Myeloid A20 is critical for alternative macrophage polarization and type-2 immune-mediated helminth resistance

Autor: Ioanna Petta, Marie Thorp, Maarten Ciers, Gillian Blancke, Louis Boon, Tim Meese, Filip Van Nieuwerburgh, Andy Wullaert, Richard Grencis, Dirk Elewaut, Geert van Loo, Lars Vereecke

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

BackgroundProtective immunity against intestinal helminths requires induction of robust type-2 immunity orchestrated by various cellular and soluble effectors which promote goblet cell hyperplasia, mucus production, epithelial proliferation, and smoo

Externí odkaz: https://doaj.org/article/4430a9dec9a04b37b1e9e9b55eb09f9c

The TGFβ-activating integrin αvβ8 on dendritic cells regulates type 2 immunity in the intestine to promote chronic parasitic infection (P3318)

Autor: John Worthington, Joanna Klementowicz, Sayema Rahman, Beata Czajkowska, Herman Waldmann, Tim Sparwasser, Richard Grencis, Mark Travis

Publikováno v: The Journal of Immunology. 190:134.12-134.12

The cytokine TGFβ is crucial in regulating immunity in the intestine, but its role and regulation during responses to intestinal infection is not well understood. We therefore addressed how TGFβ functions and is controlled during chronic intestinal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::23a0e73ad4395c20ccec64396f60266c
https://doi.org/10.4049/jimmunol.190.supp.134.12

IL-17A both initiates, via IFNγ suppression, and limits the pulmonary type 2 immune response to nematode infection

Autor: Jesuthas Ajendra, Alistair Chenery, Parkinson, James E., Brian Chan, Stella Pearson, Stefano Adriano Colombo, Louis Boon, Richard Grencis, Sutherland, Tara E., Judith Allen

Publikováno v: University of Manchester-PURE
Ajendra, J, Chenery, A, Parkinson, J, Chan, B H K, Pearson, S, Colombo, S, Boon, L, Grencis, R, Sutherland, T & Allen, J 2020, ' IL-17A both initiates, via IFNγ suppression, and limits the pulmonary type 2 immune response to nematode infection ', Mucosal Immunology, vol. 13, pp. 958–968 . < https://www.nature.com/articles/s41385-020-0318-2 >

Nippostrongylus brasiliensis is a well-defined model of type-2 immunity but the early lung migrating phase is dominated by innate IL-17A production. In this study, we confirm previous observations that Il17a-KO mice infected with N. brasiliensis exhi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::2770d0c919ad66c60d80549817742866
https://www.researchtest.ppad.man.ac.uk/portal/en/publications/il17a-both-initiates-via-ifn-suppression-and-limits-the-pulmonary-type-2-immune-response-to-nematode-infection(9ab480da-f247-4064-9230-ccc4a11cd993).html