Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Richard G. Conway"'
Autor:
Michelle M. Rodriguez, Carl Overshiner, J. David Leander, Xia Li, Denise Morrow, Richard G. Conway, David L. Nelson, Karin Briner, Jeffrey M. Witkin
Publikováno v:
Frontiers in Psychiatry, Vol 8 (2017)
Selective serotonin reuptake inhibitors (SSRIs) are the only effective pharmacological treatments for obsessive–compulsive disorder (OCD). Nonetheless, their generally limited efficacy, side-effects, and delayed onset of action require improved med
Externí odkaz:
https://doaj.org/article/098346da55bb4d9baa40299e4e91562c
Autor:
Keith G Avin, Neal X Chen, Jason M Organ, Chad Zarse, Kalisha O'Neill, Richard G Conway, Robert J Konrad, Robert L Bacallao, Matthew R Allen, Sharon M Moe
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0159411 (2016)
Skeletal muscle atrophy and impaired muscle function are associated with lower health-related quality of life, and greater disability and mortality risk in those with chronic kidney disease (CKD). However, the pathogenesis of skeletal dysfunction in
Externí odkaz:
https://doaj.org/article/9fab6b85c9054d00800570163fd79134
Autor:
Ian Travers Crosby, Alan D. Robertson, Celine Valant, Arthur Christopoulos, Richard G. Conway, Benvenuto Capuano
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:2560-2564
A series of substituted 4-arylpiperidines and a smaller family of 4-aryl-1,2,3,6-tetrahydropyridines were synthesized and their biological activity at the 5-HT(2C) receptor studied to determine whether either series showed noteworthy agonist activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b4bed0f0a65f133dd0caa6dc4f6ad1b
https://doi.org/10.1016/j.bmcl.2012.01.122
https://doi.org/10.1016/j.bmcl.2012.01.122
Autor:
Terrance J. Magoc, Richard G. Conway, Douglas H. Steinman, Daisy Pireh, Michael L. Curtin, James H. Holms, James B. Summers, H. Robin Heyman, Steven K. Davidsen, Paul Tapang, Daniel H. Albert, George M. Carrera, George S. Sheppard, Rhein Da
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:2913-2918
3-(3-Pyridinyl)-7-(indol-3-ylcarbonyl)-1H-3H-pyrrolo[1,2-c]thiazoles represent a class of potent, orally active PAF antagonists; however, the lead compounds in this series suffered from a lack of aqueous solubility. To overcome this limitation, a num
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::56f13f4772af4862d22906eb73903181
https://doi.org/10.1016/0960-894x(95)00511-q
https://doi.org/10.1016/0960-894x(95)00511-q
Autor:
Terrance J. Magoc, Daisy Pireh, George S. Sheppard, H. Robin Heyman, Richard G. Conway, Douglas H. Steinman, James H. Holms, Steven K. Davidsen, Rhein Da, Gongjin Luo, George M. Carrera, Nichael L. Curtin, James B. Summers, Paul Tapang, Daniel H. Albert
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:2903-2908
3-(3-Pyridinyl)-7-(indol-3-ylcarbonyl)-1 H -3 H -pyrrolo[1,2-c]thiazoles represent a new class of platelet activating factor antagonists. This series was discovered by combining the indole portion of a previous thiazolidine series with the known 3-py
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::588d2ed92275742c29377dbac13be3ca
https://doi.org/10.1016/0960-894x(95)00509-r
https://doi.org/10.1016/0960-894x(95)00509-r
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:1097-1102
Conformationally constrained analogues of platelet activating factor incorporating various combinations of a lipophile and a pyridine-like heterocycle via hydrogen bond acceptors such as ether and/or carbamate linked to a suitable core group such as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3eaace8cf1c6aea5d2c78cb9651cdac8
https://doi.org/10.1016/0960-894x(95)00174-r
https://doi.org/10.1016/0960-894x(95)00174-r
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:1091-1096
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f7f08065dfb0325995fe77025dd134b4
https://doi.org/10.1016/0960-894x(95)00173-q
https://doi.org/10.1016/0960-894x(95)00173-q
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 3:2729-2732
PAF antagonist 1 is susceptible to thiazolidine ring fragmentation in vitro and in vivo. The search for a more stable compound prompted the synthesis of a series of bicyclic analogs. Three classes of bicyclic thiazolidines (2: X = 0, CH2, NCH3) were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::72fa5fa0618a29eaac4c246fdb6415a4
https://doi.org/10.1016/s0960-894x(01)80753-8
https://doi.org/10.1016/s0960-894x(01)80753-8
Autor:
G. M. Jun. Carrera, T. J. Magoc, William C. Calhoun, Daisy Pireh, H. R. Heyman, Rhein Da, S. K. Davidsen, Paul D. May, Richard G. Conway, James B. Summers, Denise E. Guinn, James G. Phillips, George W. Carter, G. S. Sheppard, Daniel H. Albert, D. H. Steinman, M. G. Bures
Publikováno v:
ChemInform. 25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f9da27a79fd4362f079e8a53d75ae9d0
https://doi.org/10.1002/chin.199450141
https://doi.org/10.1002/chin.199450141
Autor:
Daisy Pireh, James H. Holms, Daniel H. Albert, T. J. Magoc, G. M. Jun. Carrera, G. S. Sheppard, D. H. Steinman, Rhein Da, H. R. Heyman, Paul Tapang, S. K. Davidsen, Richard G. Conway, James B. Summers, Michael L. Curtin
Publikováno v:
ChemInform. 27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::28b1a02626b4f7b7ba3e0064000ceb8c
https://doi.org/10.1002/chin.199614129
https://doi.org/10.1002/chin.199614129