Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Richard G, Kay"'
Autor:
Ionel Sandovici, Denise S. Fernandez-Twinn, Niamh Campbell, Wendy N. Cooper, Yoichi Sekita, Ilona Zvetkova, David Ferland-McCollough, Haydn M. Prosser, Lila M. Oyama, Lucas C. Pantaleão, Danilo Cimadomo, Karina Barbosa de Queiroz, Cecilia S.K. Cheuk, Nicola M. Smith, Richard G. Kay, Robin Antrobus, Katharina Hoelle, Marcella K.L. Ma, Noel H. Smith, Stefan H. Geyer, Lukas F. Reissig, Wolfgang J. Weninger, Kenneth Siddle, Anne E. Willis, Brian Y.H. Lam, Martin Bushell, Susan E. Ozanne, Miguel Constância
Publikováno v:
Cell Reports, Vol 43, Iss 9, Pp 114750- (2024)
Summary: Mir483 is a conserved and highly expressed microRNA in placental mammals, embedded within the Igf2 gene. Its expression is dysregulated in a number of human diseases, including metabolic disorders and certain cancers. Here, we investigate th
Externí odkaz:
https://doaj.org/article/abbc32c9c19d41bf953422abe96dc435
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
IntroductionMotilin is a hormone secreted by specialised enteroendocrine cells in the small intestine, and is known to modulate gastrointestinal motility in humans, regulating the migratory motor complex. It is understudied at least in part due to th
Externí odkaz:
https://doaj.org/article/7a08dd0a587d436180ed385259c9be65
Autor:
Irene Cimino, Debra Rimmington, Y. C. Loraine Tung, Katherine Lawler, Pierre Larraufie, Richard G. Kay, Samuel Virtue, Brian Y. H. Lam, Luca Fagnocchi, Marcella K. L. Ma, Vladimir Saudek, Ilona Zvetkova, Antonio Vidal-Puig, Giles S. H. Yeo, I. Sadaf Farooqi, J. Andrew Pospisilik, Fiona M. Gribble, Frank Reimann, Stephen O’Rahilly, Anthony P. Coll
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Neuronatin (Nnat) has previously been reported to be part of a network of imprinted genes downstream of the chromatin regulator Trim28. Disruption of Trim28 or of members of this network, including neuronatin, results in an unusual phenotype
Externí odkaz:
https://doaj.org/article/e7d5a888c2a540aeac4077803967b5d5
Autor:
Tina Napso, Xiaohui Zhao, Marta Ibañez Lligoña, Ionel Sandovici, Richard G. Kay, Amy L. George, Fiona M. Gribble, Frank Reimann, Claire L. Meek, Russell S. Hamilton, Amanda N. Sferruzzi-Perri
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-17 (2021)
Napso et al. identify proteins from mouse placental endocrine cells and create a comprehensive secretome map of the placenta. The authors compare this secretome map with human placental datasets from women with pregnancy complications and demonstrate
Externí odkaz:
https://doaj.org/article/ff2b898ea1e54b2b8684c6ba582ddc31
Autor:
Emily L. Miedzybrodzka, Rachel E. Foreman, Van B. Lu, Amy L. George, Christopher A. Smith, Pierre Larraufie, Richard G. Kay, Deborah A. Goldspink, Frank Reimann, Fiona M. Gribble
Publikováno v:
Molecular Metabolism, Vol 54, Iss , Pp 101356- (2021)
Objective: Motilin is a proximal small intestinal hormone with roles in gastrointestinal motility, gallbladder emptying, and hunger initiation. In vivo motilin release is stimulated by fats, bile, and duodenal acidification but the underlying molecul
Externí odkaz:
https://doaj.org/article/7038fb1fad7e44e6bafe941133cf6234
Autor:
Lawrence J. Billing, Pierre Larraufie, Jo Lewis, Andrew Leiter, Joyce Li, Brian Lam, Giles SH. Yeo, Deborah A. Goldspink, Richard G. Kay, Fiona M. Gribble, Frank Reimann
Publikováno v:
Molecular Metabolism, Vol 29, Iss , Pp 158-169 (2019)
Objective: Enteroendocrine cells (EECs) of the large intestine, found scattered in the epithelial layer, are known to express different hormones, with at least partial co-expression of different hormones in the same cell. Here we aimed to categorize
Externí odkaz:
https://doaj.org/article/880adfcb0c684885b7974b0937ab2141
Autor:
Emily L. Miedzybrodzka, Rachel E. Foreman, Sam G. Galvin, Pierre Larraufie, Amy L. George, Deborah A. Goldspink, Frank Reimann, Fiona M. Gribble, Richard G. Kay
Publikováno v:
STAR Protocols, Vol 1, Iss 3, Pp 100164- (2020)
Summary: This protocol describes the peptidomic analysis of organoid lysates, FACS-purified cell populations, and 2D culture secretions by liquid chromatography mass spectrometry (LC-MS). Currently, most peptides are quantified by ELISA, limiting the
Externí odkaz:
https://doaj.org/article/a142a25934e846f4b27a6c18f2bc79b4
Autor:
Deborah A. Goldspink, Van B. Lu, Emily L. Miedzybrodzka, Christopher A. Smith, Rachel E. Foreman, Lawrence J. Billing, Richard G. Kay, Frank Reimann, Fiona M. Gribble
Publikováno v:
Cell Reports, Vol 31, Iss 13, Pp 107833- (2020)
Summary: Glucagon-like peptide-1 (GLP-1) from intestinal L-cells stimulates insulin secretion and reduces appetite after food ingestion, and it is the basis for drugs against type-2 diabetes and obesity. Drugs targeting L- and other enteroendocrine c
Externí odkaz:
https://doaj.org/article/afe639a516f74f0cacef5f0a9acfdb57
Autor:
Peter Kirwan, Richard G. Kay, Bas Brouwers, Vicente Herranz-Pérez, Magdalena Jura, Pierre Larraufie, Julie Jerber, Jason Pembroke, Theresa Bartels, Anne White, Fiona M. Gribble, Frank Reimann, I. Sadaf Farooqi, Stephen O'Rahilly, Florian T. Merkle
Publikováno v:
Molecular Metabolism, Vol 17, Iss , Pp 82-97 (2018)
Objective: The lack of pro-opiomelanocortin (POMC)-derived melanocortin peptides results in hypoadrenalism and severe obesity in both humans and rodents that is treatable with synthetic melanocortins. However, there are significant differences in POM
Externí odkaz:
https://doaj.org/article/a61f42e653954d9a945781cd864e4404
Autor:
Lawrence J. Billing, Christopher A. Smith, Pierre Larraufie, Deborah A. Goldspink, Sam Galvin, Richard G. Kay, Jonathan D. Howe, Ryan Walker, Mihai Pruna, Leslie Glass, Ramona Pais, Fiona M. Gribble, Frank Reimann
Publikováno v:
Molecular Metabolism, Vol 16, Iss , Pp 65-75 (2018)
Objective: Insulin-like peptide-5 (INSL5) is an orexigenic gut hormone found in a subset of colonic and rectal enteroendocrine L-cells together with the anorexigenic hormones glucagon-like peptide-1 (GLP-1) and peptideYY (PYY). Unlike GLP-1 and PYY,
Externí odkaz:
https://doaj.org/article/15266b662de9491591e17a5aadc4ad21