyl-sn-glycerols (DAGE) found in shark liver oil and human milk fat constitutes a potential source of dietary precursors of platelet activating factor (PAF) mimic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f613a3088506eaaf03357af8e48dc45
https://doi.org/10.1007/s11745-006-5019-4
https://doi.org/10.1007/s11745-006-5019-4
Autor:
Lingjun Li, Richard Harkewicz, Richard D. Smith, Gordon A. Anderson, Christophe Masselon, Ljiljana Paša-Tolić, Sang Won Lee
Publikováno v:
PROTEOMICS. 3:1279-1286
Multiplexed tandem mass spectrometry (MS/MS) has recently been demonstrated as a means to increase the throughput of peptide identification in liquid chromatography (LC) MS/MS experiments. In this approach, a set of parent species is dissociated simu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c83902bbf40ec3fee0d8dbf98944d5ed
https://doi.org/10.1002/pmic.200300448
https://doi.org/10.1002/pmic.200300448