Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Richard H. Weisbart"'
Publikováno v:
The Scientific World Journal, Vol 5, Pp 782-788 (2005)
Protein therapy refers to the direct delivery of therapeutic proteins to cells and tissues with the goal of ameliorating or modifying a disease process. Current techniques for delivering proteins across cell membranes include taking advantage of rece
Externí odkaz:
https://doaj.org/article/8ffdeba24aa7451888f908d12e4ae891
Autor:
Chris Hino, Grace Chan, Gwen Jordaan, Sophia S. Chang, Jacquelyn T. Saunders, Mohammad T. Bashir, James E. Hansen, Joseph Gera, Richard H. Weisbart, Robert N. Nishimura
Publikováno v:
Cell Stress and Chaperones.
Heat shock proteins (HSPs), especially Hsp70 (HSPA1), have been associated with cellular protection from various cellular stresses including heat, hypoxia-ischemia, neurodegeneration, toxins, and trauma. Endogenous HSPs are often synthesized in direc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a5088e42a4fd95c0d30dfd168cdfab94
https://doi.org/10.1007/s12192-023-01349-6
https://doi.org/10.1007/s12192-023-01349-6
Autor:
Chris Hino, Grace Chan, Gwen Jordaan, Sophia S Chang, Jacquelyn T Saunders, Mohammad T Bashir, James E Hansen, Joseph Gera, Richard H Weisbart, Robert N Nishimura
Heat shock proteins (HSPs), especially Hsp70 (HSPA1), have been associated with cellular protection from various cellular stresses including heat, hypoxia-ischemia, neurodegeneration, toxins, and trauma. Endogenous HSPs are often synthesized in direc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91a5f5c4abf1e10850f4f5e179a746a8
https://doi.org/10.1101/2023.02.22.529417
https://doi.org/10.1101/2023.02.22.529417
Autor:
Robert P. Casillas, Missag H. Parseghian, Richard H. Weisbart, Stephen T Hobson, Glenn T. Reynolds, Rick Tuttle, Richard A. Richieri, Robert N. Nishimura
Publikováno v:
Toxicol Mech Methods
Phosgene is classified as a chemical warfare agent, yet data on its short-duration high concentration toxicity in a nose-only exposure rat model is sparse and inconsistent. Hence, an exposure system for short term/high concentration exposure was deve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d56fc3d549e62006995e59cb6331362
https://pubmed.ncbi.nlm.nih.gov/31237465
https://pubmed.ncbi.nlm.nih.gov/31237465
Publikováno v:
International Journal of Cancer. 138:182-186
TP53 is a tumor suppressor gene that is mutated in 50% of cancers, and its function is tightly regulated by the E3 ligase, Mdm2. Both p53 and Mdm2 are localized in the cell nucleus, a site that is impervious to therapeutic regulation by most antibodi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::51589ac52f51c263ea76c2aed0bc5d1c
https://doi.org/10.1002/ijc.29685
https://doi.org/10.1002/ijc.29685
Autor:
Maria N. Garnovskaya, Mary G. Blanton, Richard H. Weisbart, Nancy L. Goicochea, Michael B. Lilly, Grace Chan
Publikováno v:
Protein engineering, designselection : PEDS. 30(12)
Castration-resistant prostate cancer cells exhibit continued androgen receptor signaling in spite of low levels of ligand. Current therapies to block androgen receptor signaling act by inhibiting ligand production or binding. We developed bispecific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58d4d1cc819ccc3566f6a929e54dc234
https://pubmed.ncbi.nlm.nih.gov/29228299
https://pubmed.ncbi.nlm.nih.gov/29228299
Autor:
Robert N. Nishimura, Hideki Kawai, Takehiro Nakahara, Takashi Tanimoto, Richard A. Richieri, H. William Strauss, Francis G. Blankenberg, John Billimek, Richard H. Weisbart, Dongbin Kim, Jagat Narula, Grace Chan, Partho P. Sengupta, Glenn T. Reynolds, Artiom Petrov, Missag H. Parseghian, Takashi Akasaka, Farhan Chaudhry, Navneet Narula, Neena B. Haider
Publikováno v:
Journal of the American College of Cardiology. 70(12)
Background Although early reperfusion is the most desirable intervention after ischemic myocardial insult, it may add to damage through oxidative stress. Objectives This study investigated the cardioprotective effects of a single intravenous dose of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec029b3a6d99cbe94d08212f19c55f10
https://pubmed.ncbi.nlm.nih.gov/28911513
https://pubmed.ncbi.nlm.nih.gov/28911513
Autor:
Joseph Gera, Cheri Cloninger, Arnold J Levine, Richard H. Weisbart, Grace Chan, Robert N. Nishimura, James E. Hansen, Erica Li
Publikováno v:
Molecular Cancer Therapeutics. 11:2169-2173
The therapeutic use of antibodies is restricted by the limited access of antibodies to intracellular compartments. To overcome this limitation, we developed a cell-penetrating monoclonal antibody, mAb 3E10, as an intracellular delivery vehicle for th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03e215cd927fbade8906cd392079b531
https://doi.org/10.1158/1535-7163.mct-12-0476-t
https://doi.org/10.1158/1535-7163.mct-12-0476-t
Autor:
Emil R. Heinze, Sue Y. Chung, Rachel Mory, Raz Khavari, Asif Alavi, Grace Chan, Robert N. Nishimura, Richard H. Weisbart
Publikováno v:
Oncology Letters. 2:665-668
Foxp3 is a nuclear transcription factor that is both a tumor suppressor factor and regulator of T-regulatory cell (Treg) function, and is a potential therapeutic target in both autoimmunity and cancer. In order to distinguish molecular pathways respo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::370a886bf530c654e936c75d50ada4af
https://doi.org/10.3892/ol.2011.307
https://doi.org/10.3892/ol.2011.307
Autor:
Isaac H. Liao, Frank R. Sharp, Xinhua Zhan, Robert N. Nishimura, Bradley P. Ander, James E. Hansen, Chester Kim, Douglas Clements, Richard H. Weisbart
Publikováno v:
Stroke. 41:538-543
Background and Purpose— This study investigated the effects of intravenous recombinant Fv-Hsp70 protein on infarction volume and behavior after experimental ischemic stroke. Methods— Focal cerebral ischemia was produced by occluding the middle ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e61bc328c68ad752367cf385964671f
https://doi.org/10.1161/strokeaha.109.572537
https://doi.org/10.1161/strokeaha.109.572537