Zobrazeno 1 - 10
of 382
pro vyhledávání: '"Richard G. Spencer"'
Autor:
Stephen G. Gonsalves, Leorey N. Saligan, Christopher M. Bergeron, Philip R. Lee, Kenneth W. Fishbein, Richard G. Spencer, Marta Zampino, Xinyi Sun, Jennifer Yeong-Shin Sheng, Vered Stearns, Michael Carducci, Luigi Ferrucci, Nada Lukkahatai
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Physical impairments following cancer treatment have been linked with the toxic effects of these treatments on muscle mass and strength, through their deleterious effects on skeletal muscle mitochondrial oxidative capacity. Accordingly, we d
Externí odkaz:
https://doaj.org/article/9a93988e21354dae911d216638a56ee3
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)
Abstract We present a new regularization method for the solution of the Fredholm integral equation (FIE) of the first kind, in which we incorporate solutions corresponding to a range of Tikhonov regularizers into the end result. This method identifie
Externí odkaz:
https://doaj.org/article/8aff5d711f3c477db39785ce88612d47
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)
Abstract Analysis of multiexponential decay has remained a topic of active research for over 200 years. This attests to the widespread importance of this problem and to the profound difficulties in characterizing the underlying monoexponential decays
Externí odkaz:
https://doaj.org/article/eb52ad549e6043ce877e2744c7b95880
Autor:
Curtis Triebswetter, Matthew Kiely, Nikkita Khattar, Luigi Ferrucci, Susan M. Resnick, Richard G. Spencer, Mustapha Bouhrara
Publikováno v:
NeuroImage, Vol 251, Iss , Pp 118988- (2022)
Mounting evidence indicates that myelin breakdown may represent an early phenomenon in neurodegeneration, including Alzheimer's disease (AD). Understanding the factors influencing myelin synthesis and breakdown will be essential for the development a
Externí odkaz:
https://doaj.org/article/9447a961def34fde814e39974d5941f1
Autor:
Matthew Kiely, Curtis Triebswetter, Luis E. Cortina, Zhaoyuan Gong, Maryam H. Alsameen, Richard G. Spencer, Mustapha Bouhrara
Publikováno v:
NeuroImage, Vol 247, Iss , Pp 118727- (2022)
White matter (WM) microstructural properties change across the adult lifespan and with neuronal diseases. Understanding microstructural changes due to aging is paramount to distinguish them from neuropathological changes. Conducted on a large cohort
Externí odkaz:
https://doaj.org/article/362fa2e0c74d4dd2bdff893edc670afe
Autor:
Nikkita Khattar, Curtis Triebswetter, Matthew Kiely, Luigi Ferrucci, Susan M. Resnick, Richard G. Spencer, Mustapha Bouhrara
Publikováno v:
NeuroImage, Vol 239, Iss , Pp 118267- (2021)
Myelin loss and iron accumulation are cardinal features of aging and various neurodegenerative diseases. Oligodendrocytes incorporate iron as a metabolic substrate for myelin synthesis and maintenance. An emerging hypothesis in Alzheimer's disease re
Externí odkaz:
https://doaj.org/article/88609eb71426405a9b62c1dd670a622c
Autor:
Nicholas A. Brennan, Kenneth W. Fishbein, David A. Reiter, Luigi Ferrucci, Richard G. Spencer
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Skeletal muscle density, as determined by computed tomography (CT), has been shown to decline with age, resulting in increased frailty and morbidity. However, the mechanism underlying this decrease in muscle density remains elusive. We sought to inve
Externí odkaz:
https://doaj.org/article/a50a23e3472f4c129fd24d35b070cf76
Autor:
Michael A Petr, Irene Alfaras, Melissa Krawcyzk, Woei-Nan Bair, Sarah J Mitchell, Christopher H Morrell, Stephanie A Studenski, Nathan L Price, Kenneth W Fishbein, Richard G Spencer, Morten Scheibye-Knudsen, Edward G Lakatta, Luigi Ferrucci, Miguel A Aon, Michel Bernier, Rafael de Cabo
Publikováno v:
eLife, Vol 10 (2021)
Aging is associated with distinct phenotypical, physiological, and functional changes, leading to disease and death. The progression of aging-related traits varies widely among individuals, influenced by their environment, lifestyle, and genetics. In
Externí odkaz:
https://doaj.org/article/835e6a3f5fb640ebb35d98290ea431ee
Publikováno v:
NeuroImage, Vol 223, Iss , Pp 117369- (2020)
Most magnetic resonance imaging (MRI) studies investigating the relationship between regional brain myelination or axonal density and aging have relied upon nonspecific methods to probe myelin and axonal content, including diffusion tensor imaging an
Externí odkaz:
https://doaj.org/article/1e429f47dd7b4d1cbbfad76a99e91e7c
Autor:
Kyle D. Meadows, Curtis L. Johnson, John M. Peloquin, Richard G. Spencer, Edward J. Vresilovic, Dawn M. Elliott
Publikováno v:
JOR Spine, Vol 3, Iss 3, Pp n/a-n/a (2020)
Abstract Noninvasive assessments of intervertebral disc health and degeneration are critical for addressing disc degeneration and low back pain. Magnetic resonance imaging (MRI) is exceptionally sensitive to tissue with high water content, and measur
Externí odkaz:
https://doaj.org/article/5d76035d8593445492bc7753c7d7bd7e