Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Richard G. A. Faragher"'
Publikováno v:
PLoS ONE, Vol 19, Iss 8 (2024)
Externí odkaz:
https://doaj.org/article/cb8788f0e75c4ae2af5c545781a247ac
Autor:
Eva Latorre, Vishal C. Birar, Angela N. Sheerin, J. Charles C. Jeynes, Amy Hooper, Helen R. Dawe, David Melzer, Lynne S. Cox, Richard G. A. Faragher, Elizabeth L. Ostler, Lorna W. Harries
Publikováno v:
BMC Cell Biology, Vol 18, Iss 1, Pp 1-15 (2017)
Abstract Background Altered expression of mRNA splicing factors occurs with ageing in vivo and is thought to be an ageing mechanism. The accumulation of senescent cells also occurs in vivo with advancing age and causes much degenerative age-related p
Externí odkaz:
https://doaj.org/article/717f49a517e94b39be55597aba23e861
Publikováno v:
Sub-cellular biochemistry. 102
Cellular senescence is a permanent state of growth arrest coupled with profound changes in phenotype that can be triggered by multiple extrinsic or intrinsic stimuli. Senescence is a process-level example of the evolution of ageing mechanisms through
Publikováno v:
Biochemistry and Cell Biology of Ageing: Part III Biomedical Science ISBN: 9783031214097
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e17166a6a8a72ae298ccf41089ab49de
https://doi.org/10.1007/978-3-031-21410-3_8
https://doi.org/10.1007/978-3-031-21410-3_8
Publikováno v:
Biogerontology. 21:817-826
Resveratrol alters the cytokinetics of mammalian cell populations in a dose dependent manner. Concentrations above 25-50 µM typically trigger growth arrest, senescence and/or apoptosis in multiple different cell types. In contrast, concentrations be
Autor:
Richard G. A. Faragher
Publikováno v:
Frontiers in Aging. 2
Cellular senescence, the irreversible growth arrest of cells from conditional renewal populations combined with a radical shift in their phenotype, is a hallmark of ageing in some mammalian species. In the light of this, interest in the detection of
Autor:
Andrew Overall, Richard G. A. Faragher
Publikováno v:
Heredity
Mutation accumulation is one of the major genetic theories of ageing and predicts that the frequencies of deleterious alleles that are neutral to selection until post-reproductive years are influenced by random genetic drift. The effective population
Autor:
J. Charles C. Jeynes, David Melzer, Amy Hooper, Helen R. Dawe, Eva Latorre, Lynne S. Cox, Vishal C. Birar, Richard G. A. Faragher, Elizabeth L. Ostler, Angela Sheerin, Lorna W. Harries
Publikováno v:
Zaguán: Repositorio Digital de la Universidad de Zaragoza
Universidad de Zaragoza
Zaguán. Repositorio Digital de la Universidad de Zaragoza
instname
BMC Cell Biology
BMC Cell Biology, Vol 18, Iss 1, Pp 1-15 (2017)
Universidad de Zaragoza
Zaguán. Repositorio Digital de la Universidad de Zaragoza
instname
BMC Cell Biology
BMC Cell Biology, Vol 18, Iss 1, Pp 1-15 (2017)
Background Altered expression of mRNA splicing factors occurs with ageing in vivo and is thought to be an ageing mechanism. The accumulation of senescent cells also occurs in vivo with advancing age and causes much degenerative age-related pathology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8aceecdf8d4045ea3a0fb1c94c888eb
http://zaguan.unizar.es/record/89885
http://zaguan.unizar.es/record/89885
Autor:
