Zobrazeno 1 - 10
of 164
pro vyhledávání: '"Richard F Ludueña"'
Autor:
Marc St George, Ahmed T Ayoub, Asok Banerjee, Cassandra D M Churchill, Philip Winter, Mariusz Klobukowski, Carol E Cass, Richard F Ludueña, Jack A Tuszynski, Sambasivarao Damaraju
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0129168 (2015)
Our previous work identified an intermediate binding site for taxanes in the microtubule nanopore. The goal of this study was to test derivatives of paclitaxel designed to bind to this intermediate site differentially depending on the isotype of β-t
Externí odkaz:
https://doaj.org/article/f52f0efb56234a809812dbd19309eb40
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Microtubules are organelles that usually occur only in the cytosol. Walss et al. (1999) discovered the βII isotype of tubulin, complexed with α, in the nuclei of certain cultured cells, in non-microtubule form. When fluorescently labeled tubulins w
Externí odkaz:
https://doaj.org/article/df821f9d58474814a703fedbf2506949
Autor:
Richard F. Ludueña
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
Microtubules, are formed of the protein tubulin, which is a heterodimer of α- and β-tubulin subunits. Both α- and β-tubulin exist as numerous isotypes, differing in amino acid sequence and tissue distribution. Among the vertebrate β isotypes, β
Externí odkaz:
https://doaj.org/article/bf099f3d01fe4745a7fcd5944a17e8ef
Autor:
Susan L. Mooberry, Gary D. Kruh, Richard F. Ludueña, Elizabeth Hopper-Borge, Patrick A. Joe, Desiree A. LeBoeuf, Gregory L. Helms, Lisa A. Polin, Evelyn M. Jackson, April L. Risinger
Supplementary Figure 1 from The Taccalonolides: Microtubule Stabilizers That Circumvent Clinically Relevant Taxane Resistance Mechanisms
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11efd5300b02f7ab0da4493f255ec0fd
https://doi.org/10.1158/0008-5472.22376409
https://doi.org/10.1158/0008-5472.22376409
Autor:
Susan L. Mooberry, Gary D. Kruh, Richard F. Ludueña, Elizabeth Hopper-Borge, Patrick A. Joe, Desiree A. LeBoeuf, Gregory L. Helms, Lisa A. Polin, Evelyn M. Jackson, April L. Risinger
Supplementary Figure 2 from The Taccalonolides: Microtubule Stabilizers That Circumvent Clinically Relevant Taxane Resistance Mechanisms
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2de89e87dba5c29268c7469d6a928b31
https://doi.org/10.1158/0008-5472.22376406
https://doi.org/10.1158/0008-5472.22376406
Autor:
Susan L. Mooberry, Gary D. Kruh, Richard F. Ludueña, Elizabeth Hopper-Borge, Patrick A. Joe, Desiree A. LeBoeuf, Gregory L. Helms, Lisa A. Polin, Evelyn M. Jackson, April L. Risinger
Supplementary Figure 3 from The Taccalonolides: Microtubule Stabilizers That Circumvent Clinically Relevant Taxane Resistance Mechanisms
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8df7b46b7b0423e3c7d5ddbf4125ab07
https://doi.org/10.1158/0008-5472.22376403
https://doi.org/10.1158/0008-5472.22376403
Autor:
Susan L. Mooberry, Gary D. Kruh, Richard F. Ludueña, Elizabeth Hopper-Borge, Patrick A. Joe, Desiree A. LeBoeuf, Gregory L. Helms, Lisa A. Polin, Evelyn M. Jackson, April L. Risinger
Supplementary Legends from The Taccalonolides: Microtubule Stabilizers That Circumvent Clinically Relevant Taxane Resistance Mechanisms
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15395f5a957574f6e8415bce64686373
https://doi.org/10.1158/0008-5472.22376400
https://doi.org/10.1158/0008-5472.22376400
Publikováno v:
Cytoskeleton. 75:283-289
Microtubules are a major component of the neuronal cytoskeleton. Tubulin, the subunit protein of microtubules, is an α/β heterodimer. Both α and β exist as families of isotypes, whose members are encoded by different genes and have different amin
Autor:
Alexander L. Weis, Veena Prasad, I-Tien Yeh, Asok Banerjee, John C. Lee, Richard F. Ludueña, Lee Chuan C Yeh, Tamas Bakos, Jack A. Tuszynski
Publikováno v:
Investigational New Drugs. 34:129-137
The subunit protein of microtubules is tubulin, which has been the target for some of the most successful and widely used anti-tumor drugs. Most of the drugs that target tubulin bind to the β subunit. There are many isotypes of β-tubulin and their
Autor:
Aja M. Rieger, Jack A. Tuszynski, Lorelei Johnson, Bashar Hassani, Torin Huzil, Asok Banerjee, Richard F. Ludueña, Philip Winter, Jonathan Y. Mane, Ing Swie Goping
Publikováno v:
Current Topics in Medicinal Chemistry. 17
In this paper we provide an overview of the status of various colchicine derivatives in pre-clinical development with special focus on their anti-cancer activity. We discuss several groups of compounds that have been designed to differentially bind w