Zobrazeno 1 - 10
of 176
pro vyhledávání: '"Richard E. Taylor"'
Autor:
Sara E. Kearney, Gergely Zahoránszky-Kőhalmi, Kyle R. Brimacombe, Mark J. Henderson, Caitlin Lynch, Tongan Zhao, Kanny K. Wan, Zina Itkin, Christopher Dillon, Min Shen, Dorian M. Cheff, Tobie D. Lee, Danielle Bougie, Ken Cheng, Nathan P. Coussens, Dorjbal Dorjsuren, Richard T. Eastman, Ruili Huang, Michael J. Iannotti, Surendra Karavadhi, Carleen Klumpp-Thomas, Jacob S. Roth, Srilatha Sakamuru, Wei Sun, Steven A. Titus, Adam Yasgar, Ya-Qin Zhang, Jinghua Zhao, Rodrigo B. Andrade, M. Kevin Brown, Noah Z. Burns, Jin K. Cha, Emily E. Mevers, Jon Clardy, Jason A. Clement, Peter A. Crooks, Gregory D. Cuny, Jake Ganor, Jesus Moreno, Lucas A. Morrill, Elias Picazo, Robert B. Susick, Neil K. Garg, Brian C. Goess, Robert B. Grossman, Chambers C. Hughes, Jeffrey N. Johnston, Madeleine M. Joullie, A. Douglas Kinghorn, David G.I. Kingston, Michael J. Krische, Ohyun Kwon, Thomas J. Maimone, Susruta Majumdar, Katherine N. Maloney, Enas Mohamed, Brian T. Murphy, Pavel Nagorny, David E. Olson, Larry E. Overman, Lauren E. Brown, John K. Snyder, John A. Porco, Fatima Rivas, Samir A. Ross, Richmond Sarpong, Indrajeet Sharma, Jared T. Shaw, Zhengren Xu, Ben Shen, Wei Shi, Corey R.J. Stephenson, Alyssa L. Verano, Derek S. Tan, Yi Tang, Richard E. Taylor, Regan J. Thomson, David A. Vosburg, Jimmy Wu, William M. Wuest, Armen Zakarian, Yufeng Zhang, Tianjing Ren, Zhong Zuo, James Inglese, Sam Michael, Anton Simeonov, Wei Zheng, Paul Shinn, Ajit Jadhav, Matthew B. Boxer, Matthew D. Hall, Menghang Xia, Rajarshi Guha, Jason M. Rohde
Publikováno v:
ACS Central Science, Vol 4, Iss 12, Pp 1727-1741 (2018)
Externí odkaz:
https://doaj.org/article/9f2975f36dd648f0b92b6e0f2b27c087
Publikováno v:
International Journal of Molecular Sciences, Vol 18, Iss 3, p 648 (2017)
The synthesis of two deoxygenated analogues of potent epothilones is reported in an effort to analyze the relative importance of molecular conformation and ligand–target interactions to biological activity. 7-deoxy-epothilone D and 7-deoxy-(S)-14-m
Externí odkaz:
https://doaj.org/article/aa67d7c18db548f1b090847f67db0e5e
Autor:
Mark Sellin, Ryan Mack, Matthew C. Rhodes, Lei Zhang, Stephanie Berg, Kanak Joshi, Shanhui Liu, Wei Wei, Peter Breslin S. J., Peter Larsen, Richard E. Taylor, Jiwang Zhang
Publikováno v:
Br J Cancer
INTRODUCTION: Splice modulators have been assessed clinically in treating haematologic malignancies exhibiting splice factor mutations and acute myeloid leukaemia. However, the mechanisms by which such modulators repress leukaemia remain to be elucid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e88a491a686ac6d9a9fdc08b6294bbc9
https://doi.org/10.1038/s41416-022-01796-5
https://doi.org/10.1038/s41416-022-01796-5
Autor:
Hoyer Denton W, Anna‐Lena Gustavsson, Vadim J. Gurvich, Al Edwards, Paul D. Andrews, Daniel Ebner, Stephen Frye, Denise Barrault, Erik Chorell, Peter I. Dosa, Neil O. Carragher, Michael R. Myers, Gunda I. Georg, Hirotatsu Kojima, Andrew M. Hopkins, Richard E. Taylor, Michael A. Walters, Roland E. Dolle, Jon E. Hawkinson
Publikováno v:
Burger's Medicinal Chemistry and Drug Discovery
