Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Richard H. Alper"'
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 77:76-80
Introduction The purpose of these studies was to describe a novel application of an automated data acquisition/data reduction system, DanioVision™ by Noldus. DanioVision™ has the ability to detect changes in locomotor activity in third instar Dro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09570ec003f5c35fa49ed7405f773434
https://doi.org/10.1016/j.vascn.2015.10.004
https://doi.org/10.1016/j.vascn.2015.10.004
Publikováno v:
European Journal of Pharmacology. 579:225-228
Antimuscarinics are first-line pharmacotherapy for the treatment of overactive bladder. However, because central nervous system cholinergic neurotransmission is involved in cognition, and the central nervous system-permeable antimuscarinics scopolami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a51ac0784ba2ae925e83e3caf77e7dd
https://doi.org/10.1016/j.ejphar.2007.10.063
https://doi.org/10.1016/j.ejphar.2007.10.063
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 56:218-222
Introduction Rats are used in drug safety because they satisfy regulatory guidelines, there is a large historical database, and their cardiovascular systems respond similarly to humans. The use of radiotelemetry offers a variety of advantages over no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c2643435a4e9490293b6c665491cf55
https://doi.org/10.1016/j.vascn.2007.04.006
https://doi.org/10.1016/j.vascn.2007.04.006
Publikováno v:
The FASEB Journal. 29
The noncompetitive GABAA receptor antagonist picrotoxin (PTX) decreases activity in 3rd instar Drosophila larvae (Eur J Neurosci, 2006). The purpose of these studies was to replicate the data obtained by Stilwell et al. using an automated data acquis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::099415cbd11f173d7d0b562b45e2ea8f
https://doi.org/10.1096/fasebj.29.1_supplement.615.2
https://doi.org/10.1096/fasebj.29.1_supplement.615.2
Publikováno v:
Neuroendocrinology. 73:166-174
Previously our laboratory has shown that 17β-estradiol in vivo rapidly decreases R(+)-8-OH-DPAT-stimulated [35S]GTPγS binding (a measure of the initial biochemical event in the intracellular signaling pathway associated with 5-HT1A receptors) in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::edf12c2115b87e40f6ae2ed5df068da9
https://doi.org/10.1159/000054633
https://doi.org/10.1159/000054633
Publikováno v:
European Journal of Pharmacology. 392:125-128
Functional consequences of receptor stimulation by quinpirole, a dopamine D 2 -like receptor agonist, were assessed using agonist-stimulated [ 35 S]GTPγS binding in rat striatal membranes. Dopamine receptor antagonists inhibited quinpirole-stimulate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7784b31f49abfb9530ec9cb22847ca0f
https://doi.org/10.1016/s0014-2999(00)00124-2
https://doi.org/10.1016/s0014-2999(00)00124-2
Autor:
Amy L. Mize, Richard H. Alper
Publikováno v:
Brain Research. 859:326-333
Estrogens exert effects on mood, mental state, memory and other central nervous system (CNS) functions by modulating neurotransmitter receptor systems in the brain. Studies were designed to investigate the effect of 17beta-estradiol (E(2)) on agonist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3c608bf7555f31815c2cf81b15ae0cd
https://doi.org/10.1016/s0006-8993(00)01998-3
https://doi.org/10.1016/s0006-8993(00)01998-3
Autor:
Richard H. Alper, David L. Nelson
Publikováno v:
European Journal of Pharmacology. 390:67-73
5-HT 1A receptor function can be assessed in rat hippocampal and cortical membrane preparations as agonist-stimulated [ 35 S]GTPγS binding. Membranes were preincubated in vitro with N -ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ). R (+)-8-hyd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::017843de6655b79ae07f8e9b39994e5a
https://doi.org/10.1016/s0014-2999(00)00032-7
https://doi.org/10.1016/s0014-2999(00)00032-7
Autor:
Amy L. Mize, Richard H. Alper
Publikováno v:
Brain Research. 836:229-236
Serotonin (5-hydroxytryptamine; 5-HT) receptor ligands were used to assess agonist-stimulated [ 35 S]GTPγS binding in rat and guinea pig striatal membranes. The assay contained 45–60 μg protein, 300 μM GDP and 0.1 nM [ 35 S]GTPγS, incubated at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2f05e87b32d12b5a045201a32869205
https://doi.org/10.1016/s0006-8993(99)01660-1
https://doi.org/10.1016/s0006-8993(99)01660-1
Autor:
David L. Nelson, Richard H. Alper
Publikováno v:
European Journal of Pharmacology. 343:303-312
Stimulation of [ 35 S ]GTPγS binding by serotonin (5-hydroxytryptamine, 5-HT) receptor ligands was characterized in rat hippocampal membranes. The optimized assay contained 30–50 μg protein, 300 μM GDP and 0.1 nM [ 35 S ]GTPγS, incubated at 37
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5fd38872e2c87e80610a50ebef6866fb
https://doi.org/10.1016/s0014-2999(97)01547-1
https://doi.org/10.1016/s0014-2999(97)01547-1