Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Richard G. Buckholz"'
Autor:
Tony Y. Wang, Chiara Piubelli, Lee T. Schaller, Pierette Banker, Stefano Tacconi, Paula Selley, Todd W. Shearer, Robert A. Reid, Federico Faggioni, Daniel J. Price, Richard F. Cox, Shawn P. Williams, David H. Drewry, Michela Tessari, Richard G. Buckholz, Patrick R. Maloney, Paul R. Reid, Brian D. Thompson, Xi Liang, Jeffery L. Smith, Octerloney B. McDonald, Ilaria Sartori
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:1958-1963
Hypothalamic CAMKK2 represents a potential mechanism for chemically affecting satiety and promoting weight loss in clinically obese patients. Single-digit nanomolar inhibitors of CAMKK2 were identified in three related ATP-competitive series. Limited
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77ef3d3a14b6690b03d61d51517e7124
https://doi.org/10.1016/j.bmcl.2018.03.034
https://doi.org/10.1016/j.bmcl.2018.03.034
Autor:
Marie A. Iannone, Lisa M. Leesnitzer, Andrew N. Billin, Timothy M. Willson, Kenneth H. Pearce, Robert T. Nolte, William J. Hoekstra, Sumin M. Zhao, Richard G. Buckholz, Millard H. Lambert, Barry G. Shearer, Cobb Jeffrey Edmond, Ryan P. Trump
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:3916-3920
PPARgamma-activating thiazolidinediones and carboxylic acids such as farglitazar exert their anti-diabetic effects in part in PPARgamma rich adipose. Both pro- and anti-adipogenic PPARgamma ligands promote glucose and lipid lowering in animal models
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19bc303ea054044b6e214de85d42ee90
https://doi.org/10.1016/j.bmcl.2007.04.111
https://doi.org/10.1016/j.bmcl.2007.04.111
Autor:
James E. Weiel, Walter S. Dallas, Emily A. Hull-Ryde, Mary E. Lancaster, James M. Lenhard, Richard G. Buckholz, Mark A. Paulik
Publikováno v:
Pharmaceutical Research. 15:944-949
Purpose. Although the effects of thermogenic agents in cell culture can be measured by direct microcalorimetry, only a few samples can be analyzed over several hours. In this report, we describe a robust non-invasive technique to measure real-time th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71e9e8f0dea5aa3b898b1b3e04424162
https://doi.org/10.1023/a:1011993019385
https://doi.org/10.1023/a:1011993019385
Autor:
Cristin M. Galardi, John T. Moore, Stephen M. Hyatt, Richard G. Buckholz, Timothy M. Willson, William J. Zuercher, Susan L. Merrihew, Nino Campobasso, Paul Reid, Eugene L. Stewart, Jon L. Collins, Thomas B. Stanley, Paul Kenneth Spearing, Robert T. Gampe, Jeffrey Alan Oplinger
Publikováno v:
Journal of medicinal chemistry. 53(8)
Tertiary sulfonamides were identified in a HTS as dual liver X receptor (LXR, NR1H2, and NR1H3) ligands, and the binding affinity of the series was increased through iterative analogue synthesis. A ligand-bound cocrystal structure was determined whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f032cf6e0ab068ebc9ed2ef32dde507
https://pubmed.ncbi.nlm.nih.gov/20345102
https://pubmed.ncbi.nlm.nih.gov/20345102
Publikováno v:
Yeast. 7:913-923
The allantoinase (DAL1) gene from Saccharomyces cerevisiae has been cloned, sequenced, and found to encode a 472 amino acid protein with a Mr of 52,028. DAL1 is expressed in an inducer-independent manner in strain M970 (sigma 1278b genetic background
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b258c4d68fb38040e06fc43e0bd95bd
https://doi.org/10.1002/yea.320070903
https://doi.org/10.1002/yea.320070903
Publikováno v:
BioTechniques. 21(2)
We have altered the antibiotic resistance of the reporter plasmids and the pJG4-5 activation-domain and pEG202 DNA binding-domain plasmids used in the Brent interaction trap/two-hybrid system. These plasmids were each previously ampicillin-resistant,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15fdf96031902963c3e11047abf3b3b4
https://pubmed.ncbi.nlm.nih.gov/8862810
https://pubmed.ncbi.nlm.nih.gov/8862810
Autor:
Richard G. Buckholz
Publikováno v:
Current opinion in biotechnology. 4(5)
Significant advances have been made over the past year in our understanding of some of the critical parameters affecting high-level production of heterologous proteins in yeast. Recent studies of plasmid stability, promoter strength and secretion eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e72e5855a8f3bd894a1c3066774651c
https://pubmed.ncbi.nlm.nih.gov/7764203
https://pubmed.ncbi.nlm.nih.gov/7764203
Autor:
Bruce G. Adams, Richard G. Buckholz
Publikováno v:
Moleculargeneral genetics : MGG. 182(1)
The induction of alpha-galactosidase of Saccharomyces cerevisiae was investigated. We have demonstrated the existence of inducible internal and external alpha-galactosidase activities and have studied the relationship between the two alpha-galactosid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::022986296fddbab6722829c1439506e0
https://pubmed.ncbi.nlm.nih.gov/6267434
https://pubmed.ncbi.nlm.nih.gov/6267434