Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Richard F.G. Fröhlich"'
Autor:
Vern L. Schramm, Mu Feng, Rajesh K. Harijan, Morais Brown, Lawrence Harris, Richard F.G. Fröhlich, Peter C. Tyler
Publikováno v:
Biochemistry. 60:1933-1946
Helicobacter pylori is a Gram-negative bacterium that is responsible for gastric and duodenal ulcers. H. pylori uses the unusual mqn pathway with aminofutalosine (AFL) as an intermediate for menaquinone biosynthesis. Previous reports indicate that hy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b67baa1939432a6a4c06125c295dff4a
https://doi.org/10.1021/acs.biochem.1c00215
https://doi.org/10.1021/acs.biochem.1c00215
Autor:
Yong Zhang, Keith Clinch, Vern L. Schramm, Gary B. Evans, Richard F.G. Fröhlich, Maria B. Cassera, Lawrence Harris, Douglas R. Crump, Keith Z. Hazleton, Peter C. Tyler
Publikováno v:
Journal of Biological Chemistry. 288:34746-34754
The survival and proliferation of Plasmodium falciparum parasites and human cancer cells require de novo pyrimidine synthesis to supply RNA and DNA precursors. Orotate phosphoribosyltransferase (OPRT) is an indispensible component in this metabolic p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::218e74aa779f4e58a2569068ec4559b5
https://doi.org/10.1074/jbc.m113.521955
https://doi.org/10.1074/jbc.m113.521955
Publikováno v:
Carbohydrate Research
Graphical abstract
A synthetic route to a trifluoromethyl and thiol containing glucose derivative (2,2,2-trifluoroethyl 6-thio-β-d-glucopyranoside) is presented, which is based on microwave-assisted Fischer glycosylation under increased pressur
A synthetic route to a trifluoromethyl and thiol containing glucose derivative (2,2,2-trifluoroethyl 6-thio-β-d-glucopyranoside) is presented, which is based on microwave-assisted Fischer glycosylation under increased pressur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51c4c0d02aa55680ce98c3766d2a5659
https://doi.org/10.1016/j.carres.2012.08.010
https://doi.org/10.1016/j.carres.2012.08.010
Autor:
Schramm Vern L, Keith Clinch, Shivali A. Gulab, Jemy A. Gutierrez, Gary B. Evans, Jennifer M. Mason, Richard F.G. Fröhlich, Anthony D. Woolhouse, Peter C. Tyler
Publikováno v:
Bioorganic & Medicinal Chemistry. 20:5181-5187
Several acyclic hydroxy-methylthio-amines with 3–5 carbon atoms were prepared and coupled via a methylene link to 9-deazaadenine. The products were tested for inhibition against human MTAP and Escherichia coli and Neisseria meningitidis MTANs and g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::945e01fa067cfae791bfc82847049a7c
https://doi.org/10.1016/j.bmc.2012.07.006
https://doi.org/10.1016/j.bmc.2012.07.006
Autor:
Michael B. Tropak, Tanja M. Wrodnigg, Stephen G. Withers, Robert Saf, Richard F.G. Fröhlich, Richard H. Furneaux, Don J. Mahuran, Jacqueline Wicki, Arnold E. Stütz
Publikováno v:
Carbohydrate Research
Graphical abstract Highlights ► N-Alkylation of 1-deoxy-D-galactonojirimycin with dansylamino terminated spacer arms provides powerful inhibitors. ► These enhance mutant lysosomal -galactosidase activities in GM1 gangliosidosis cell lines. ► Ba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b4ad05a6b49003e49ff9e28f0d58c93
Publikováno v:
Journal of the American Chemical Society. 129:6872-6879
Transition state theory suggests that enzymatic rate acceleration (kcat/knon) is related to the stabilization of the transition state for a given reaction. Chemically stable analogues of a transition state complex are predicted to convert catalytic e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7a38e6e83cf41f54aed456c331c0e46
https://doi.org/10.1021/ja0708363
https://doi.org/10.1021/ja0708363
Autor:
Meng-Chiao Ho, Peter C. Tyler, Richard F.G. Fröhlich, Steven C. Almo, Vern L. Schramm, Rong Guan
Publikováno v:
Biochemistry. 51(45)
Pseudomonas aeruginosa possesses an unusual pathway for 5'-methylthioadenosine (MTA) metabolism involving deamination to 5'-methylthioinosine (MTI) followed by N-ribosyl phosphorolysis to hypoxanthine and 5-methylthio-α-d-ribose 1-phosphate. The spe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02140a9a268b031f9e11274b4e1de1b9
https://pubmed.ncbi.nlm.nih.gov/23050701
https://pubmed.ncbi.nlm.nih.gov/23050701
Autor:
Eduard Paschke, Stephen G. Withers, Arnold E. Stütz, Richard H. Furneaux, Tanja M. Wrodnigg, Jacqueline Wicki, Katrin Fantur, Richard F.G. Fröhlich
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(22)
N-(Dansylamino)hexylaminocarbonylpentyl-1,5-dideoxy-1,5-imino-d-galactitol, a strong competitive inhibitor of β-galactosidase, enhances residual β-galactosidase activities in fibroblasts and serves as lead en route to diagnostic compounds for track
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6519b8560e1ba82713f05511a9f3f177
https://pubmed.ncbi.nlm.nih.gov/21974950
https://pubmed.ncbi.nlm.nih.gov/21974950
Autor:
Stephen G. Withers, Don J. Mahuran, Richard H. Furneaux, Michael B. Tropak, Tanja M. Wrodnigg, Arnold E. Stütz, Brigitte Rigat, Richard F.G. Fröhlich, Jacqueline Wicki
Cyclization by double reductive amination of d - xylo -hexos-5-ulose with methyl 6-aminohexanoate gave (methoxycarbonyl)pentyl-1-deoxynojirimycin. Reaction of the terminal carboxylic acid with N -dansyl-1,6-diaminohexane provided the corresponding ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d48ea5e92c0daa647132bf7a84d62ec2
https://europepmc.org/articles/PMC3201982/
https://europepmc.org/articles/PMC3201982/
Publikováno v:
Acta Crystallographica Section E: Structure Reports
The title compound, C(12)H(16)N(4)O(3)S·H(2)O, which has potential as a possible anti-malarial drug, was studied when small deviations in melting points, for two differently aged preparations, were observed. The unexpected existence of a water mol-e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::985b1f20ade1de3d9e1bc398e4624861
https://pubmed.ncbi.nlm.nih.gov/21587912
https://pubmed.ncbi.nlm.nih.gov/21587912