Wei Wu He, Brenna Osborne, Dario Riccardo Valenzano, Lene Juel Rasmussen, Rafael de Cabo, Dudley W. Lamming, Jim Mellon, Evandro Fei Fang, Marсo Demaria, Aubrey de Grey, Andrey A. Parkhitko, Lei Zhang, Sergey Young, Nanna MacAulay, Vera Gorbunova, Martin Borch Jensen, Jonas T. Treebak, Alexey Moskalev, Judith Campisi, Anais Franco-Romero, Nuno Raimundo, Collin Y. Ewald, Morten Scheibye-Knudsen, Riekelt H. Houtkooper, Majken K. Jensen, Luigi Ferrucci, Kai Fu Lee, Jan H.J. Hoeijmakers, Eva Hoffmann, Carolina Reis, Søren Brunak, Thomas A. Rando, David A. Sinclair, David J. Glass, Daniela Bakula, Adam Freund, Pam R. Taub, Brian K. Kennedy, Yousin Suh, Moustapha Kassem, Kotb Abdelmohsen, Polina Mamoshina, Björn Schumacher, Debra Toiber, Ana Maria Cuervo, Gerard Karsenty, Peter L.J. de Keizer, Laura J. Niedernhofer, Ieva Bagdonaite, Christian G. Riedel, Steve Horvath, Richard G. A. Faragher, Carlos G. Silva-García, Vadim N. Gladyshev, Alice E. Kane, Anastasia Georgievskaya, Eric Verdin, Marte Molenaars, Nir Barzilai, Filipe Cabreiro, Heidi H. Pak, Pénélope Andreux, Garik Mkrtchyan, Alex Zhavoronkov, Andreas Mund, Jan Vijg
Publikováno v:
Aging (Albany NY)
Mkrtchyan, G V, Abdelmohsen, K, Andreux, P, Bagdonaite, I, Barzilai, N, Brunak, S, Cabreiro, F, de Cabo, R, Campisi, J, Cuervo, A M, Demaria, M, Ewald, C Y, Fang, E F, Faragher, R, Ferrucci, L, Freund, A, Silva-García, C G, Georgievskaya, A, Gladyshev, V N, Glass, D J, Gorbunova, V, de Grey, A, He, W-W, Hoeijmakers, J, Hoffmann, E, Horvath, S, Houtkooper, R H, Jensen, M K, Jensen, M B, Kane, A, Kassem, M, de Keizer, P, Kennedy, B, Karsenty, G, Lamming, D W, Lee, K-F, MacAulay, N, Mamoshina, P, Mellon, J, Molenaars, M, Moskalev, A, Mund, A, Niedernhofer, L, Osborne, B, Pak, H H, Parkhitko, A, Raimundo, N, Rando, T A, Rasmussen, L J, Reis, C, Riedel, C G, Franco-Romero, A, Schumacher, B, Sinclair, D A, Suh, Y, Taub, P R, Toiber, D, Treebak, J T, Valenzano, D R, Verdin, E, Vijg, J, Young, S, Zhang, L, Bakula, D, Zhavoronkov, A & Scheibye-Knudsen, M 2020, ' ARDD 2020 : from aging mechanisms to interventions ', Aging, vol. 12, no. 24, pp. 24484-24503 . https://doi.org/10.18632/aging.202454
Aging, 12(24), 24486-24503. Impact Journals LLC
Aging, vol 12, iss 24
Aging, 12 (24)
Aging, 12(24), 24486-24503. US Administration on Aging
Mkrtchyan, G V, Abdelmohsen, K, Andreux, P, Bagdonaite, I, Barzilai, N, Brunak, S, Cabreiro, F, de Cabo, R, Campisi, J, Cuervo, A M, Demaria, M, Ewald, C Y, Fang, E F, Faragher, R, Ferrucci, L, Freund, A, Silva-García, C G, Georgievskaya, A, Gladyshev, V N, Glass, D J, Gorbunova, V, de Grey, A, He, W-W, Hoeijmakers, J, Hoffmann, E, Horvath, S, Houtkooper, R H, Jensen, M K, Jensen, M B, Kane, A, Kassem, M, de Keizer, P, Kennedy, B, Karsenty, G, Lamming, D W, Lee, K-F, MacAulay, N, Mamoshina, P, Mellon, J, Molenaars, M, Moskalev, A, Mund, A, Niedernhofer, L, Osborne, B, Pak, H H, Parkhitko, A, Raimundo, N, Rando, T A, Rasmussen, L J, Reis, C, Riedel, C G, Franco-Romero, A, Schumacher, B, Sinclair, D A, Suh, Y, Taub, P R, Toiber, D, Treebak, J T, Valenzano, D R, Verdin, E, Vijg, J, Young, S, Zhang, L, Bakula, D, Zhavoronkov, A & Scheibye-Knudsen, M 2020, ' ARDD 2020 : from aging mechanisms to interventions ', Aging, vol. 12, no. 24, pp. 24484-24503 . https://doi.org/10.18632/aging.202454
Aging, 12(24), 24486-24503. Impact Journals LLC
Aging, vol 12, iss 24
Aging, 12 (24)
Aging, 12(24), 24486-24503. US Administration on Aging
Aging is emerging as a druggable target with growing interest from academia, industry and investors. New technologies such as artificial intelligence and advanced screening techniques, as well as a strong influence from the industry sector may lead t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3497e8366f86e4471317db5f9f7af5f9
Publikováno v:
The FASEB Journal. 33:1086-1097
Cellular plasticity is a key facet of cellular homeostasis requiring correct temporal and spatial patterns of alternative splicing. Splicing factors, which orchestrate this process, demonstrate age-related dysregulation of expression; they are emergi