Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Richard H. Kline"'
Autor:
Michael J. Forster, Theresa A. Kopajtic, William L. Woolverton, Kenneth L. Alling, Gregory E. Agoston, Jonathan L. Katz, Richard H. Kline, Amy Hauck Newman
Publikováno v:
Psychopharmacology. 154:362-374
Rationale: Previous SAR studies demonstrated that small halogen substitutions on the diphenylether system of benztropine (BZT), such as a para-Cl group, retained high affinity at the cocaine binding site on the dopamine transporter. Despite this high
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa373569123e871c351cf293ca723be2
https://doi.org/10.1007/s002130000667
https://doi.org/10.1007/s002130000667
Autor:
James K. Rowlett, Kristin M. Wilcox, Jonathan L. Katz, William L. Woolverton, Richard H. Kline, Amy Hauck Newman, Ian A. Paul
Publikováno v:
Psychopharmacology. 147:426-435
Rationale: The reinforcing effects of many psychomotor stimulants have been related to increased dopaminergic neurotransmission. Drugs that block dopamine (DA) uptake have generally been found to function as positive reinforcers. Benztropine (BZT) an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b238b7c1bf91005935997cf53075c712
https://doi.org/10.1007/s002130050012
https://doi.org/10.1007/s002130050012
Publikováno v:
Journal of Medicinal Chemistry. 42:3502-3509
A series of phenyl ring-substituted analogues of 3alpha-(diphenylmethoxy)tropane (benztropine) has been prepared as novel probes for the dopamine transporter. Cross-validated comparative molecular field analysis (CoMFA) models of the binding domain o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63344a0f624f779fb814545586a431ec
https://doi.org/10.1021/jm980701v
https://doi.org/10.1021/jm980701v
Autor:
Clifford George, Andrew C. Allen, Sari Izenwasser, Jonathan L. Katz, Richard H. Kline, Amy Hauck Newman
Publikováno v:
Journal of Medicinal Chemistry. 38:3933-3940
A series of 4'-substituted and 4',4"-disubstituted 3 alpha-(diphenylmethoxy)tropane analogs were prepared as novel probes for the dopamine transporter. These compounds were evaluated in radiolabeled binding assays for the dopamine, norepinephrine, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82cf22b23378ad3d68cbd6f31cb83d5e
https://doi.org/10.1021/jm00020a006
https://doi.org/10.1021/jm00020a006
Autor:
Jeremy Wright, Christopher Q. Zhao, Kim R. Rogers, Richard H. Kline, Amira T. Eldefrawi, Nabil A. Anis, Mohyee E. Eldefrawi
Publikováno v:
Journal of Agricultural and Food Chemistry. 43:2308-2315
A fiber optic immunosensor, consisting of a quartz fiber coated with partially purified polyclonal anti-PCB antibodies (Abs), was used to detect polychlorinated biphenyls (PCBs). The optical signal was generated by the binding and subsequent fluoresc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::31b55055858277ff8f6d75c29ae605de
https://doi.org/10.1021/jf00056a064
https://doi.org/10.1021/jf00056a064
Publikováno v:
ChemInform. 29
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1bc29b283c0174b5be4f65e3aadfb797
https://doi.org/10.1002/chin.199826174
https://doi.org/10.1002/chin.199826174
Publikováno v:
Journal of Medicinal Chemistry. 34:702-705
Five (1R-2-exo-3-exo)-3-(N-phenylcarbamoyl)ecgonine methyl ester analogues were synthesized and characterized by 1H and 13C NMR, IR, and thermospray MS. The compounds were synthesized in two or three steps as (-)-stereoisomers from (-)-ecgonine in go
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef4886cce5cd9b52f062ebdb0d10f1ae
https://doi.org/10.1021/jm00106a035
https://doi.org/10.1021/jm00106a035
Publikováno v:
Journal of Medicinal Chemistry. 33:2024-2027
3-Arylecgonine analogues were synthesized and characterized by 1H and 13C NMR, IR, and MS. The compounds were synthesized as racemates from cycloheptatriene-7-carboxylic acid or enantiomerically from (-)-cocaine. These analogues were tested for their
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cc21ea9ca8c12d7495b4e071f7bab21
https://doi.org/10.1021/jm00169a036
https://doi.org/10.1021/jm00169a036
Autor:
Jae H. Wu, Jonathan L. Katz, Gregory E. Agoston, Clifford George, Sari Izenwasser, Richard H. Kline, Amy Hauck Newman
Publikováno v:
Journal of medicinal chemistry. 40(26)
A series of N-substituted 3 alpha-[bis(4'-fluorophenyl)methoxy]tropane analogues has been prepared that function as dopamine uptake inhibitors. The N-methylated analogue of this series had a significantly higher affinity for the dopamine transporter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::788c3885124b9d2713e5006c87620b05
https://pubmed.ncbi.nlm.nih.gov/9435902
https://pubmed.ncbi.nlm.nih.gov/9435902
Autor:
Sari Izenwasser, Richard H. Kline, Amy Hauck Newman, Jonathan L. Katz, David B. Joseph, Wayne D. Bowen
Publikováno v:
Journal of medicinal chemistry. 40(6)
A series of 2'- and 3'-substituted and 3',3"-disubstituted 3 alpha-(diphenylmethoxy)tropane analogs were designed and synthesized as novel probes for the dopamine transporter. All the analogs were evaluated for displacement of [3H]WIN 35,428 binding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf2b684f28f4bf5c71a8886dbdaf4115
https://pubmed.ncbi.nlm.nih.gov/9083473
https://pubmed.ncbi.nlm.nih.gov/9083473