Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Richard G. Morris"'
Geometrical patterning of receptor sites controls kinetics via many-body effects in bivalent systems
Publikováno v:
Physical Review Research, Vol 4, Iss 4, p L042028 (2022)
We report on the geometrical patterning of receptor sites in bi- and multi-valent systems as a modality for controlling kinetic behaviors, in both synthetic and biological contexts, that is independent of the underlying chemistry. Exploring motifs, c
Externí odkaz:
https://doaj.org/article/a37ffabb304c4895b8868cb7540ac276
Publikováno v:
Physical Review Research, Vol 5, Iss 1, p 013093 (2023)
Population bottlenecks involve steep declines in population size as well as changes to composition; they are an important aspect of contemporary evolution, and have been implicated across a wide range of taxa. However, the precise mechanisms by which
Externí odkaz:
https://doaj.org/article/c60879c633864883af21e188e6a67f9e
Autor:
Congyu Xu, Linjie Yu, Jinxing Hou, Rosemary J. Jackson, He Wang, Chaoli Huang, Tingting Liu, Qihui Wang, Xiaochuan Zou, Richard G. Morris, Tara L. Spires-Jones, Zhongzhou Yang, Zhenyu Yin, Yun Xu, Guiquan Chen
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 11 (2017)
Decreased expression but increased activity of PDK1 has been observed in neurodegenerative disease. To study in vivo function of PDK1 in neuron survival during cortical development, we generate forebrain-specific PDK1 conditional knockout (cKO) mice.
Externí odkaz:
https://doaj.org/article/fa20350283234f61ba26a2251002152c
Autor:
Sophie Hertel, Richard E Spinney, Stephanie Y Xu, Thomas E Ouldridge, Richard G Morris, Lawrence K Lee
Publikováno v:
Nucleic Acids Research. 50:7829-7841
The kinetics of DNA hybridization are fundamental to biological processes and DNA-based technologies. However, the precise physical mechanisms that determine why different DNA sequences hybridize at different rates are not well understood. Secondary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32db29cc81b8e6c535e553a9293220b2
https://doi.org/10.1093/nar/gkac590
https://doi.org/10.1093/nar/gkac590
Rethinking Population Bottlenecks: Intrinsic Fluctuations, Mutation and Dynamical Demographic Phases
By abruptly changing the size and composition of a population, bottlenecks can dramatically alter evolutionary trajectories. In the traditional picture, the faster a population recovers from a bottleneck, the more rapidly finite-size intrinsic fluctu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1444161d965eb0c296252d1e8f83b6ea
https://doi.org/10.1101/2022.07.28.501945
https://doi.org/10.1101/2022.07.28.501945
Autor:
Sami C. Al-Izzi, Richard G. Morris
Morphodynamic equations governing the behaviour of active nematic fluids on deformable curved surfaces are constructed in the large deformation limit. Emphasis is placed on the formulation of objective rates that account for normal deformations whils
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caf0fdcb9eac4faec3c1cf2c00fe469c
http://arxiv.org/abs/2204.13930
http://arxiv.org/abs/2204.13930
Autor:
James W. P. Brown, Rokiah G. Alford, James C. Walsh, Richard E. Spinney, Stephanie Y. Xu, Sophie Hertel, Jonathan F. Berengut, Lisanne M. Spenkelink, Antoine M. van Oijen, Till Böcking, Richard G. Morris, Lawrence K. Lee
Publikováno v:
ACS nano. 16(4)
Biomolecular complexes can form stable assemblies yet can also rapidly exchange their subunits to adapt to environmental changes. Simultaneously allowing for both stability and rapid exchange expands the functional capacity of biomolecular machines a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c73f17562be259c44f36505ed5cf595
https://pubmed.ncbi.nlm.nih.gov/35316035
https://pubmed.ncbi.nlm.nih.gov/35316035
Publikováno v:
Current Opinion in Cell Biology. 80:102154
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b4716d3bc57f8fa8a7d72552c81c61c
https://doi.org/10.1016/j.ceb.2023.102154
https://doi.org/10.1016/j.ceb.2023.102154
Autor:
Sophie Hertel, Richard E. Spinney, Stephanie Y. Xu, Thomas E. Ouldridge, Richard G. Morris, Lawrence K. Lee
The kinetics of DNA hybridisation are fundamental to biological processes and DNA-based technologies. However, the precise physical mechanisms that determine why different DNA sequences hybridise at different rates are not well understood. Secondary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a37f5fba40e873f43b13da03d98ffd1
https://doi.org/10.1101/2021.12.17.473246
https://doi.org/10.1101/2021.12.17.473246
Autor:
Isabella C Wagner, Mariët van Buuren, Marijn CW Kroes, Tjerk P Gutteling, Marieke van der Linden, Richard G Morris, Guillén Fernández
Publikováno v:
eLife, Vol 4 (2015)
Mental schemas form associative knowledge structures that can promote the encoding and consolidation of new and related information. Schemas are facilitated by a distributed system that stores components separately, presumably in the form of inter-co
Externí odkaz:
https://doaj.org/article/fee21a75dc1242669852315ee58c5ac4