Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Richard Harbottle"'
Autor:
Dirk Jäger, Aileen Berger, Alexandra Tuch, Claudia Luckner‐Minden, Rosa Eurich, Mario Hlevnjak, Andreas Schneeweiss, Peter Lichter, Sebastian Aulmann, Claus‐Peter Heussel, Carlo Fremd, Richard Harbottle, Inka Zörnig, Patrick Schmidt
Publikováno v:
Clinical and Translational Medicine, Vol 14, Iss 7, Pp n/a-n/a (2024)
Externí odkaz:
https://doaj.org/article/d760168d1320416e85cdc19cb58e2a0d
Autor:
Tatjana Chan, Hiu Man Grisch-Chan, Philipp Schmierer, Ulrike Subotic, Nicole Rimann, Tanja Scherer, Udo Hetzel, Matthias Bozza, Richard Harbottle, James A. Williams, Barbara Steblaj, Simone K. Ringer, Johannes Häberle, Xaver Sidler, Beat Thöny
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 24, Iss , Pp 268-279 (2022)
Hepatic gene therapy by delivering non-integrating therapeutic vectors in newborns remains challenging due to the risk of dilution and loss of efficacy in the growing liver. Previously we reported on hepatocyte transfection in piglets by intraportal
Externí odkaz:
https://doaj.org/article/9af6b8771dc44a3caf3414a328b73cff
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 20, p 15225 (2023)
Choroideremia (CHM) is an X-linked chorioretinal dystrophy leading to progressive retinal degeneration that results in blindness by late adulthood. It is caused by mutations in the CHM gene encoding the Rab Escort Protein 1 (REP1), which plays a cruc
Externí odkaz:
https://doaj.org/article/2183782facfc484d9a8be6e602ce9bd2
Autor:
Daniele Viarisio, Karin Müller-Decker, Rosita Accardi, Alexis Robitaille, Matthias Dürst, Katrin Beer, Lars Jansen, Christa Flechtenmacher, Matthias Bozza, Richard Harbottle, Catherine Voegele, Maude Ardin, Jiri Zavadil, Sandra Caldeira, Lutz Gissmann, Massimo Tommasino
Publikováno v:
PLoS Pathogens, Vol 14, Iss 1, p e1006783 (2018)
Cutaneous beta human papillomavirus (HPV) types are suspected to be involved, together with ultraviolet (UV) radiation, in the development of non-melanoma skin cancer (NMSC). Studies in in vitro and in vivo experimental models have highlighted the tr
Externí odkaz:
https://doaj.org/article/7fa4403cea6f40ffa5dbfb8e53cb8dce
Publikováno v:
BioTechniques, Vol 35, Iss 2, Pp 317-324 (2003)
Gene therapy clinical trials have highlighted the importance of specific cellular/tissue targeting of gene delivery vectors. Phage display libraries are powerful tools for the selection of novel peptide ligands as targeting moieties because of their
Externí odkaz:
https://doaj.org/article/ecd64eb6dc354698b7345413a8d52700
Autor:
Tsunaki Hongu, Maren Pein, Jacob Insua-Rodríguez, Ewgenija Gutjahr, Greta Mattavelli, Jasmin Meier, Kristin Decker, Arnaud Descot, Matthias Bozza, Richard Harbottle, Andreas Trumpp, Hans-Peter Sinn, Angela Riedel, Thordur Oskarsson
Publikováno v:
Nature Cancer. 3:486-504
Disseminated cancer cells frequently lodge near vasculature in secondary organs. However, our understanding of the cellular crosstalk invoked at perivascular sites is still rudimentary. Here, we identify intercellular machinery governing formation of
Autor:
Matthias Bozza, Richard Harbottle
Publikováno v:
Cell and Gene Therapy Insights. 7:1487-1493
Autor:
Eren Boga, Luisa Berger, Alice De Roia, Inka Zörnig, Robert Embacher, Stefan B. Eichmüller, Dirk Jäger, Richard Harbottle, Patrick Schmidt
Publikováno v:
Cancer Research. 83:1769-1769
Within the last decade CAR-T cells have changed the landscape of treatment regimen for leukemia and myeloma, which is reflected by the first FDA approval of this class of living drugs in 2017. As of today, the clinical trial situation aims on CAR-T a
Autor:
Dirk Jäger, Inka Zörnig, Aileen Berger, Patrick Schmidt, Richard Harbottle, Alexandra Tuch, Matthias Bozza, Andreas Schmidt, Alice De Roia, Margareta P. Correia
Publikováno v:
Science Advances
Autosomally replicating episomal DNA nanovectors allow clinical-scale CAR-T cell manufacturing.
The compelling need to provide adoptive cell therapy (ACT) to an increasing number of oncology patients within a meaningful therapeutic window makes
The compelling need to provide adoptive cell therapy (ACT) to an increasing number of oncology patients within a meaningful therapeutic window makes
Autor:
Williams James A, Martin R. Sprick, Alice De Roia, Vanessa Vogel, Richard Harbottle, Rienk Offringa, Edward W. Green, Corinna Klein, Matthias Bozza, Elisa Espinet
Publikováno v:
Molecular Therapy. Methods & Clinical Development
Molecular Therapy: Methods & Clinical Development, Vol 17, Iss, Pp 957-968 (2020)
Molecular Therapy: Methods & Clinical Development, Vol 17, Iss, Pp 957-968 (2020)
We describe herein non-integrating minimally sized nano-S/MAR DNA vectors, which can be used to genetically modify dividing cells in place of integrating vectors. They represent a unique genetic tool, which avoids vector-mediated damage. Previous wor