Zobrazeno 1 - 10
of 146
pro vyhledávání: '"Richard E. Kast"'
Autor:
Jong Hoon Lee, Consolato Sergi, Richard E. Kast, Badar A. Kanwar, Jean Bourbeau, Sangsuk Oh, Mun-Gi Sohn, Chul Joong Lee, Michael D. Coleman
Publikováno v:
Virology Journal, Vol 21, Iss 1, Pp 1-15 (2024)
Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induces immune-mediated diseases. The pathophysiology of COVID-19 uses the following three mechanisms: (1) inflammasome activation mechanism; (2) cGAS–STING signaling mechanism;
Externí odkaz:
https://doaj.org/article/499a6cd62daa4ec48434023b2df37b92
Autor:
Richard E. Kast
Publikováno v:
Neuroglia, Vol 5, Iss 3, Pp 223-233 (2024)
Glioblastomas synthesize, bear receptors for, and respond to bradykinin, triggering migration and proliferation. Since centrifugal migration into uninvolved surrounding brain tissue occurs early in the course of glioblastoma, this attribute defeats l
Externí odkaz:
https://doaj.org/article/8536adef598e4941a4d8c2215dc6bfb0
Autor:
Richard E. Kast
Publikováno v:
Cells, Vol 13, Iss 14, p 1175 (2024)
Lorlatinib is a pharmaceutical ALK kinase inhibitor used to treat ALK driven non-small cell lung cancers. This paper analyses the intersection of past published data on the physiological consequences of two unrelated drugs from general medical practi
Externí odkaz:
https://doaj.org/article/c5f80a8ac7be42f485cb6fed21d10d86
Autor:
Richard E. Kast
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 20, p 15474 (2023)
As things stand in 2023, metastatic osteosarcoma commonly results in death. There has been little treatment progress in recent decades. To redress the poor prognosis of metastatic osteosarcoma, the present regimen, OSR9, uses nine already marketed dr
Externí odkaz:
https://doaj.org/article/35c9aea15dc34d78b3e4282715c0332b
Dapsone Lowers Neutrophil to Lymphocyte Ratio and Mortality in COVID-19 Patients Admitted to the ICU
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 24, p 15563 (2022)
Some physicians use dapsone as part of the standard treatment of severe COVID-19 patients entering the ICU, though some do not. To obtain an indication of whether dapsone is helping or not, we undertook a retrospective chart review of 29 consecutive
Externí odkaz:
https://doaj.org/article/917268d89cb94202a8cab8460e3f1c7f
Autor:
Jong Hoon Lee, Badar Kanwar, Asif Khattak, Jenny Balentine, Ngoc Huy Nguyen, Richard E. Kast, Chul Joong Lee, Jean Bourbeau, Eric L. Altschuler, Consolato M. Sergi, Tuan Ngoc Minh Nguyen, Sangsuk Oh, Mun-Gi Sohn, Michael Coleman
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 21, p 13260 (2022)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induces immune-mediated type 1 interferon (IFN-1) production, the pathophysiology of which involves sterile alpha motif and histidine-aspartate domain-containing protein 1 (SAMHD1) tetramer
Externí odkaz:
https://doaj.org/article/0637e3002f5e48ef9036d19497a5850c
Autor:
Richard E. Kast
Publikováno v:
Cancers, Vol 14, Iss 19, p 4965 (2022)
This paper presents remarkably uniform data showing that higher NLR is a robust prognostic indicator of shorter overall survival across the common metastatic cancers. Myeloid derived suppressor cells, the NLRP3 inflammasome, neutrophil extracellular
Externí odkaz:
https://doaj.org/article/9e93da3f7dd64535810ab7b58586afdc
Autor:
Richard E. Kast, Alex Alfieri, Hazem I. Assi, Terry C. Burns, Ashraf M. Elyamany, Maria Gonzalez-Cao, Georg Karpel-Massler, Christine Marosi, Michael E. Salacz, Iacopo Sardi, Pieter Van Vlierberghe, Mohamed S. Zaghloul, Marc-Eric Halatsch
Publikováno v:
Cancers, Vol 14, Iss 10, p 2563 (2022)
In part one of this two-part paper, we present eight principles that we believe must be considered for more effective treatment of the currently incurable cancers. These are addressed by multidrug adjunctive cancer treatment (MDACT), which uses multi
Externí odkaz:
https://doaj.org/article/f689d38ad7e541139d612f74198ba3a5
Publikováno v:
Vaccines, Vol 10, Iss 2, p 195 (2022)
Since the start of the SARS-CoV-2 pandemic, refractory and relentless hypoxia as a consequence of exuberant lung inflammation and parenchymal damage remains the main cause of death. We have earlier reported results of the addition of dapsone in this
Externí odkaz:
https://doaj.org/article/e0104b5da390449392ddce55bc7a90cc
Publikováno v:
Cells, Vol 10, Iss 5, p 1148 (2021)
Background: Pharmacological targeting aberrant activation of epidermal growth factor receptor tyrosine kinase signaling is an established approach to treating lung adenocarcinoma. Osimertinib is a tyrosine kinase approved and effective in treating lu
Externí odkaz:
https://doaj.org/article/9c8a3a0958b14ca2a44494a6d47e845e