Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Richard H. Fertel"'
Publikováno v:
Neurogastroenterology & Motility. 6:67-78
The aim of the study was to test the hypothesis that excitatory A2 and inhibitory A1 receptors coexist on myenteric AHIType 2 neurons, and are positively coupled to adenylate cyclase to stimulate cAMP formation. The A2 agonists NECA and CGS 21680 inc
Autor:
J. De Los Angeles, Victor I. Nikulin, Anish A. Konkar, Richard H. Fertel, Duane D. Miller, Dennis R. Feller, Seoung-Soo Hong
Publikováno v:
Pharmacology. 62:45-55
The biochemical activities of trimetoquinol (TMQ) analogs were evaluated at the human β1- and β3-adrenergic receptor (AR) subtypes expressed in Chinese hamster ovary cells. In radioligand binding assays, the 1-benzyl iodine-substituted analogs exhi
Autor:
Yong Pei, Lisa A. Barber, Robert C. Murphy, Christopher A. Johnson, Susan W. Kelley, Lady C. Dy, Richard H. Fertel, Thanh M. Nguyen, David A. Williams, Jeffrey B. Travers
Publikováno v:
The Journal of Immunology. 161:1954-1961
Recent studies suggest that the lipid mediator platelet-activating factor (PAF) is involved in keratinocyte function and skin inflammation. Indeed, PAF is found in association with inflammatory skin diseases, intradermal injections of PAF induce infl
Autor:
Larry R. Jones, George E. Billman, J. Hensley, Ruth A. Altschuld, Edward G. Lakatta, Rui-Ping Xiao, Richard H. Fertel, Pierre Marie L. Robitaille, C. M. Hohl, Robert L. Hamlin, L. C. Castillo, Randall C. Starling
Publikováno v:
Circulation. 92:1612-1618
Background Failing human hearts lose β 1 - but not β 2 -adrenergic receptors. In canine hearts with tachypacing failure, the ratio of β 2 - to β 1 -adrenergic receptors is increased. The present study was designed to determine whether heart failu
Autor:
Duane D. Miller, Dennis R. Feller, Edwin J. Lezama, M. Margarita Salazar‐Bookaman, Richard H. Fertel, Paul F. Fraundorfer
Publikováno v:
Chirality. 6:76-85
Trimetoquinol [1-(3',4',5'-trimethoxybenzyl)-6,7-dihydroxy-1,2,3,4- tetrahydroisoquinoline , TMQ] exists as two enantiomers, and the (-)-(S)-isomer is a potent beta-adrenergic receptor (beta-AR) agonist. Experiments were conducted to examine the func
Publikováno v:
Cardiovascular Research. 27:238-242
Objective: The aim was to compare β adrenergic receptors, cAMP production, and Ca2+ accumulation by the sarcoplasmic reticulum in ventricular cardiomyocytes from female SHHF/Mcc- cp and JCR:LA- cp rats. Whereas rats from both strains exhibit gross o
Publikováno v:
International Journal of Immunopharmacology. 14:515-523
Carbamyl-platelet-activating factor (1-hexadecyl-2-N-methylcarbamyl-glycero-3-phosphocholine; CPAF) is an analog of platelet-activating factor (PAF) containing an N-methylcarbamyl moiety at the sn-2 position. CPAF was tested for effects on the Raji l
Publikováno v:
Archives of Biochemistry and Biophysics. 292:112-120
MOLT-4 lymphocytes metabolize 12-hydroxy-5,8,10,14-eicosatetraenoic acid (12( S )-HETE via β-oxidation with retention of the hydroxyl group at the ω9 carbon atom. The isolation of 6-hydroxy-4,8-tetradecadienoic acid documents that these cells have
Publikováno v:
American Journal of Obstetrics and Gynecology. 166:236-241
OBJECTIVE: The purpose of this study was to test the hypothesis that catecholamines can modulate epidermal growth factor-induced prostaglandin E 2 production in amnion-derived cells via a cyclic adenosine monophosphate-dependent pathway. STUDY DESIGN
Publikováno v:
European Journal of Pharmacology: Molecular Pharmacology. 206:231-236
Enzymatically dissociated ganglia from the myenteric plexus of the guinea-pig small intestine were used to investigate changes in levels of cyclic 3',5'-adenosine monophosphate (cAMP) in response to stimulation of adenylate cyclase by forskolin and i