Zobrazeno 1 - 10
of 515
pro vyhledávání: '"Richard G. Hegele"'
Autor:
Peter Mastrangelo, Allysia A. Chin, Stephanie Tan, Amy H. Jeon, Cameron A. Ackerley, Karen K. Siu, Jeffrey E. Lee, Richard G. Hegele
Publikováno v:
Viruses, Vol 13, Iss 2, p 261 (2021)
Nucleolin is an essential cellular receptor to human respiratory syncytial virus (RSV). Pharmacological targeting of the nucleolin RNA binding domain RBD1,2 can inhibit RSV infections in vitro and in vivo; however, the site(s) on RBD1,2 which interac
Externí odkaz:
https://doaj.org/article/36c366b2e51c4228944868cea69fc4e5
Autor:
Richard G. Hegele, Peter Mastrangelo
Publikováno v:
Viruses, Vol 5, Iss 3, Pp 873-885 (2013)
In this review we propose a partially hypothetical model of respiratory syncytial virus (RSV) binding and entry to the cell that includes the recently discovered RSV receptor nucleolin, in an attempt to stimulate further inquiry in this research area
Externí odkaz:
https://doaj.org/article/e240889fc3fc4ab0b8439c2d59e6abc4
Autor:
Peter Mastrangelo, Michael J. Norris, Wenming Duan, Edward G. Barrett, Theo J. Moraes, Richard G. Hegele
Publikováno v:
Vaccines, Vol 5, Iss 3, p 27 (2017)
Nucleolin (NCL) has been reported as a cellular receptor for the human respiratory syncytial virus (RSV). We studied the effects of re-purposing AS1411, an anti-cancer compound that binds cell surface NCL, as a possible novel strategy for RSV therapy
Externí odkaz:
https://doaj.org/article/91f7b353554f42f19163a5cae9ac3c1f
Autor:
Tobias R. Kollmann, Jeremy A. Scott, Teresa To, M.B. Azad, Theo J. Moraes, Michael Brauer, Piush J. Mandhane, Thomas Eiwegger, Allan B. Becker, Andrew J. Sandford, A. D. Befus, Frances Silverman, Catherine Laprise, Edith Chen, Richard G. Hegele, Scott J. Tebbutt, Padmaja Subbarao, W.Y.W. Lou, Anita L. Kozyrskyj, Felix Ratjen, Peter D. Paré, A.B. Becker, J.R. Brook, D. L. Holness, Meghan B. Azad, P. J. Mandhane, Joseph Macri, Sharon D. Dell, T.J. Moraes, Clare D. Ramsey, Malcolm R. Sears, M.R. Sears, Q. L. Duan, Wendy Y. W. Lou, Stuart E. Turvey, Brittany A. Matenchuk, Sukhpreet K Tamana, P. Subbarao, Sonia S. Anand, A.L. Kozyrskyj, Michael M Cyr, S.E. Turvey, Hartmut Grasemann, James A. Scott, Timothy K. Takaro, Perry Hystad, Gregory E. Miller, Kent T. HayGlass, Judah A. Denburg, Denise Daley, Elinor Simons, Diana L. Lefebvre, Michael S. Kobor
Publikováno v:
Sleep Medicine. 59:24-32
Rationale Sleep duration is critical to growth, learning, and immune function development in infancy. Strategies to ensure that national recommendations for sleep duration in infants are met require knowledge of perinatal factors that affect infant s
Autor:
Vasilija Macek, Azzeddine Dakhama, James C Hogg, Francis HY Green, Bruce K Rubin, Richard G Hegele
Publikováno v:
Canadian Respiratory Journal, Vol 6, Iss 1, Pp 37-43 (1999)
BACKGROUND: There is indirect evidence implicating viral respiratory tract infections in the pathogenesis of fatal asthma. However, it is unknown whether viruses are present within the lower respiratory tract in fatal asthma.
