Zobrazeno 1 - 10
of 244
pro vyhledávání: '"Richard G Spencer"'
Autor:
Michael A Petr, Irene Alfaras, Melissa Krawcyzk, Woei-Nan Bair, Sarah J Mitchell, Christopher H Morrell, Stephanie A Studenski, Nathan L Price, Kenneth W Fishbein, Richard G Spencer, Morten Scheibye-Knudsen, Edward G Lakatta, Luigi Ferrucci, Miguel A Aon, Michel Bernier, Rafael de Cabo
Publikováno v:
eLife, Vol 10 (2021)
Aging is associated with distinct phenotypical, physiological, and functional changes, leading to disease and death. The progression of aging-related traits varies widely among individuals, influenced by their environment, lifestyle, and genetics. In
Externí odkaz:
https://doaj.org/article/835e6a3f5fb640ebb35d98290ea431ee
Autor:
Luigi Ferrucci, Mustapha Bouhrara, Joseph S R Alisch, Nikkita Khattar, Richard W Kim, Abinand C Rejimon, Luis E Cortina, Wenshu Qian, Susan M Resnick, Richard G Spencer
Publikováno v:
BMJ Neurology Open, Vol 2, Iss 1 (2020)
Background Myelin loss and cerebral blood flow (CBF) decline are central features of several neurodegenerative diseases. Myelin maintenance through oligodendrocyte metabolism is an energy-demanding process, so that myelin homeostasis is particularly
Externí odkaz:
https://doaj.org/article/73145046eb164f8a843f7b44b6f2f546
Autor:
Beth G Ashinsky, Kenneth W Fishbein, Erin M Carter, Ping-Chang Lin, Nancy Pleshko, Cathleen L Raggio, Richard G Spencer
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0157891 (2016)
The purpose of this study is to evaluate the ability of quantitative magnetic resonance imaging (MRI) to discriminate between skin biopsies from individuals with osteogenesis imperfecta (OI) and skin biopsies from individuals without OI. Skin biopsie
Externí odkaz:
https://doaj.org/article/d12e28910f144e33ac47adc787e169ad
Autor:
Donnie Cameron, David A. Reiter, Fatemeh Adelnia, Ceereena Ubaida‐Mohien, Christopher M. Bergeron, Seongjin Choi, Kenneth W. Fishbein, Richard G. Spencer, Luigi Ferrucci
Publikováno v:
Aging Cell.
Autor:
Mary E Faulkner, John P Laporte, Zhaoyuan Gong, Mohammad A B S Akhonda, Curtis Triebswetter, Matthew Kiely, Elango Palchamy, Richard G Spencer, Mustapha Bouhrara
Publikováno v:
The Journals of Gerontology: Series A.
Mounting evidence indicates that abnormal gait speed predicts the progression of neurodegenerative diseases, including Alzheimer’s disease. Understanding the relationship between white matter integrity, especially myelination, and motor function is
Autor:
Zhaoyuan Gong, Murat Bilgel, Matthew Kiely, Curtis Triebswetter, Luigi Ferrucci, Susan M. Resnick, Richard G. Spencer, Mustapha Bouhrara
Publikováno v:
Alzheimer's & Dementia.
Autor:
Carla Rocha Dos Santos, Yulia N Grigorova, Ross A McDevitt, Jeffrey M Long, Defne Cezayirli, Valentina Zernetkina, Wen Wei, Mahdi Haghkar, Christopher H Morrell, Ondrej Juhasz, Edward G Lakatta, Richard G Spencer, Peter R. Rapp, Kenneth W Fishbein, Olga V Fedorova
Publikováno v:
Alzheimer's & Dementia. 18
Publikováno v:
Scientific Reports. 12
We present a new regularization method for the solution of the Fredholm integral equation (FIE) of the first kind, in which we incorporate solutions corresponding to a range of Tikhonov regularizers into the end result. This method identifies solutio
Autor:
Matthew Kiely, Curtis Triebswetter, Zhaoyuan Gong, John P. Laporte, Mary E. Faulkner, Mohammad A. B. S. Akhonda, Maryam H. Alsameen, Richard G. Spencer, Mustapha Bouhrara
Publikováno v:
Journal of Magnetic Resonance Imaging.
Cerebral tissue integrity decline and cerebral blood flow (CBF) alteration are major aspects of motor and cognitive dysfunctions and neurodegeneration. However, little is known about the association between blood flow and brain microstructural integr
Autor:
Nikkita Khattar, Mustapha Bouhrara, Luis E. Cortina, Abinand C. Rejimon, Samuel Ajamu, Richard G. Spencer, Defne Cezayirli
Publikováno v:
Aging (Albany NY)
Brainstem tissue microstructural properties change across the adult lifespan. However, studies elucidating the biological processes that govern brainstem maturation and degeneration in-vivo are lacking. In the present work, conducted on a large cohor