Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Richard H. Reitz"'
Autor:
Kathleen P. Plotzke, Melvin E. Andersen, Robert H. Gallavan, Ivan D. Dobrev, Ramesh Sarangapani, Richard H. Reitz
Publikováno v:
Toxicological Sciences. 60:214-231
Octamethylcyclotetrasiloxane (D4) is an ingredient in selected consumer and precision cleaning products. Workplace inhalation exposures may occur in some D4 production operations. In this study, we analyzed tissue, plasma, and excreta time-course dat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de19c873ef6df7305fdeabb217a5dd23
https://doi.org/10.1093/toxsci/60.2.214
https://doi.org/10.1093/toxsci/60.2.214
Autor:
Richard H. Reitz, James S. Bus
Publikováno v:
Toxicology Letters. :669-676
Because of the expense involved in conducting chronic studies, limited numbers of animals and dose groups are used. This has given rise to the practice of including as one of the dose groups the “Maximum Tolerated Dose” (MTD). This dose is operat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aee6e38cb4276a048efc8bdd5d6e25b
https://doi.org/10.1016/0378-4274(92)90246-g
https://doi.org/10.1016/0378-4274(92)90246-g
Autor:
Alan L. Mendrala, Richard H. Reitz, Richard A. Corley, Melvin E. Andersen, Rory B. Conolly, Michael L. Gargas, J.F. Quast, Dee Ann Staats
Publikováno v:
Toxicology and Applied Pharmacology. 105:443-459
A physiologically based pharmacokinetic (PB-PK) model for CHCl3 has been used to prepare estimates of the probability that human populations exposed to low levels of CHCl3 will develop liver tumors similar to those seen in rodent bioassays. The PB-PK
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8886a57b29b18a062da16980afac52a
https://doi.org/10.1016/0041-008x(90)90148-n
https://doi.org/10.1016/0041-008x(90)90148-n
Autor:
Kathleen P. Plotzke, Justin G. Teeguarden, Ramesh Sarangapani, Richard H. Reitz, Melvin E. Andersen
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 71(1)
Octamethylcyclotetrasiloxane (D(4)) is used in selected consumer products and has a potential for human exposure from multiple routes. Here we develop a physiologically based pharmacokinetic (PBPK) model to describe the tissue dosimetry, plasma conce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed7ba609b95bfdc404f38222dc3a26ea
https://pubmed.ncbi.nlm.nih.gov/12520074
https://pubmed.ncbi.nlm.nih.gov/12520074
Autor:
Kimberly M. Thompson, Michael L. Gargas, M. D. Whorton, Joseph F. Holson, Christopher R. Kirman, Lisa M. Sweeney, Richard A. Corley, Richard H. Reitz, Tipton R. Tyler, Dennis J. Paustenbach
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 62(1)
Methoxyethanol (ethylene glycol monomethyl ether, EGME), ethoxyethanol (ethylene glycol monoethyl ether, EGEE), and ethoxyethyl acetate (ethylene glycol monoethyl ether acetate, EGEEA) are all developmental toxicants in laboratory animals. Due to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::806ce4085a11522f1c601d8b191800c9
https://pubmed.ncbi.nlm.nih.gov/11399800
https://pubmed.ncbi.nlm.nih.gov/11399800
Autor:
Melvin E. Andersen, F. Peter Guengerich, Richard H. Reitz, Harvey J. Clewell, M. W. Anders, Michael L. Gargas
Publikováno v:
Toxicology and Applied Pharmacology. 248:63-64
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::10efe9ada095cf11eb10ef0452417724
https://doi.org/10.1016/j.taap.2010.07.012
https://doi.org/10.1016/j.taap.2010.07.012
Publikováno v:
Toxicology and applied pharmacology. 137(2)
A physiologically based pharmacokinetic (PBPK) model capable of describing the metabolism of vinyl chloride (VC) in rats, mice, and humans has been developed and validated by comparison with experimental data from experiments not used in model develo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3fcbc53aaccbda39b5882bc37ad16a0
https://pubmed.ncbi.nlm.nih.gov/8661351
https://pubmed.ncbi.nlm.nih.gov/8661351
Publikováno v:
Toxicology and applied pharmacology. 136(2)
In vivo experiments in rats and mice and in vitro experiments in rats, mice, and humans have been used to develop and validate a "2nd generation" physiologically based pharmacokinetic (PBPK) model for perchloroethylene (PERC). The refined PBPK model
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69db4f404a6343096aa25f799d4e641d
https://pubmed.ncbi.nlm.nih.gov/8619237
https://pubmed.ncbi.nlm.nih.gov/8619237
Autor:
Michael L. Gargas, Richard H. Reitz, Michael G. MacNaughton, Melvin E. Andersen, Harvey J. Clewell, R. J. Nolan, M.J. McKenna
Publikováno v:
Toxicology and applied pharmacology. 108(1)
Dichloromethane (methylene chloride, DCM) and other dihalomethanes are metabolized to carbon monoxide (CO) which reversibly binds hemoglobin and is eliminated by exhalation. We have developed a physiologically based pharmacokinetic (PB-PK) model whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::336e788f355df89c81752d7c54e0875b
https://pubmed.ncbi.nlm.nih.gov/1900959
https://pubmed.ncbi.nlm.nih.gov/1900959