Výsledky vyhledávání - "Richard G. Dulina"

3-Azido-3-deoxy-glycopyranoside derivatives as scaffolds for the synthesis of carbohydrate-Based universal pharmacophore mapping libraries

Autor: Muthoni G. Kamau, Chunguang Wang, Rakesh K. Jain, Huiming Wang, Michael J. Sofia, Richard G. Dulina, Robert Ippolito, David Gange, Jan A. Anderson

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 13:2185-2189

The regiospecific syntheses of six monosaccharide scaffolds, 1 – 6 , containing a carboxylic acid, an azido and a free hydroxyl group were accomplished through the utilization of a key intermediate, namely, methyl 3-azido-3-deoxy-β- d -glucopyrano

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7110adb51866809082e64164c5cc4e06
https://doi.org/10.1016/s0960-894x(03)00384-6

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Discovery of Novel Disaccharide Antibacterial Agents Using a Combinatorial Library Approach

Publikováno v: Journal of Medicinal Chemistry. 42:3193-3198

The increase in bacterial resistance to conventional chemotherapy has resulted in a resurgent interest in the discovery and development of antibacterial agents.1-4 The search for novel antibiotics active against resistant phenotypes is increasingly f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae445443dbe326863e7cdf3e76e733bc
https://doi.org/10.1021/jm990212a

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Expeditious route to F unit building block of moenomycin A

Autor: Michael J. Sofia, Manuka Ghosh, Richard G. Dulina, Ramesh Kakarla, Jan A. Anderson

Publikováno v: Tetrahedron Letters. 40:5-8

Synthesis of the versatile F sugar unit building block of moenomycin A, Phenyl 2-O-levulinoyl-4-C-methyl-1-thio-β-D-glucopyranosiduronic acid is described starting from phenyl 1-thio-β-D-galactopyranoside. The key synthetic steps included: (I) Regi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1fd4307db222e3f8278a890521a8a8d4
https://doi.org/10.1016/s0040-4039(98)80003-8

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The efficient synthesis of a bis-glycosylated steroid drug transport reagent: Methyl 3-β-amino-7α, 12α-di(1′α-glucosyl)-5β-cholate (TC002)

Autor: Natan A. Kogan, Y. W. Hui, Richard G. Dulina, Michael J. Sofia, Dashan Liu, Thomas Wagler, Ramesh Kakarla, Anna Chen, Nicole T. Hatzenbuhler

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 7:2251-2254

The drug transport reagent, methyl 3-β-amino-7α, 12α-di(1′α-glucosyl)-5β-cholate (TC002) 1 was prepared in 15% overall yield from pentaacetyl glucose and methyl cholate. Pentaacetyl glucose was converted to glucosyl sulfoxide 2 in 56% overall

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2cd723ce5249cbf5a6b2d85eaa1979f1
https://doi.org/10.1016/s0960-894x(97)00410-1

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