Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Richard George Khoury"'
Autor:
Kenneth D. Rice, Neel Kumar Anand, Moon Hwan Kim, Jason Jevious Parks, Tsze H. Tsang, Donna T. Le, Larisa Dubenko, Erick Wang Co, Steven Charles Defina, Joerg Bussenius, Lynne Canne-Bannen, David J. Matthews, John M. Nuss, Stefan Engst, Simona Costanzo, Richard George Khoury, A. Douglas Laird, Diva Sze-Ming Chan, Wei Xu, Owen Joseph Bowles, Maurizio Franzini, Vasu Jammalamadaka, Ping Huang, Amy Lew Tsuhako, Yong Wang, David W. Markby, Baili Chen, Morrison B. Mac, Rhett Ronald Klein, Nicole Miller, Charles M. Blazey
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:2693-2697
Activation of the PI3K/Akt/mTOR kinase pathway is frequently associated with human cancer. Selective inhibition of p70S6Kinase, which is the last kinase in the PI3K pathway, is not sufficient for strong tumor growth inhibition and can lead to activat
Autor:
Kenneth D. Rice, Yong Wang, Lynne Canne Bannen, Morrison B. Mac, Vasu Jammalamadaka, Simona Costanzo, Maurizio Franzini, Erick Wang Co, Nicole Miller, Larisa Dubenko, Steven Charles Defina, Joerg Bussenius, Neel Kumar Anand, Douglas Laird, David J. Matthews, John M. Nuss, Jason Jevious Parks, Amy Lew Tsuhako, Rhett Ronald Klein, Donna T. Le, Tsze H. Tsang, Baili Chen, Charles M. Blazey, Moon Hwan Kim, David W. Markby, Richard George Khoury, Wei Xu, Diva Sze-Ming Chan, Owen Joseph Bowles, Stefan Engst, Ping Huang
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(6)
The 70-kDa ribosomal protein S6 kinase (p70S6K) is part of the PI3K/AKT/mTOR pathway and has been implicated in cancer. High throughput screening versus p70S6K led to the identification of aminopyrimidine 3a as active inhibitor. Lead optimization of