Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Richard Grater"'
Autor:
Christopher Rowbottom, Alicia Pietrasiewicz, Taras Tuczewycz, Richard Grater, Daniel Qiu, Sudarshan Kapadnis, Patrick Trapa
Publikováno v:
Pharmacology Research & Perspectives, Vol 9, Iss 2, Pp n/a-n/a (2021)
Abstract Transporters can play a key role in the absorption, distribution, metabolism, and excretion of drugs. Understanding these contributions early in drug discovery allows for more accurate projection of the clinical pharmacokinetics. One method
Externí odkaz:
https://doaj.org/article/103f00bec9d940f988399c1ce77485f6
Autor:
Cheng Fang, Ye Wang, Richard Grater, Sudarshan Kapadnis, Cheryl Black, Patrick Trapa, Simone Sciabola
Publikováno v:
Journal of Chemical Information and Modeling.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c671bb3f0d8fca384821c9438239de00
https://doi.org/10.1021/acs.jcim.3c00160
https://doi.org/10.1021/acs.jcim.3c00160
Autor:
Bin Ma, Urjana Poreci, Luisette Delva, Fengmei Zhang, Hao Tang, Tonika Bohnert, Patricia Schroeder, Richard Grater, Sudarshan Kapadnis, Kris King, Michael Mingueneau, Marc Hoemberger, Evelyne Polack, Brian T. Hopkins, Prince Robin, Chris Rowbottom, Robert Meissner, Eris Bame, Joseph C Santoro, Paramasivam Murugan, Allie M Roach, Claire M. Metrick, Kevin L. Otipoby, Eric Tien, Josh Johnson, Douglas Donaldson, Joseph P. Lyssikatos, Doug Burdette, Tom Magee, Carrie Boiselle, Chungang Gu, Mukesh Lulla, Bekim Bajrami, Jeremy C. Burns, Cheryl Black, Marx Isaac
Publikováno v:
Journal of medicinal chemistry. 65(2)
Multiple Sclerosis is a chronic autoimmune neurodegenerative disorder of the central nervous system (CNS) that is characterized by inflammation, demyelination, and axonal injury leading to permeant disability. In the early stage of MS, inflammation i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d73da50c6f550d3e41002d416b5cebb6
https://pubmed.ncbi.nlm.nih.gov/34734694
https://pubmed.ncbi.nlm.nih.gov/34734694
Autor:
Sudarshan Kapadnis, Patrick Trapa, Richard Grater, Daniel Qiu, Taras Tuczewycz, Christopher Rowbottom, Alicia Pietrasiewicz
Publikováno v:
Pharmacology Research & Perspectives
Pharmacology Research & Perspectives, Vol 9, Iss 2, Pp n/a-n/a (2021)
Pharmacology Research & Perspectives, Vol 9, Iss 2, Pp n/a-n/a (2021)
Transporters can play a key role in the absorption, distribution, metabolism, and excretion of drugs. Understanding these contributions early in drug discovery allows for more accurate projection of the clinical pharmacokinetics. One method to assess
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60a2ee10faed30def67aa2b2127bd820
http://europepmc.org/articles/PMC7931226
http://europepmc.org/articles/PMC7931226
Autor:
Tonika Bohnert, Chris Rowbottom, Guangqing XiaoPreclinical Pharmacokinetics, Richard Grater, Ellen Rohde, Roger Rusesabagina, Luisette Delva, Cheryl Black, Elvana Veizaj, Qin Wang, Patricia Schroeder
Publikováno v:
Journal of Neurology & Neuromedicine. 3:51-56
Objective: The convective flow of CSF plays a crucial role for CNS to clear endogenous and xenobiotic substances. The objective of this study is to investigate the impact of modifying CSF flow with acetazolamide and arginine vasopressin (AVP) on the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3cfcd1d3c1a42f9618e5e538550f64e2
https://doi.org/10.29245/2572.942x/2018/5.1217
https://doi.org/10.29245/2572.942x/2018/5.1217
Autor:
Richard Grater, Barbara LeDuc, Lawrence L. Gan, Mukesh Lulla, David A. Williams, Tonika Bohnert, Abdul Naveed Shaik
Publikováno v:
Journal of Chromatography B. 1008:164-173
Warfarin is an anticoagulant used in the treatment of thrombosis and thromboembolism. It is given as a racemic mixture of R and S enantiomers. These two enantiomers show differences in metabolism by CYPs: S-warfarin undergoes 7 hydroxylation by CYP2C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9cb031cd3feb0db67fd82f2bf4dccca
https://doi.org/10.1016/j.jchromb.2015.11.036
https://doi.org/10.1016/j.jchromb.2015.11.036
Autor:
Alicia Pietrasiewicz, Taras Tuczkewycz, Sudarshan Kapadnis, Richard Grater, Christopher Rowbottom, Daniel Qiu, Doug Burdette, Elvana Viezaj
Publikováno v:
Drug Metabolism and Pharmacokinetics. 35:S62
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5f472d5a0170797247e4fe2e3cc05658
https://doi.org/10.1016/j.dmpk.2020.04.132
https://doi.org/10.1016/j.dmpk.2020.04.132
Autor:
Olga Golonzhka, Michael Rooney, Greg Dillon, Christopher Rowbottom, Richard Grater, Kristopher W King, Michael Calhoun
Publikováno v:
Drug Metabolism and Pharmacokinetics. 34:S31
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ac547d1331c6cbbeb36ef281a88de83
https://doi.org/10.1016/j.dmpk.2018.09.119
https://doi.org/10.1016/j.dmpk.2018.09.119
