Zobrazeno 1 - 10
of 351
pro vyhledávání: '"Richard Grundy"'
Autor:
James T. Grist, Stephanie Withey, Christopher Bennett, Heather E. L. Rose, Lesley MacPherson, Adam Oates, Stephen Powell, Jan Novak, Laurence Abernethy, Barry Pizer, Simon Bailey, Steven C. Clifford, Dipayan Mitra, Theodoros N. Arvanitis, Dorothee P. Auer, Shivaram Avula, Richard Grundy, Andrew C. Peet
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Brain tumors represent the highest cause of mortality in the pediatric oncological population. Diagnosis is commonly performed with magnetic resonance imaging. Survival biomarkers are challenging to identify due to the relatively low numbers
Externí odkaz:
https://doaj.org/article/65b300bcf0904636b1d39deb984c2b8c
Autor:
Huda Alfardus, Maria de los Angeles Estevez-Cebrero, Jonathan Rowlinson, Amna Aboalmaaly, Anbarasu Lourdusamy, Salah Abdelrazig, Catherine Ortori, Richard Grundy, Dong-Hyun Kim, Alan McIntyre, Stuart Smith
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract While specific microRNA (miRNA) signatures have been identified in glioblastoma (GBM), the intratumour heterogeneity in miRNA expression has not yet been characterised. In this study, we reveal significant alterations in miRNA expression acr
Externí odkaz:
https://doaj.org/article/70c79d13cb784e25885855238a077df2
Autor:
Jan Novak, Niloufar Zarinabad, Heather Rose, Theodoros Arvanitis, Lesley MacPherson, Benjamin Pinkey, Adam Oates, Patrick Hales, Richard Grundy, Dorothee Auer, Daniel Rodriguez Gutierrez, Tim Jaspan, Shivaram Avula, Laurence Abernethy, Ramneek Kaur, Darren Hargrave, Dipayan Mitra, Simon Bailey, Nigel Davies, Christopher Clark, Andrew Peet
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
Abstract To determine if apparent diffusion coefficients (ADC) can discriminate between posterior fossa brain tumours on a multicentre basis. A total of 124 paediatric patients with posterior fossa tumours (including 55 Medulloblastomas, 36 Pilocytic
Externí odkaz:
https://doaj.org/article/ceb6c559134f49fa9d1b2048f5539650
Autor:
Mahdi Nohtani, Katerina Vrzalikova, Maha Ibrahim, Judith E. Powell, Éanna Fennell, Susan Morgan, Richard Grundy, Keith McCarthy, Sarah Dewberry, Jan Bouchal, Katerina Bouchalova, Pamela Kearns, Paul G. Murray
Publikováno v:
Cancers, Vol 14, Iss 17, p 4297 (2022)
In this study, we have re-evaluated how EBV status influences clinical outcome. To accomplish this, we performed a literature review of all studies that have reported the effect of EBV status on patient outcome and also explored the effect of EBV pos
Externí odkaz:
https://doaj.org/article/2a2fc61068a64cf8a588734ac982dbf3
Autor:
Joshua Branter, Maria Estevez-Cebrero, Mohammed Diksin, Michaela Griffin, Marcos Castellanos-Uribe, Sean May, Ruman Rahman, Richard Grundy, Surajit Basu, Stuart Smith
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 4, p 1982 (2022)
The lack of treatment options for high-grade brain tumors has led to searches for alternative therapeutic modalities. Electrical field therapy is one such area. The Optune™ system is an FDA-approved novel device that delivers continuous alternating
Externí odkaz:
https://doaj.org/article/a892aff8db5e4c4080049d905839d451
Autor:
James T. Grist, Stephanie Withey, Lesley MacPherson, Adam Oates, Stephen Powell, Jan Novak, Laurence Abernethy, Barry Pizer, Richard Grundy, Simon Bailey, Dipayan Mitra, Theodoros N. Arvanitis, Dorothee P. Auer, Shivaram Avula, Andrew C Peet
Publikováno v:
NeuroImage: Clinical, Vol 25, Iss , Pp - (2020)