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c793d4a81b6a519d10e654b68a793b4
https://doi.org/10.1002/0471266949.bmc292
https://doi.org/10.1002/0471266949.bmc292
Autor:
James D. Thomas, Sydney X. Lu, Emma De Neef, Erich Sabio, Benoit Rousseau, Mathieu Gigoux, David A. Knorr, Benjamin Greenbaum, Yuval Elhanati, Simon J. Hogg, Andrew Chow, Arnab Ghosh, Abigail Xie, Dmitriy Zamarin, Daniel Cui, Caroline Erickson, Michael Singer, Hana Cho, Eric Wang, Bin Lu, Benjamin H. Durham, Harshal Shah, Diego Chowell, Austin M. Gabel, Yudao Shen, Jing Liu, Jian Jin, Matthew C. Rhodes, Richard E. Taylor, Henrik Molina, Jedd D. Wolchok, Taha Merghoub, Luis A. Diaz Jr, Omar Abdel-Wahab, Robert K. Bradley
Publikováno v:
Cancer Research. 83:5742-5742
Immune checkpoint blockade therapy has revolutionized cancer care, including the treatment of advanced metastatic disease. However, most patients derive little or no clinical benefit from these therapies and many cancer types are notoriously non-resp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45c0af3bac542e8bbd2cc944793d3e1f
https://doi.org/10.1158/1538-7445.am2023-5742
https://doi.org/10.1158/1538-7445.am2023-5742
Autor:
Jeffrey L. Henry, Matthew R. Wilson, Taylor R. Quinn, Richard E. Taylor, Dan L. Sackett, Michael P. Mulligan
Publikováno v:
MedChemComm. 10:800-805
Zampanolide and dactylolide are microtubule-stabilizing polyketides possessing potent cytotoxicity towards a variety of cancer cell lines. Using our understanding of the conformational preferences of the macrolide core in both natural products, we hy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91c799323a839209d85520f2a09366b7
https://doi.org/10.1039/c9md00164f
https://doi.org/10.1039/c9md00164f
Autor:
Rajarshi Guha, Anton Simeonov, Jesus Moreno, Min Shen, Yi Tang, James Inglese, Jared T. Shaw, Jimmy Ming-Tai Wu, Samir A. Ross, Tobie D. Lee, Surendra Karavadhi, Dorian M. Cheff, Susruta Majumdar, Adam Yasgar, Richard E. Taylor, Sam Michael, Zhengren Xu, Wei Sun, Lucas A. Morrill, David A. Vosburg, Wei Zheng, Corey R. J. Stephenson, Noah Z. Burns, Michael J. Iannotti, Carleen Klumpp-Thomas, Richard T. Eastman, Ohyun Kwon, Armen Zakarian, Yufeng Zhang, Matthew D. Hall, Sara E. Kearney, Ya Qin Zhang, Tongan Zhao, Ken Cheng, Indrajeet Sharma, Nathan P. Coussens, Ruili Huang, Derek S. Tan, Paul Shinn, Michael J. Krische, Caitlin Lynch, Jon Clardy, Larry E. Overman, Kanny K. Wan, Chambers C. Hughes, Madeleine M. Joullié, Thomas J. Maimone, Matthew B. Boxer, Jason A. Clement, A. Douglas Kinghorn, Peter A. Crooks, Brian C. Goess, Robert B. Susick, Gergely Zahoránszky-Kőhalmi, Alyssa L. Verano, Danielle Bougie, Jacob S. Roth, Ben Shen, Dorjbal Dorjsuren, Elias Picazo, Jinghua Zhao, John K. Snyder, Rodrigo B. Andrade, Wei Shi, Jin K. Cha, Brian T. Murphy, Fatima Rivas, William M. Wuest, Jake Ganor, Robert B. Grossman, Pavel Nagorny, Emily Mevers, Enas I. Mohamed, David E. Olson, John A. Porco, Neil K. Garg, Srilatha Sakamuru, Jason M. Rohde, M. Kevin Brown, Menghang Xia, Tianjing Ren, Steve Titus, Christopher Dillon, Mark J. Henderson, Zhong Zuo, Regan J. Thomson, David G. I. Kingston, Lauren E. Brown, Jeffrey N. Johnston, Katherine N. Maloney, Richmond Sarpong, Zina Itkin, Gregory D. Cuny, Ajit Jadhav, Kyle R. Brimacombe
