Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Richard H. Mueller"'
Autor:
Jing Liang, Yadagiri Pendri, Ramesh N. Patel, Amit Banerjee, Chung-Pin Chen, Richard H. Mueller
Publikováno v:
Tetrahedron: Asymmetry. 17:175-178
Enantioselective asymmetric hydrolysis of (1α,2β,3α)-2-(benzyloxymethyl)-cyclopent-4-ene-1,3-diol diacetate 1 to the corresponding (+)-monoacetate 2 was carried out using lipase PS-30 from Pseudomonas cepacia or pancreatin. A reaction yield of 85
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0bd18c9b269094b066d692acd2a8a0b5
https://doi.org/10.1016/j.tetasy.2005.08.061
https://doi.org/10.1016/j.tetasy.2005.08.061
Autor:
Jianqing Li, Linda Chu, Venkata B. Nanduri, Atul S. Kotnis, William L. Parker, Richard H. Mueller, Ramesh N. Patel, Mark Liu
Publikováno v:
Tetrahedron: Asymmetry. 16:2778-2783
The enantioselective microbial reduction of 6-oxo-8-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-8-azaspiro[4.5]decane-7,9-dione 1 to either of the corresponding (R)- or (S)-6-hydroxy-8-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-8-azaspiro[4.5]decane-7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c0ead0068215d5d10b0b70885eb1a3e
https://doi.org/10.1016/j.tetasy.2005.07.015
https://doi.org/10.1016/j.tetasy.2005.07.015
Autor:
Prasad J Siva, Linda Chu, Mary Jo Donovan, Ronald F Eiring, Robert J. Johnston, Richard H. Mueller, Ramesh N. Patel, Zhongping Shi, Junying Fan, Animesh Goswami, Brent Nielsen, Ambarish K. Singh, Kwok Y Wang, Dana L Cazzulino, Steven L. Goldberg, Weixuan He, Venkata B. Nanduri
Publikováno v:
Tetrahedron: Asymmetry. 15:1247-1258
The chiral intermediate ( S )-1-(2′-bromo-4′-fluoro phenyl)ethanol 2 was prepared by the enantioselective microbial reduction of 2-bromo-4-fluoro acetophenone 1 . Organisms from genus Candida , Hansenula , Pichia , Rhodotorula , Saccharomyces , S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3cf595c32f96d99f75563071b2336870
https://doi.org/10.1016/j.tetasy.2004.02.024
https://doi.org/10.1016/j.tetasy.2004.02.024
Autor:
Michael Totelben, Richard H. Mueller, Jollie D. Godfrey, James H. Simpson, Jason Hamm, Edward J. Delaney, Victor W. Rosso, Rajendra P. Deshpande, Atul S. Kotnis, Rita Fox, David J. Kacsur
Publikováno v:
Tetrahedron: Asymmetry. 14:3569-3574
Asymmetric cyclopropanation of styrene 1 (as the limiting reagent) was demonstrated using excess ethyl diazoacetate and catalytic Ru(ip-Pybox). Selective hydrolysis of the resulting 90:10 trans : cis mixture of cyclopropane 4 generated cyclopropyl ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b6daf43781bfc4eec1ae829be10209c2
https://doi.org/10.1016/j.tetasy.2003.08.041
https://doi.org/10.1016/j.tetasy.2003.08.041
Publikováno v:
Tetrahedron: Asymmetry. 14:3105-3109
The chiral intermediate (1S,2R)-[3-chloro-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid, 1,1-dimethylethyl ester 2a was prepared for the total synthesis of the HIV protease inhibitor Atazanavir. The diastereoselective reduction of (1S)-[3-chloro-2-o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50bc58fe16fd504922a0c53abf7b31ca
https://doi.org/10.1016/j.tetasy.2003.07.016
https://doi.org/10.1016/j.tetasy.2003.07.016
Autor:
Joseph Wurdinger, Theodor Denzel, Janak Singh, Chris G. Papaioannou, Richard H. Mueller, Rita Fox, Rolf Herter, Peter Schierling, Thomas P. Kissick, Jerome L. Moniot, Christopher M. Cimarusti
Publikováno v:
Organic Process Research & Development. 6:863-868
An efficient synthesis of the monobactam aztreonam [[2S-[2α,3β(Z)]]-3[[(2-amino-4-thiazolyl)[(1-carboxy-1-methylethoxy)imino]acetyl]amino]-2-methyl-4-oxo-1-azetidinesulfonic acid] (1) by acylation of α-aminoazetidinone 22 with the regioselectively
