Zobrazeno 1 - 10
of 225
pro vyhledávání: '"Richard H. Gomer"'
Autor:
Ramesh Rijal, Richard H. Gomer
Publikováno v:
Frontiers in Microbiology, Vol 15 (2024)
Mycobacterium tuberculosis (Mtb), the bacterium that causes tuberculosis (TB), can be difficult to treat because of drug tolerance. Increased intracellular polyphosphate (polyP) in Mtb enhances tolerance to antibiotics, and capsular polyP in Neisseri
Externí odkaz:
https://doaj.org/article/2994fc9c764545ac816e67b15665a8f6
Publikováno v:
mBio, Vol 14, Iss 5 (2023)
ABSTRACT Human macrophages and the eukaryotic microbe Dictyostelium discoideum ingest bacteria by phagocytosis, and then kill the ingested bacteria. Some pathogenic bacteria secrete linear chains of phosphate residues (polyphosphate; polyP), and the
Externí odkaz:
https://doaj.org/article/5b7961016a1c47cb8a6b75fb8e1fb8a8
Publikováno v:
Respiratory Research, Vol 23, Iss 1, Pp 1-12 (2022)
Abstract Background Sialic acid is often the distal sugar on glycoconjugates, and sialidases are enzymes that remove this sugar. In fibrotic lesions in human and mouse lungs, there is extensive desialylation of glycoconjugates, and upregulation of si
Externí odkaz:
https://doaj.org/article/daede1f497744dc4b867b7f035d23b31
Publikováno v:
JCI Insight, Vol 8, Iss 7 (2023)
Pulmonary fibrosis is potentiated by a positive feedback loop involving the extracellular sialidase enzyme neuraminidase 3 (NEU3) causing release of active TGF-β1 and TGF-β1 upregulating NEU3 by increasing translation without affecting mRNA levels.
Externí odkaz:
https://doaj.org/article/6706d838de8747ecb598d7667162c13a
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 6, p 5923 (2023)
Dictyostelium discoideum is a soil-dwelling unicellular eukaryote that accumulates extracellular polyphosphate (polyP). At high cell densities, when the cells are about to overgrow their food supply and starve, the corresponding high extracellular co
Externí odkaz:
https://doaj.org/article/6c0e112e504c4dc99be0a0d3fce06d23
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 1, p 239 (2022)
Fibrosing diseases are a major medical problem, and are associated with more deaths per year than cancer in the US. Sialidases are enzymes that remove the sugar sialic acid from glycoconjugates. In this review, we describe efforts to inhibit fibrosis
Externí odkaz:
https://doaj.org/article/6534dd3a59fd46ec991aae4ffbec5ed4
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Acute respiratory distress syndrome (ARDS) involves damage to lungs causing an influx of neutrophils from the blood into the lung airspaces, and the neutrophils causing further damage, which attracts more neutrophils in a vicious cycle. There are ∼
Externí odkaz:
https://doaj.org/article/2b2caf3ccf53416f8dee72bfe7f4c2e2
Autor:
Yu Tang, Ramesh Rijal, David E. Zimmerhanzel, Jacquelyn R. McCullough, Louis A. Cadena, Richard H. Gomer
Publikováno v:
mBio, Vol 12, Iss 3 (2021)
Many mammalian tissues such as the liver have the remarkable ability to regulate their size and have their cells stop proliferating when the tissue reaches the correct size. One possible mechanism involves the cells secreting a signal that they all s
Externí odkaz:
https://doaj.org/article/cd769e08364847d297279543191a45c4
Autor:
Richard H. Gomer
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 17, Iss , Pp 684-688 (2019)
Microbial communities are the simplest possible model of multicellular tissues, allowing studies of cell-cell interactions to be done with as few extraneous factors as possible. For instance, the eukaryotic microbe Dictyostelium discoideum proliferat
Externí odkaz:
https://doaj.org/article/636df6ec262a4ee8a21a145793ef286c
Publikováno v:
BMC Immunology, Vol 18, Iss 1, Pp 1-12 (2017)
Abstract Background Pentraxins are a family of highly conserved secreted proteins that regulate the innate immune system, including monocytes and macrophages. C-reactive protein (CRP) is a plasma protein whose levels can rise to 1000 μg/ml from the
Externí odkaz:
https://doaj.org/article/2da2fc62095443d68cc0e06606b488f7