Externí odkaz:
https://doaj.org/article/7718b1d1643e4c939e64f2a53d2b1259
Autor:
Patricia Goggin, Jean-Claude Pache, Christoph Brochhausen, Alison Lupton, Robert A. Hirst, Zuzanna Bukowy-Bieryllo, Andreia Pinto, Karen Mackenney, Margaret W. Leigh, Amelia Shoemark, Paul Griffin, Panayotis Yiallouros, Maria Margherita De Santi, Finn P. Reinholt, Richard G. Hegele, Josep Schroeder, Mieke Boon, Estelle Escudier, Heymut Omran
Publikováno v:
European Respiratory Journal
European Respiratory Journal, 2020, 55 (4), pp.1900725. ⟨10.1183/13993003.00725-2019⟩
European Respiratory Journal (2020)
European Respiratory Journal, 2020, 55 (4), pp.1900725. ⟨10.1183/13993003.00725-2019⟩
European Respiratory Journal (2020)
Primary ciliary dyskinesia (PCD) is a heterogeneous genetic condition. European and North American diagnostic guidelines recommend transmission electron microscopy (TEM) as one of a combination of tests to confirm a diagnosis. However, there is no de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::486b3213133398a6aa91aeaa9857ed51
https://www.hal.inserm.fr/inserm-03791167
https://www.hal.inserm.fr/inserm-03791167
Autor:
Alexandra Albulescu, Yasaman Mahdaviyeh, Jasmine Kang, Sharon D. Dell, Hong Ouyang, Zhen Liu, Quynh P. H. Nguyen, Qingxu Guan, Theo J. Moraes, Lauren Erdman, Anna Goldenberg, Vito Mennella, Richard G. Hegele
Publikováno v:
Science Translational Medicine. 12
Airway clearance of pathogens and particulates relies on motile cilia. Impaired cilia motility can lead to reduction in lung function, lung transplant, or death in some cases. More than 50 proteins regulating cilia motility are linked to primary cili
Autor:
Jean-Claude Pache, Heymut Omran, Amelia Shoemark, Karen Mackenney, Finn P. Reinholt, Estelle Escudier, Zuzanna Bukowy-Bieryllo, Paul Griffin, Andreia Pinto, Margaret W. Leigh, Robert A. Hirst, Panyiotis Yiallouros, Mieke Boon, Maria Margherita De Santi, Christoph Brochhausen, Andrew Rutman, Richard G. Hegele, Alison Lupton, Patricia Goggin
Publikováno v:
Paediatric respiratory epidemiology.
Primary Ciliary Dyskinesia (PCD) is a heterogeneous genetic condition. European and North American diagnostic guidelines recommend transmission electron microscopy as one of a combination of tests to confirm a diagnosis. However, there is no definiti
Autor:
Richard G. Hegele, A. D. Befus, James A. Scott, Rishma Chooniedass, Jeffrey R. Brook, Tobias R. Kollmann, A.B. Becker, Theo J. Moraes, P. J. Mandhane, J D Duncan, Padmaja Subbarao, Kent T. HayGlass, Malcolm R. Sears, Diana L. Lefebvre, Joseph Macri, Child Study Investigators, Stuart E. Turvey, Timothy K. Takaro, Judah A. Denburg
Publikováno v:
Paediatric and Perinatal Epidemiology. 29:84-92
Background It is hypothesised that complex interactions between genetic and environmental factors give rise to allergy and asthma in childhood. The Canadian Healthy Infant Longitudinal Development (CHILD) study was designed to explore these factors.
Autor:
Edward G. Barrett, Richard G. Hegele, Peter Mastrangelo, Michael J Norris, Wenming Duan, Theo J. Moraes
Publikováno v:
Vaccines, Vol 5, Iss 3, p 27 (2017)
Vaccines; Volume 5; Issue 3; Pages: 27
Vaccines
Vaccines; Volume 5; Issue 3; Pages: 27
Vaccines
Nucleolin (NCL) has been reported as a cellular receptor for the human respiratory syncytial virus (RSV). We studied the effects of re-purposing AS1411, an anti-cancer compound that binds cell surface NCL, as a possible novel strategy for RSV therapy