Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Richard Hallworth"'
Autor:
Nermien Waly, Richard Hallworth
Publikováno v:
Journal of Circadian Rhythms, Vol 13 (2015)
The suprachiasmatic nucleus (SCN) is the circadian pacemaker. The pineal hormone melatonin is involved in the regulation of circadian phase. As a part of the circadian system its synthesis and secretion is under SCN control. On the other hand, melato
Externí odkaz:
https://doaj.org/article/91ebd77eccb74e2dbf32a97a551bb257
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e38471 (2012)
Aminoglycosides (AG), including gentamicin (GM), are the most frequently used antibiotics in the world and are proposed to cause irreversible cochlear damage and hearing loss (HL) in 1/4 of the patients receiving these life-saving drugs. Akin to the
Externí odkaz:
https://doaj.org/article/3ec26f0df2924db5bed7b1bd5f13010c
Autor:
Richard Hallworth
Publikováno v:
AIP Conference Proceedings.
Clear evidence now points to mammalian prestin being a tetramer. Tetramerization is found to be ubiquitous in the Slc26a family, of which mammalian prestin is a member. However, no functional role for oligomerization has yet been found. I here show e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed943a77ecd44d7bebfb82cb8f37676f
https://doi.org/10.1063/1.5038500
https://doi.org/10.1063/1.5038500
Publikováno v:
Journal of Eukaryotic Microbiology. 62:144-148
When Paramecium encounters positive stimuli, the membrane hyperpolarizes and ciliary beat frequency increases. We adapted an established immobilization protocol using a biological adhesive and a novel digital analysis system to quantify beat frequenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9371a2bf785f3bd416bd0e2e15dfb769
https://doi.org/10.1111/jeu.12153
https://doi.org/10.1111/jeu.12153
Autor:
Michael G, Nichols, Richard, Hallworth
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1427
The advent of techniques for imaging solitary fluorescent molecules has made possible many new kinds of biological experiments. Here, we describe the application of single-molecule imaging to the problem of subunit stoichiometry in membrane proteins.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a81ea5d10fa343b928fb0424735cb5f3
https://pubmed.ncbi.nlm.nih.gov/27259928
https://pubmed.ncbi.nlm.nih.gov/27259928
Autor:
Richard Hallworth, Michael G. Nichols
Publikováno v:
Methods in Molecular Biology ISBN: 9781493936137
The advent of techniques for imaging solitary fluorescent molecules has made possible many new kinds of biological experiments. Here, we describe the application of single-molecule imaging to the problem of subunit stoichiometry in membrane proteins.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::877b281be1af52d87f72aebf729ab726
https://doi.org/10.1007/978-1-4939-3615-1_11
https://doi.org/10.1007/978-1-4939-3615-1_11
Autor:
Clifford Hecht, Michael G. Nichols, Jorge Vergen, Lyandysha V. Zholudeva, Richard Hallworth, Meg M. Marquardt
Publikováno v:
Microscopy and Microanalysis. 18:761-770
Metabolism and mitochondrial dysfunction are known to be involved in many different disease states. We have employed two-photon fluorescence imaging of intrinsic mitochondrial reduced nicotinamide adenine dinucleotide (NADH) to quantify the metabolic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68cf70cfc2bdd9a572541d90107e6f81
https://doi.org/10.1017/s1431927612000529
https://doi.org/10.1017/s1431927612000529
Autor:
Michael G. Nichols, Richard Hallworth
Publikováno v:
Journal of Neurophysiology. 107:5-11
The unusual membrane motor protein prestin is essential for mammalian hearing and for the survival of cochlear outer hair cells. While prestin has been demonstrated to be a homooligomer, by Western blot and FRET analyses, the stoichiometry of self as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::140d04247d2ead6a11dff6f7bf370449
https://doi.org/10.1152/jn.00728.2011
https://doi.org/10.1152/jn.00728.2011
Publikováno v:
Journal of Neurophysiology. 106:2358-2367
The creation of several prestin knockout and knockin mouse lines has demonstrated the importance of the intrinsic outer hair cell membrane protein prestin to mammalian hearing. However, the structure of prestin remains largely unknown, with even its
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3865505f43c72aa13573d67331e5ed77
https://doi.org/10.1152/jn.00496.2011
https://doi.org/10.1152/jn.00496.2011
Publikováno v:
Brain Research. 1277:37-41
Hair cell loss is a major cause of sensorineural hearing loss. We have developed a method to examine metabolic events in hair cells in response to stimuli known to cause hair cell loss, such as acoustic trauma and aminoglycoside administration. The m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08f74337e085025997cbb7ac8c1e9f4f
https://doi.org/10.1016/j.brainres.2009.02.052
https://doi.org/10.1016/j.brainres.2009.02.052