Výsledky vyhledávání - "Richard H. Spector"

A new thymine free synthesis of the anti-AIDS drug d4T via regio/stereo controlled β-elimination of bromoacetates

Autor: Sandra L. Quinlan, Richard H. Spector, Bang-Chi Chen, J. Gregory Reid

Publikováno v: Tetrahedron Letters. 39:729-732

The anti-AIDS drug d4T was prepared without contamination of the nucleoside bond cleaved by-product thymine from the readily available ribonucleoside 5-methyluridine (1). This was accomplished by using a new strategy which involved a regio/stereo con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2a07811600e471d7135d4ea7281746f1
https://doi.org/10.1016/s0040-4039(97)01084-8

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5′-Benzoyl-2′α-bromo-3′-O-methanesulfonylthymidine: A superior nucleoside for the synthesis of the anti-AIDS drug D4T (Stavudine)

Autor: Jacqueline G. George, Derron R. Stark, Saibaba Racha, Bang-Chi Chen, Steve P. Brundidge, J. Gregory Reid, Sandra L. Quinlan, Vicki H. Audia, Emerich Eisenreich, Richard H. Spector

Publikováno v: Tetrahedron Letters. 36:7957-7960

Summary The anti-AIDS drug d4T is prepared in 75% overall yield starting from the readily available ribonucleoside 5-methyluridine (1). The key step in this new synthesis is the zinc-induced reductive elimination of the bromomesylate 4, which affords

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5eb11457ab5880f94123200dfbab1d8c
https://doi.org/10.1016/0040-4039(95)01752-4

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Condensation reactions of activated picolines with anthranilate esters ando-nitrobenzaldehyde: Improved syntheses of the antiarrhythmic drug encainide

Autor: Richard H. Spector, Gary D. Madding, John L. Dillon, Mary E. Wire

Publikováno v: Journal of Heterocyclic Chemistry. 30:707-713

Two new and improved syntheses of the antiarrhythmic drug Encainide, 1, are presented. The first approach is based on the condensation of 2-picolyllithium with the p-anisoyl amide of methyl anthranilate, 3, followed by a series of catalytic hydrogena

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::47b48c078159256fb5ca98481e5b0281
https://doi.org/10.1002/jhet.5570300321

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ChemInform Abstract: Condensation Reactions of Activated Picolines with Anthranilate Esters and o-Nitrobenzaldehyde: Improved Syntheses of the Antiarrhythmic Drug Encainide

Autor: Mary E. Wire, Richard H. Spector, John L. Dillon, Gary D. Madding

Publikováno v: ChemInform. 24

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::de27a9c8f9da44b76cbe50791ca4c16e
https://doi.org/10.1002/chin.199349189

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ChemInform Abstract: 5′-Benzoyl-2′α-bromo-3′-O-methanesulfonylthymidine: A Superior Nucleoside for the Synthesis of the anti-AIDS Drug D4T (Stavudine)

Autor: J. G. George, B.‐C. Chen, Saibaba Racha, Sandra L. Quinlan, Derron R. Stark, E. Eisenreich, Richard H. Spector, V. H. Audia, J. G. Reid, S. P. Brundidge

Publikováno v: ChemInform. 27

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::09e059fe7eec83dc9e05d20b0789722e
https://doi.org/10.1002/chin.199608241

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ChemInform Abstract: A New Thymine Free Synthesis of the anti-AIDS Drug d4T via Regio/Stereo Controlled β-Elimination of Bromoacetates

Autor: J. G. Reid, Richard H. Spector, Sandra L. Quinlan, B.‐C. Chen

Publikováno v: ChemInform. 29

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::14ac6b8d9ac6938f7f3b67f68ca6d5f5
https://doi.org/10.1002/chin.199819238

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A Crystallization-Induced Stereoselective Glycosidation Reaction in the Synthesis of the Anticancer Drug Etoposide

Autor: John L. Dillon, Brian Harrison, Sean Kelly, David H. Vipond, Frank Gibson, Richard H. Spector, Purushotham Vemishetti, Lee J. Silverberg

Publikováno v: Organic Letters. 2:3281-3283

The anticancer drug etoposide, 1, is prepared in 79% overall yield from readily available 4'-demethyl-4-epipodophyllotoxin, 3, and 4, 6-O-ethylidene-2,3-O-dibenzyl-D-glucose, 4, via a crystallization-induced stereoselective glycosidation reaction fol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f6c9ef76730b8cefabb050208559c02
https://doi.org/10.1021/ol006262n

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ChemInform Abstract: A Crystallization-Induced Stereoselective Glycosidation Reaction in the Synthesis of the Anticancer Drug Etoposide

Autor: Purushotham Vemishetti, Sean Kelly, David H. Vipond, Lee J. Silverberg, John L. Dillon, Richard H. Spector, Frank Gibson, Brian Harrison

Publikováno v: ChemInform. 32

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f00df3588ce12fe083c0796086e35aa6
https://doi.org/10.1002/chin.200104081

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1,2,3-benzotriazines. IV. The chemical reactivity of benzimidazo[1,2-c] [1,2,3]benzotriazine

Autor: Richard H. Spector, Madeleine M. Joulliéa

Publikováno v: Journal of Heterocyclic Chemistry. 6:605-612

The reactions of benzimidazo[1,2-c][1,2,3]benzotriazine (1) with fluoroboric acid, potassium iodide and phenyl isothiocyanate are described. The structure of the phenyl isothiocyanate product is elucidated by chemical and spectroscopic techniques. Th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4f1746a663030f37599a9cfd0cb8680e
https://doi.org/10.1002/jhet.5570060502

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