Zobrazeno 1 - 10
of 227
pro vyhledávání: '"Richard H Gomer"'
Publikováno v:
F1000Research, Vol 11 (2022)
Background: Dictyostelium discoideum is a ~10 µm diameter unicellular eukaryote that lives on soil surfaces. When starved, D. discoideum cells aggregate into streams of cells in a process called chemotaxis. In this report, we studied D. discoideum c
Externí odkaz:
https://doaj.org/article/9ece662a5e8e44439869442a0fc5a480
Autor:
Yu Tang, Richard H Gomer
Publikováno v:
BioTechniques, Vol 68, Iss 3, Pp 163-165 (2020)
Shotgun expression of antisense cDNA, where each transformed cell expresses a different antisense cDNA, has been used for mutagenesis and gene identification in Dictyostelium discoideum. However, the method has two limitations. First, there were too
Externí odkaz:
https://doaj.org/article/141541ed4b2843debfc028daa66ac171
Publikováno v:
PLoS ONE, Vol 16, Iss 1, p e0245924 (2021)
SARS-CoV-2 is a single stranded RNA (ssRNA) virus and contains GU-rich sequences distributed abundantly in the genome. In COVID-19, the infection and immune hyperactivation causes accumulation of inflammatory immune cells, blood clots, and protein ag
Externí odkaz:
https://doaj.org/article/681ddbd13e6046fd83e61726fb66fc83
Publikováno v:
PLoS ONE, Vol 15, Iss 12, p e0244762 (2020)
Non-alcoholic fatty liver disease (NAFLD) is associated with obesity and type 2 diabetes and is characterized by the accumulation of fat in the liver (steatosis). NAFLD can transition into non-alcoholic steatohepatitis (NASH), with liver cell injury,
Externí odkaz:
https://doaj.org/article/81cb22177e3c4508a70e3c580c204ed5
Publikováno v:
Therapeutics and Clinical Risk Management, Vol 2011, Iss default, Pp 39-47 (2011)
Ye Gan1,2, Erica L Herzog2, Richard H Gomer31Department of Medicine, Central South University, Changsha, Hunan, China; 2Department of Medicine, Yale University School of Medicine, New Haven, CT, USA; 3Department of Biology, Texas A&M University, Coll
Externí odkaz:
https://doaj.org/article/40547fa630e247449e2dd8c13f89d63d
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0119709 (2015)
Monocyte-derived, fibroblast-like cells called fibrocytes are associated with fibrotic lesions. The plasma protein serum amyloid P component (SAP; also known as pentraxin-2, PTX2) inhibits fibrocyte differentiation in vitro, and injections of SAP inh
Externí odkaz:
https://doaj.org/article/81b35b40309848088313945e2667bfa0
Autor:
Michael J V White, Richard H Gomer
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0138748 (2015)
For both wound healing and the formation of a fibrotic lesion, circulating monocytes enter the tissue and differentiate into fibroblast-like cells called fibrocytes and pro-fibrotic M2a macrophages, which together with fibroblasts form scar tissue. M
Externí odkaz:
https://doaj.org/article/11c7612dfa2547458b27fdf4bc412186
Autor:
Darrell Pilling, Richard H Gomer
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e93730 (2014)
Fibrosing diseases, such as pulmonary fibrosis, cardiac fibrosis, myelofibrosis, liver fibrosis, and renal fibrosis are chronic and debilitating conditions and are an increasing burden for the healthcare system. Fibrosis involves the accumulation and
Externí odkaz:
https://doaj.org/article/4db794f42b0243f3b7775232ba2f0ab3
Autor:
John Daniel DeBord, Donald F Smith, Christopher R Anderton, Ron M A Heeren, Ljiljana Paša-Tolić, Richard H Gomer, Francisco A Fernandez-Lima
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e99319 (2014)
High resolution imaging mass spectrometry could become a valuable tool for cell and developmental biology, but both, high spatial and mass spectral resolution are needed to enable this. In this report, we employed Bi3 bombardment time-of-flight (Bi3
Externí odkaz:
https://doaj.org/article/a75ee44d40cd451ebdb2ee6256612ec4
Autor:
Jonathan E Phillips, Richard H Gomer
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e96633 (2014)
In Dictyostelium discoideum, the secreted proteins AprA and CfaD function as reporters of cell density and regulate cell number by inhibiting proliferation at high cell densities. AprA also functions to disperse groups of cells at high density by act
Externí odkaz:
https://doaj.org/article/c5f123763e5549e7b9935350e9b9505b