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pro vyhledávání: '"Richard G Cutler"'
Autor:
Richard G Cutler, Henry Rodriguez
This innovative and comprehensive reference book provides the most up-to-date information pertaining to the translational research field of oxidative stress and aging. The book focuses on understanding the molecular basis of oxidative stress and its
Autor:
Richard G. Cutler
Publikováno v:
Annals of the New York Academy of Sciences. 1055:93-135
Steadily accumulating scientific evidence supports the general importance of oxidative damage of tissue and cellular components as a primary or secondary causative factor in many different human diseases and aging processes. Our goal has been to deve
Autor:
Dean P. Jones, L P Guarante, Richard G. Cutler, Frederick Naftolin, Charles R. Cantor, Thomas W. Kensler, George M. Martin
Publikováno v:
Annals of the New York Academy of Sciences. 1055:58-63
Publikováno v:
Annals of the New York Academy of Sciences. 1055:136-158
Many of the most serious human diseases have a strong association with the steady-state level of oxidative damage in tissues. On an individual level this damage is defined as the patient's oxidative stress status (OSS). OSS is associated with many of
Autor:
George S. Roth, Jane M. Heim, Terence H. Risby, Long Jiang, Edward L. Spangler, Donald K. Ingram, Richard G. Cutler, Sigfried Stoll, Joseph M. Rifkind
Publikováno v:
Journal of Applied Physiology. 86:617-622
Breath ethane, O2consumption, and CO2 production were analyzed in 24-mo-old female Fischer 344 rats that had been fed continuously ad libitum (AL) or restricted 30% of AL level (DR) diets since 6 wk of age. Rats were placed in a glass chamber that wa
Autor:
Antonio Ayala, Richard G. Cutler
Publikováno v:
Archives of Gerontology and Geriatrics. 24:87-102
This study was undertaken to determine whether the detoxification pathways producing the least oxidative stress appear to be favored in longer-lived mammalian species. Firstly, we focused on the cytochrome P-450 monooxygenase system. Although this sy
Autor:
Edward J. Masoro, John Fogarty, David R. Sell, George S. Roth, Donald K. Ingram, Wesley A. Johnson, Karen M. Reiser, Orin B. Mock, Vincent M. Monnier, Richard G. Cutler, Mark A. Lane
Publikováno v:
Proceedings of the National Academy of Sciences. 93:485-490
A fundamental question in the basic biology of aging is whether there is a universal aging process. If indeed such a process exists, one would expect that it develops at a higher rate in short- versus long-lived species. We have quantitated pentosidi
Autor:
Antonio Ayala, Richard G. Cutler
Publikováno v:
Free Radical Biology and Medicine. 21:65-80
Alteration of cellular proteins by oxidative modification could represent an important mechanism leading to cellular dysdifferentiation and age-related diseases. There is difficulty in testing this hypothesis because of a lack of specific assays that
Autor:
Antonio Ayala, Richard G. Cutler
Publikováno v:
Free Radical Biology and Medicine. 21:551-558
Previous studies indicate that 5-hydroxy-2-amino valeric acid (HAVA) is an excellent marker of oxidized arginine and proline in purified proteins. We report here experiments testing the specificity of the HAVA assay technique using the unpurified 100