Zobrazeno 1 - 10
of 216
pro vyhledávání: '"Richard H, Ebright"'
Autor:
Andrew Cheng, Danny Wan, Arkaprabha Ghatak, Chengyuan Wang, Deyu Feng, Joseph D. Fondell, Richard H. Ebright, Huizhou Fan
Publikováno v:
mBio, Vol 14, Iss 1 (2023)
ABSTRACT Gene transcription in bacteria is carried out by the multisubunit RNA polymerase (RNAP), which is composed of a catalytic core enzyme and a promoter-recognizing σ factor. The core enzyme comprises two α subunits, one β subunit, one β′
Externí odkaz:
https://doaj.org/article/e33bc81ba9064c8e9615bb14dc4c9865
Blocks in the pseudouridimycin pathway unlock hidden metabolites in the Streptomyces producer strain
Autor:
Marianna Iorio, Sahar Davatgarbenam, Stefania Serina, Paolo Criscenzo, Mitja M. Zdouc, Matteo Simone, Sonia I. Maffioli, Richard H. Ebright, Stefano Donadio, Margherita Sosio
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract We report a metabolomic analysis of Streptomyces sp. ID38640, a soil isolate that produces the bacterial RNA polymerase inhibitor pseudouridimycin. The analysis was performed on the wild type, on three newly constructed and seven previously
Externí odkaz:
https://doaj.org/article/bf5c6c742b4b4ec79d73fdd145693768
Publikováno v:
eLife, Vol 10 (2021)
Transcription initiation starts with unwinding of promoter DNA by RNA polymerase (RNAP) to form a catalytically competent RNAP-promoter complex (RPo). Despite extensive study, the mechanism of promoter unwinding has remained unclear, in part due to t
Externí odkaz:
https://doaj.org/article/a30f5b4d3ff2433d975fec7b77a92d47
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
No structural data have been available for RNA polymerase holoenzymes or transcription initiation complexes that contain extracytoplasmic σ factors. Here the authors report the crystal structures of transcription initiation complexes comprising Myco
Externí odkaz:
https://doaj.org/article/f55e90aaf41f47288c3b2ad96204bc88
Autor:
Yassin M. Elbatrawi, Taylor Gerrein, Avraz Anwar, Kamlesh M. Makwana, David Degen, Richard H. Ebright, Juan R. Del Valle
Publikováno v:
Organic Letters. 24:9285-9289
We report the total synthesis and configurational assignment of pargamicin A, a highly oxidized nonribosomal peptide that potently inhibits the growth of drug-resistant bacteria. Our synthetic approach relies on late-stage piperazine ring formation a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::134fc62f4f5fd00936af8333966b3895
https://doi.org/10.1021/acs.orglett.2c03861
https://doi.org/10.1021/acs.orglett.2c03861
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Transcription elongation by RNA polymerase (RNAP) is interspersed with sequence-dependent pausing which is difficult to study due to spatiotemporal limitations of available methods. Here authors use a high-resolution optical tweezers assay and find t
Externí odkaz:
https://doaj.org/article/4f02b5bce35947fabd2aa1bed87b067f
Autor:
Jeremy G Bird, Urmimala Basu, David Kuster, Aparna Ramachandran, Ewa Grudzien-Nogalska, Atif Towheed, Douglas C Wallace, Megerditch Kiledjian, Dmitry Temiakov, Smita S Patel, Richard H Ebright, Bryce E Nickels
Publikováno v:
eLife, Vol 7 (2018)
Bacterial and eukaryotic nuclear RNA polymerases (RNAPs) cap RNA with the oxidized and reduced forms of the metabolic effector nicotinamide adenine dinucleotide, NAD+ and NADH, using NAD+ and NADH as non-canonical initiating nucleotides for transcrip
Externí odkaz:
https://doaj.org/article/57aac7a5967f43ecb1ef76a3ed32e3c3
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(33)
Lambdoid bacteriophage Q proteins are transcription antipausing and antitermination factors that enable RNA polymerase (RNAP) to read through pause and termination sites. Q proteins load onto RNAP engaged in promoter-proximal pausing at a Q binding e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baa56448d5f6809509bf928e07625563
https://pubmed.ncbi.nlm.nih.gov/35951650
https://pubmed.ncbi.nlm.nih.gov/35951650
Autor:
Tian Lan, Uday S. Ganapathy, Sachin Sharma, Yong‐Mo Ahn, Matthew Zimmerman, Vadim Molodtsov, Pooja Hegde, Martin Gengenbacher, Richard H. Ebright, Véronique Dartois, Joel S. Freundlich, Thomas Dick, Courtney C. Aldrich
Publikováno v:
Angewandte Chemie International Edition. 61
Rifamycin antibiotics are a valuable class of antimicrobials for treating infections by mycobacteria and other persistent bacteria owing to their potent bactericidal activity against replicating and non-replicating pathogens. However, the clinical ut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37fdf33208a09d06d9843a1a08fc77dd
https://doi.org/10.1002/anie.202211498
https://doi.org/10.1002/anie.202211498
Autor:
Andrew Cheng, Danny Wan, Arkaprabha Ghatak, Chengyuan Wang, Deyu Feng, Joseph D. Fondell, Richard H. Ebright, Huizhou Fan
Gene transcription in bacteria is carried out by the multisubunit RNA polymerase (RNAP), which is composed of a catalytic core enzyme and a promoter-recognizing σ factor. RNAP core enzyme comprises two α subunits, one β subunit, one β’ s subuni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a4bea345b0d07931e0e30201bb98e187
https://doi.org/10.1101/2022.09.22.509108
https://doi.org/10.1101/2022.09.22.509108