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d886af18b59af7bb47f35d3554c9f40
https://doi.org/10.1021/op025572d
https://doi.org/10.1021/op025572d
Process Research and Development for an Efficient Synthesis of the HIV Protease Inhibitor BMS-232632
Autor:
James E. Heikes, Mark D. Schwinden, Mark Lindrud, Michael J. Humora, Fernando Quiroz, David R. Kronenthal, Thomas P. Kissick, Bharat P. Patel, Sushil K. Srivastava, Dau-Ming Hsieh, Lin Dong, Janak Singh, Bin Zheng, Pudipeddi Madhusudhan, Zhongmin Xu, Richard H. Mueller
Publikováno v:
Organic Process Research & Development. 6:323-328
Development of an efficient and scalable process for the human immunodeficiency virus (HIV) protease inhibitor BMS-232632 1-[4-(pyridin-2-yl)phenyl]-5(S)-2,5-bis{[N-(methoxycarbonyl)-l-tert-leucinyl]-amino}-4(S)-hydroxy-6-phenyl-2-azahexane, is descr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50179c1c32a843ef9b7343fecb8439b4
https://doi.org/10.1021/op025504r
https://doi.org/10.1021/op025504r
Autor:
John D. Dimarco, Shankar Swaminathan, Brian Burke, Thomas P. Kissick, Oak K. Kim, Bin Zheng, Janak Singh, Kenneth J. Natalie, Goodrich Jason, Juliya Livshits, Matthew A. Brown, John A. Grosso, Zhinong Gao, Michael J. Humora, Anthony P. Dutka, Peter Hans Ermann, David R. Kronenthal, Gerard A. Crispino, Richard H. Mueller, John A. Wichtowski, Jeffrey T. North, Joanne J. Bronson, Jack Z. Gougoutas, Yasutsugu Ueda, Dane M. Springer, Peter Schierling, Bing Yu Luh, James E. Heikes, Dau-Ming Hsieh, Anne J. Pullockaran, Bo Zhang, Robert K. Perrone, Mei C. Lai, and Theodor W. Denzel, Yunhui Zhang
Publikováno v:
Organic Process Research & Development. 4:488-497
A practical synthesis of the anti-methicillin resistant Staphylococcus aureus cephem (6R-trans)-E-7-[[[[2,5-dichloro-4-[3-[(carboxymethyl)amino]-3-oxo-1-propenyl]phenyl]-thio]-acetyl]amino]-4-[[(2-carboxy-8-oxo-5-thia-1-azabicyclo-[4.2.0]oct-2-en-3-y
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::030fc232263c59de1340816a124920ab
https://doi.org/10.1021/op0002850
https://doi.org/10.1021/op0002850
Autor:
John A. Wichtowski, Yuan Tsai, Ken Denbleyker, Peter F. Misco, Jollie D. Godfrey, Janak Singh, Raymond F. Miller, Junius M. Clark, John D. Matiskella, Michael J. Pucci, Richard H. Mueller, Michael J. Humora, Boyhan Brenda T, Thomas P. Kissick, Joan Fung-Tomc, Stan V. D'Andrea, David R. Kronenthal, Robert K. Perrone, Yasutsuga Ueda, Annie Pullockaran, Murray A. Kaplan, Sterzycki Roman Z, James E. Heikes, Shelley E. Hoeft, Fritz Alan W, Truc Chi Vu, Rita Fox, Joanne J. Bronson, Jeffery T. North, D P Bonner, Thomas W. Hudyma
Publikováno v:
Tetrahedron. 56:5687-5698
Cephalosporin derivatives containing a unique combination of lipophilic C-7 sidechains and polar C-3 thiopyridinium groups were synthesized and found to exhibit potent anti-MRSA activity in vitro and in vivo. The optimum C-7 sidechains utilized were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::625ad66e9507d6b330714a80db975bfd
https://doi.org/10.1016/s0040-4020(00)00418-x
https://doi.org/10.1016/s0040-4020(00)00418-x
Autor:
Michael A. Poss, and Thomas P. Kissick, Michael J. Humora, Pansegrau Paul D, Boyhan Brenda T, Richard H. Mueller, John K. Thottathil, Shaopeng Wang, Janak Singh, Joy Q. Jannotti
Publikováno v:
Organic Process Research & Development. 1:14-19
A novel and highly efficient synthesis of [1S-(1α,2α,3α,4α)]-2-[[2-(3-methoxy-3-oxopropyl)phenyl]methyl]-7-oxabicyclo[2.2.1]heptane-3-carboxylic acid (A), a key intermediate in the synthesis of ifetroban sodium, BMS-180291, is described. Reaction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c18c7f149f12d9bc912e67332555272d
https://doi.org/10.1021/op960034k
https://doi.org/10.1021/op960034k