Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Richard F. Lyman"'
Autor:
Katelynne M. Collins, Elisabeth Howansky, Sarah C. Macon-Foley, Maria E. Adonay, Vijay Shankar, Richard F. Lyman, Nestor Octavio Nazario-Yepiz, Jordyn K. Brooks, Rachel A. Lyman, Trudy F. C. Mackay, Robert R. H. Anholt
Publikováno v:
Human Genomics, Vol 18, Iss 1, Pp 1-14 (2024)
Abstract Background 4-methylimidazole is a ubiquitous and potentially carcinogenic environmental toxicant. Genetic factors that contribute to variation in susceptibility to its toxic effects are challenging to assess in human populations. We used the
Externí odkaz:
https://doaj.org/article/e59933fe43b04c80965ccab72c2b6d57
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Huang et al. show that developing under different temperatures changes the genetic architecture of regulatory variation in Drosophila melanogaster gene expression yet the co-expression network remains robust. Data suggest that stabilizing selection o
Externí odkaz:
https://doaj.org/article/6a61c4dc8259471cb7b8dcfc716eb7c7
Autor:
Richard F. Lyman, Rachel A. Lyman, Akihiko Yamamoto, Wen Huang, Susan T. Harbison, Shanshan Zhou, Robert R. H. Anholt, Trudy F. C. Mackay
Fertility is a major component of fitness but its genetic architecture remains poorly understood. Using a full diallel cross of 50 Drosophila melanogaster Genetic Reference Panel inbred lines with full genome sequences, we found substantial genetic v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c53c19102c343f833bc4773966edd51
https://doi.org/10.1101/2022.09.06.506722
https://doi.org/10.1101/2022.09.06.506722
Autor:
Wen Huang, Richard F Lyman, Rachel A Lyman, Mary Anna Carbone, Susan T Harbison, Michael M Magwire, Trudy FC Mackay
Publikováno v:
eLife, Vol 5 (2016)
Externí odkaz:
https://doaj.org/article/d0f0f5320eea4f09932fcac04f28bf8e
Autor:
Wen Huang, Richard F Lyman, Rachel A Lyman, Mary Anna Carbone, Susan T Harbison, Michael M Magwire, Trudy FC Mackay
Publikováno v:
eLife, Vol 5 (2016)
Mutation and natural selection shape the genetic variation in natural populations. Here, we directly estimated the spontaneous mutation rate by sequencing new Drosophila mutation accumulation lines maintained with minimal natural selection. We inferr
Externí odkaz:
https://doaj.org/article/beee1b02c57b454791f8d7e7594ea44b
Autor:
Robert R. H. Anholt, Fabio Morgante, Richard F. Lyman, Matthew S. Geisz, Wen Huang, Genevieve St. Armour, Shanshan Zhou, Lavanya Turlapati, Junwu Ma, Logan J. Everett, Mary Anna Carbone, Trudy F. C. Mackay, Gunjan H. Arya
Publikováno v:
Genome Research. 30:485-496
A major challenge in modern biology is to understand how naturally occurring variation in DNA sequences affects complex organismal traits through networks of intermediate molecular phenotypes. This question is best addressed in a genetic mapping popu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60a66b05b0b295e107413c24b2f05819
https://doi.org/10.1101/gr.257592.119
https://doi.org/10.1101/gr.257592.119
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Nature Communications
Nature Communications
The genetics of phenotypic responses to changing environments remains elusive. Using whole-genome quantitative gene expression as a model, here we study how the genetic architecture of regulatory variation in gene expression changed in a population o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e63b09cb962c4a7352a0820f106f6423
https://doi.org/10.1038/s41467-020-19131-y
https://doi.org/10.1038/s41467-020-19131-y
The genetics of phenotypic responses to changing environments remains elusive. Using whole genome quantitative gene expression as a model, we studied how the genetic architecture of regulatory variation in gene expression changed in a population of f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26a5df7a20798eaad3f0285c3ee50c51
https://doi.org/10.1101/2020.06.23.163501
https://doi.org/10.1101/2020.06.23.163501
Autor:
Jan O. Korbel, Richard A. Gibbs, Sandy Lee, David Mittelman, Divya Kalra, Yuanqing Wu, Michael M. Magwire, Richard F. Lyman, Aneisa Williams, Crystal B. Warner, Nehad Saada, Mehwish Javaid, Wen Huang, Mary Anna Carbone, Bart Deplancke, Stephanie M. Rollmann, Lora Perales, Robert R. H. Anholt, Yutaka Inoue, Yi Han, Stephen Richards, Agapito Perez, Thomas Zichner, J. Spencer Johnston, Andreas Massouras, Trudy F. C. Mackay, Akihiko Yamamoto, Aaron M. Tarone, Lavanya Turlapati, Eric A. Stone, Lisa L. Ellis, Donna M. Muzny, Shohba Patel, Kyle Chang, Antonio Barbadilla, Mala Munidasa, Sonia Fernandez, Yiqing Zhang, Ling-Ling Pu, Fiona Ongeri, Robert Ruth, Jason A. Peiffer, Lora Lewis, Miquel Ràmia, Gareth Highnam, Joy Jayaseelan, Kerstin P. Blankenburg, John Jack, Carl E. Hjelmen, Dianhui Zhu, Yiming Zhu
Publikováno v:
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
GENOME RESEARCH
Universitat Autònoma de Barcelona
GENOME RESEARCH
The Drosophila melanogaster Genetic Reference Panel (DGRP) is a community resource of 205 sequenced inbred lines, derived to improve our understanding of the effects of naturally occurring genetic variation on molecular and organismal phenotypes. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2003da1b73a314fe5ee411d69880228
https://doi.org/10.1101/gr.171546.113
https://doi.org/10.1101/gr.171546.113
Autor:
Richard F. Lyman, Susan T. Harbison, Mary Anna Carbone, Trudy F. C. Mackay, Michael M. Magwire, Wen Huang, Rachel A Lyman
Publikováno v:
eLife, Vol 5 (2016)
A key challenge in evolutionary biology is to understand how genetic variation – differences in the DNA of individuals in a population – is generated and maintained to create the enormous diversity that exists in nature. Mutations to the DNA intr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bee9469244e33eb5df430c33dd937bc3
https://doi.org/10.7554/elife.14625
https://doi.org/10.7554/elife.14625