Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Richard F. Hank"'
Autor:
Ketan S. Gajiwala, Dongxiang Zeng, Jeffrey A. Pfefferkorn, Francis Bourbonais, Christopher S. Jones, Michael J. Hickey, Christian Perreault, Paul S. Humphries, Robert John Maguire, Jianwei Bian, Shenping Liu, Kevin J. Filipski, Mary Theresa Didiuk, Meihua Tu, Gary Erik Aspnes, David R. Derksen, Robert L. Dow, Angel Guzman-Perez, Richard F. Hank, Theodore O. Johnson, John Litchfield, John D. Knafels, Karen Atkinson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:4571-4578
Glucokinase activators are a class of experimental agents under investigation as a therapy for Type 2 diabetes mellitus. An X-ray crystal structure of a modestly potent agent revealed the potential to substitute the common heterocyclic amide donor–
Autor:
Michael G. Lopaze, Michael Hamilton, Michael John Munchhof, Sophie Y. Lavergne, Michael P. DeNinno, Cuiman Cai, Kentaro Futatsugi, Yue Chen, Amit S. Kalgutkar, Cathy Préville, Ralph P. Robinson, Vincent Mascitti, Anthony R. Harris, Stephen W. Wright, Peter Cornelius, Daniel W. Kung, Kim F. McClure, Cristiano Ruch Werneck Guimarães, Paul D. Bonin, Bruce Allen Lefker, Hua Gao, Richard F. Hank, Nao Morishita
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:194-197
A novel GPR119 agonist based on the 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole scaffold was designed through lead optimization starting from pyrazole-based GPR119 agonist 1. The design is centered on the conformational restriction of the core scaffold,
Autor:
Brian Manning, Mary Campbell, Demetria Debartola, Michael G. Lopaze, Roger Swartz, Daniel W. Kung, Colin R. Rose, Bruce A. Posner, Zachary S. Hendsch, Richard F. Hank, Steven B. Coffey, Michael Fichtner, Christopher F. Wielis, Hou Tommy Chen, Rachel Kosa-Maines, Shawn Cabral, Stefanus J. Steyn, Philip A. Carpino, Wenhua Jiao, Jeffrey S. Dubins, Ryan Jones, Ingrid A. Stock, Kim F. McClure, Sam Varma
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:4281-4287
The discovery of spirocyclic piperidine-azetidine inverse agonists of the ghrelin receptor is described. The characterization and redressing of the issues associated with these compounds is detailed. An efficient three-step synthesis and a binding as
Autor:
Paul DaSilva-Jardine, Josephine Spitzer, Michele H. Rosner, Samuel P. Simons, Diane M. Hargrove, Boris A. Chrunyk, Richard F. Hank, Phoebe Chiang, Ernest S. Paight, Swick Andrew Gordon, Robert L. Dow, Peter Cornelius, Gayle K. Schulte, Tate Bonnie Frances, Steven R. Schneider, Terrell A. Patterson, William P. Newsome, Jayvardhan Pandit, Mark Ammirati, Eunsun Lee, Dennis E. Danley, Peter K. LeMotte
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:379-382
In this communication, we wish to describe the discovery of a novel series of 6-azauracil-based thyromimetics that possess up to 100-fold selectivities for binding and functional activation of the beta(1)-isoform of the thyroid receptor family. Struc
Autor:
Ray Partha Sarathi, Richard F. Hank
Publikováno v:
Journal of Heterocyclic Chemistry. 27:2017-2020
The reaction of acetone arylhydrazones with acetyl isocyanate gave the corresponding 4-acetyl-1-aryl-3,3-dimethyl-1,2,4-triazolidin-5-ones which eliminated acetone upon acidic hydrolysis to give 1-aryl-3-methyl-1,2,-4-triazolin-5-ones. The above tran
Autor:
R W Stevenson, James V. Cassella, Richard F. Hank, Melissa L. Gillaspy, Janet A. LaFlamme, Tristan S. Maurer, Richard L. Elliott, Marlys Hammond, Demetria L. Baker, Paul DaSilva-Jardine, Robert M. Oliver, Christine M. Mack
Publikováno v:
Bioorganicmedicinal chemistry letters. 13(20)
A series of 2-heteroaryl-4-arylimidazoles with potent in vitro activity at the NPY5 receptor was developed. Introduction of electron-withdrawing groups on the 4-aryl ring led to a significant improvement of in vitro potency. Several analogues from th
Autor:
Harry O. Tobiassen, Bryan Li, Joshua Roth, Murry Jerry Anthony, Richard F. Hank, Chiu Charles K
Publikováno v:
Organic Process Research & Development. 6:682-683
The preparation of 2,4-disubstituted imidazoles from the condensation of α-haloketones with amidines is described. The optimal reaction protocol is to add the α-bromoketone solution to the amidine in aqueous tetrahydrofuran in the presence of potas