Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Richard G. Hansford"'
Autor:
R. Michael Anson, Richard G. Hansford
Publikováno v:
Aging Cell. 3:29-34
Summary Virtually every model of mitochondrial involvement in aging shares the underlying proposition that mitochondrial dysfunction will accelerate the rate of aging. Caenorhabditis elegans is a post-mitotic organism with limited capacity for replac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::119e2a85ff107094d4fb18e9ba8d1c78
https://doi.org/10.1111/j.1474-9728.2003.00077.x
https://doi.org/10.1111/j.1474-9728.2003.00077.x
Autor:
George S. Roth, Richard G. Spencer, Richard G. Hansford, Alena Horská, Larry J. Brant, Donald K. Ingram
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 276:E766-E773
We evaluated the hypothesis that long-term caloric restriction and exercise would have beneficial effects on muscle bioenergetics and performance in the rat. By themselves, each of these interventions is known to increase longevity, and bioenergetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b4feb1e1ee8297204afc79163c401c8
https://doi.org/10.1152/ajpendo.1999.276.4.e766
https://doi.org/10.1152/ajpendo.1999.276.4.e766
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 276:H149-H158
Aberrations in cell Ca2+homeostasis have been known to parallel both changes in membrane lipid composition and aging. Previous work has shown that the lowered efficiency of work performance, which occurs in isolated hearts from rats fed a diet rich i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9189caa7fc31f8b797e196da108cf3c0
https://doi.org/10.1152/ajpheart.1999.276.1.h149
https://doi.org/10.1152/ajpheart.1999.276.1.h149
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1365:522-530
We studied the interaction between energy metabolism and mitochondrial biogenesis during myogenesis in C2C12 myoblasts. Metabolic rate was nearly constant throughout differentiation, although there was a shift in the relative importance of glycolytic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a498daef4b8a588a7238a258e0284af
https://doi.org/10.1016/s0005-2728(98)00105-4
https://doi.org/10.1016/s0005-2728(98)00105-4
Autor:
Colette M. J. Ap Rhys, Edgar K. Hudson, Richard G. Hansford, Vilhelm A. Bohr, Grigory L. Dianov, Deborah L. Croteau
Publikováno v:
Journal of Biological Chemistry. 272:27338-27344
Reactive oxygen species have been shown to generate mutagenic lesions in DNA. One of the most abundant lesions in both nuclear and mitochondrial DNA is 7,8-dihydro-8-oxoguanine (8-oxoG). We report here the partial purification and characterization of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::446b3e694c6810f354e833cc3314c8d8
https://doi.org/10.1074/jbc.272.43.27338
https://doi.org/10.1074/jbc.272.43.27338
Publikováno v:
Journal of Bioenergetics and Biomembranes. 29:89-95
We have examined the substrate specificity and inhibitor sensitivity of H2O2 formation by rat heart mitochondria. Active H2O2 production requires both a high fractional reduction of Complex I (indexed by NADH/NAD+ + NADH ratio) and a high membrane po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5f59c6e2c50e7d8f5e1a59893915932
https://doi.org/10.1023/a:1022420007908
https://doi.org/10.1023/a:1022420007908
Autor:
Michio Tamatani, Irina Kudryashova, Charles R. Filburn, Richard G. Hansford, Wade Edris, Barbara A. Hogue
Publikováno v:
Mechanisms of Ageing and Development. 87:35-46
Deletions in human mitochondrial DNA cause various mitochondrial myopathies and increase markedly with age in highly oxidative tissues, but exhibit a differential distribution in the brain. In order to determine whether a similar pattern occurs in ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67d6ce11930281acacb7d7bd24ad77c2
https://doi.org/10.1016/0047-6374(96)01696-x
https://doi.org/10.1016/0047-6374(96)01696-x
Publikováno v:
Anesthesiology. 80:372-382
Background: Cardiac cellular Ca metaboliam is central to the control of the inotropic state of the heart and is altered in various ways by the volatile anesthetics halothane, enflurane and isoflurane. Specifically, differences among the agents regard
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3c87996b3be117533a2522275fe4240
https://doi.org/10.1097/00000542-199402000-00017
https://doi.org/10.1097/00000542-199402000-00017
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 264:H2188-H2197
The fraction of total pyruvate dehydrogenase in the active, dephosphorylated form is much lower in the glucose-perfused isolated hearts of two myopathic strains of Syrian hamster (BIO 14.6 and TO-2) than in the hearts of healthy control animals (F1B)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f9c2ea248556a6d1732b69197714de4
https://doi.org/10.1152/ajpheart.1993.264.6.h2188
https://doi.org/10.1152/ajpheart.1993.264.6.h2188
Autor:
O. Y. Chung, Maurizio C. Capogrossi, Richard G. Hansford, Michael D. Stern, Barbara A. Hogue, H. S. Silverman, Paul S. Blank, Edward G. Lakatta
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 263:H276-H284
This study examines the use of carboxy-seminaphthorhodafluor-1 (C-SNARF-1) as an indicator of cytosolic pH in isolated rat cardiac myocytes. The emission spectrum of C-SNARF-1 when excited at 530 nm contains two well-separated peaks at approximately
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::666dca8a018c5a6835537c4b45c95d2e
https://doi.org/10.1152/ajpheart.1992.263.1.h276
https://doi.org/10.1152/ajpheart.1992.263.1.h276