Výsledky vyhledávání - "Richard Göttlich"

Akademický článek

Bis(2,2,2 trifluoroethyl) Phosphonate as a Convenient Precursor for the Synthesis of H-Phosphonates

Autor: Jean-Marie Pohl, Fabian Stöhr, Tim Kramer, Jonathan Becker, Richard Göttlich

Publikováno v: Molecules, Vol 29, Iss 11, p 2432 (2024)

A microwave-assisted synthesis of dialkyl and cyclic H-phosphonates via bis(2,2,2 trifluoroethyl) phosphonate (BTFEP) is described. This method enables the synthesis of various cyclic H-phosphonates and hetero-substituted dialkyl H-phosphonates by si

Externí odkaz: https://doaj.org/article/cd32cf9a3c604702b30d158f8f64c623

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Akademický článek

Bis-3-Chloropiperidines Targeting TAR RNA as A Novel Strategy to Impair the HIV-1 Nucleocapsid Protein

Autor: Alice Sosic, Giulia Olivato, Caterina Carraro, Richard Göttlich, Dan Fabris, Barbara Gatto

Publikováno v: Molecules, Vol 26, Iss 7, p 1874 (2021)

Specific RNA sequences regulate functions essential to life. The Trans-Activation Response element (TAR) is an RNA stem–bulge–loop structure involved in several steps of HIV-1 replication. In this work, we show how RNA targeting can inhibit HIV-1

Externí odkaz: https://doaj.org/article/f3527f9303274e92be19f155f99a1b3b

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Akademický článek

Intermolecular addition reactions of N-alkyl-N-chlorosulfonamides to unsaturated compounds

Autor: Gerold Heuger, Richard Göttlich

Publikováno v: Beilstein Journal of Organic Chemistry, Vol 11, Iss 1, Pp 1226-1234 (2015)

N-Alkyl-N-chlorosulfonamides add to alkenes under copper(I) catalysis. In reactions of styrene derivatives with terminal double bonds the addition products were obtained in excellent yield and high regioselectivity. Lower yields are obtained in addit

Externí odkaz: https://doaj.org/article/8e8851d3f4bd44eaa02a819b544d61e5

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Aromatic Linkers Unleash the Antiproliferative Potential of 3‐Chloropiperidines Against Pancreatic Cancer Cells

Autor: Alice Sosic, Alexander Francke, Barbara Gatto, Richard Göttlich, Valentina Gandin, Michele De Franco, Tim Helbing, Caterina Carraro

Publikováno v: Chemmedchem

In this study, we describe the synthesis and biological evaluation of a set of bis‐3‐chloropiperidines (B−CePs) containing rigid aromatic linker structures. A modification of the synthetic strategy also enabled the synthesis of a pilot tris‐3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cca32e4fc16e0d6dd292745e2448ec0
https://doi.org/10.1002/cmdc.202000457

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