Publikováno v:
ACS Central Science
ACS Central Science, Vol 4, Iss 12, Pp 1727-1741 (2018)
ACS Central Science, Vol 4, Iss 12, Pp 1727-1741 (2018)
Natural products and their derivatives continue to be wellsprings of nascent therapeutic potential. However, many laboratories have limited resources for biological evaluation, leaving their previously isolated or synthesized compounds largely or com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04c15680292ccf77cdc7f1e4318e2861
http://europepmc.org/articles/PMC6311695
http://europepmc.org/articles/PMC6311695
Publikováno v:
Chemistry
The family of anti-fungal natural products known as the ambruticins are structurally distinguished by a pair of pyran rings adorning a divinylcyclopropane core. Previous characterization of their biosynthesis, including the expression of a geneticall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b7c914f7b3a12c7064ce38e767e8e91
https://pubmed.ncbi.nlm.nih.gov/33887073
https://pubmed.ncbi.nlm.nih.gov/33887073
Autor:
Harrison A. Clarke, Craig W. Vander Kooi, Dustin D. Armstrong, Anna A. DePaoli-Roach, Richard R. Drake, Kia H. Markussen, Richard E. Taylor, Jessica K. A. Macedo, Lyndsay E.A. Young, Lindsey R. Conroy, Charles J. Waechter, Matthew S. Gentry, Ronald C. Bruntz, Ramon C. Sun, Christine Fillmore Brainson, Alexandra E. Stanback, Buyun Tang, William C. Sanders, Shane Emanuelle, Dyann M. Segvich, Elizabeth J. Allenger, M. Kathryn Brewer, Peter J. Roach, Krishna K. Mahalingan, Robert Shaffer, Annette Mestas, Vimbai M. Chikwana, Zhengqiu Zhou, Thomas D. Hurley, Tara R. Hawkinson, Alberto Rondon, Christopher J. Contreras, Lance A. Johnson
Publikováno v:
Cell Metab
Summary Glycosylation defects are a hallmark of many nervous system diseases. However, the molecular and metabolic basis for this pathology is not fully understood. In this study, we found that N-linked protein glycosylation in the brain is metabolic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::837412de53a30e091117ae4b28c80e34
https://pubmed.ncbi.nlm.nih.gov/34043942
https://pubmed.ncbi.nlm.nih.gov/34043942
Autor:
Eric Wang, Mathieu Gigoux, Sydney X. Lu, Benjamin H. Durham, Luis A. Diaz, Harshal Shah, Erich Sabio, Abigail Xie, Henrik Molina, Arnab Ghosh, Matthew C. Rhodes, Caroline Erickson, Jian Jin, Austin M. Gabel, Jedd D. Wolchok, Dmitriy Zamarin, Daniel Cui, Diego Chowell, Michael E Singer, Benjamin D. Greenbaum, Simon J. Hogg, Richard E. Taylor, James D. Thomas, Omar Abdel-Wahab, Taha Merghoub, Yudao Shen, Andrew Chow, Jing Liu, Hana Cho, David A. Knorr, Yuval Elhanati, Bin Lu, Emma De Neef, Benoit Rousseau, Robert K. Bradley
Publikováno v:
Cell. 184(15)
Summary Although mutations in DNA are the best-studied source of neoantigens that determine response to immune checkpoint blockade, alterations in RNA splicing within cancer cells could similarly result in neoepitope production. However, the endogeno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef3e48245d9aad97fd009882f5e4dc64
https://pubmed.ncbi.nlm.nih.gov/35121911
https://pubmed.ncbi.nlm.nih.gov/35121911