The imaging and subsequent accurate diagnosis of paediatric brain tumours presents a radiological challenge, with magnetic resonance imaging playing a key role in providing tumour specific imaging information. Diffusion weighted and perfusion imaging
Externí odkaz:
https://doaj.org/article/4a7b8226810c4e8fb6480effcc9ea7db
Autor:
Felipe Andreiuolo, Gwénaël Le Teuff, Mohamed Amine Bayar, John-Paul Kilday, Torsten Pietsch, André O von Bueren, Hendrik Witt, Andrey Korshunov, Piergiorgio Modena, Stefan M Pfister, Mélanie Pagès, David Castel, Felice Giangaspero, Leila Chimelli, Pascale Varlet, Stefan Rutkowski, Didier Frappaz, Maura Massimino, Richard Grundy, Jacques Grill, SIOP Ependymoma Biology Working Group BIOMECA (BIOlogical Markers for Ependymomas in Children and Adolescents)
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0178351 (2017)
Despite multimodal therapy, prognosis of pediatric intracranial ependymomas remains poor with a 5-year survival rate below 70% and frequent late deaths.This multicentric European study evaluated putative prognostic biomarkers. Tenascin-C (TNC) immuno
Externí odkaz:
https://doaj.org/article/4031726ec5d04c98b907cb7ee55d615b
Autor:
Young Seok Ju, Ludmil B Alexandrov, Moritz Gerstung, Inigo Martincorena, Serena Nik-Zainal, Manasa Ramakrishna, Helen R Davies, Elli Papaemmanuil, Gunes Gundem, Adam Shlien, Niccolo Bolli, Sam Behjati, Patrick S Tarpey, Jyoti Nangalia, Charles E Massie, Adam P Butler, Jon W Teague, George S Vassiliou, Anthony R Green, Ming-Qing Du, Ashwin Unnikrishnan, John E Pimanda, Bin Tean Teh, Nikhil Munshi, Mel Greaves, Paresh Vyas, Adel K El-Naggar, Tom Santarius, V Peter Collins, Richard Grundy, Jack A Taylor, D Neil Hayes, David Malkin, ICGC Breast Cancer Group, ICGC Chronic Myeloid Disorders Group, ICGC Prostate Cancer Group, Christopher S Foster, Anne Y Warren, Hayley C Whitaker, Daniel Brewer, Rosalind Eeles, Colin Cooper, David Neal, Tapio Visakorpi, William B Isaacs, G Steven Bova, Adrienne M Flanagan, P Andrew Futreal, Andy G Lynch, Patrick F Chinnery, Ultan McDermott, Michael R Stratton, Peter J Campbell
Publikováno v:
eLife, Vol 3 (2014)
Recent sequencing studies have extensively explored the somatic alterations present in the nuclear genomes of cancers. Although mitochondria control energy metabolism and apoptosis, the origins and impact of cancer-associated mutations in mtDNA are u
Externí odkaz:
https://doaj.org/article/a97bb2e0fa0f4eb19b17cd3f405b0385
Autor:
Stephen J. Powell, Stephanie B. Withey, Yu Sun, James T. Grist, Jan Novak, Lesley MacPherson, Laurence Abernethy, Barry Pizer, Richard Grundy, Paul S. Morgan, Tim Jaspan, Simon Bailey, Dipayan Mitra, Dorothee P. Auer, Shivaram Avula, Theodoros N. Arvanitis, Andrew Peet
Publikováno v:
The British Journal of Radiology. 96
Objective: Investigate the performance of qualitative review (QR) for assessing dynamic susceptibility contrast (DSC-) MRI data quality in paediatric normal brain and develop an automated alternative to QR. Methods: 1027 signal–time courses were as
Autor:
Michael D. Taylor, Anna Marie Kenney, Carlo M. Croce, James T. Rutka, Timothy Van Meter, Richard Grundy, Yancey Gillespie, Wesia Grajkowska, David W. Ellison, John P. Hagan, Africa Fernandez-L, Paul A. Northcott
Medulloblastoma is the most common malignant pediatric brain tumor, and mechanisms underlying its development are poorly understood. We identified recurrent amplification of the miR-17/92 polycistron proto-oncogene in 6% of pediatric medulloblastomas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::422c20ab46af1f3609b915d735409a00
https://doi.org/10.1158/0008-5472.c.6499689.v1
https://doi.org/10.1158/0008-5472.c.6499689.v1