Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Richard E. Johnsson"'
Autor:
Melissa A. Graewert, Maria Volkova, Klara Jonasson, Juha A. E. Määttä, Tobias Gräwert, Samara Mamidi, Natalia Kulesskaya, Johan Evenäs, Richard E. Johnsson, Dmitri Svergun, Arnab Bhattacharjee, Henri J. Huttunen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Cerebral dopamine neurotrophic factor (CDNF) is an unconventional neurotrophic factor that is a disease-modifying drug candidate for Parkinson’s disease. CDNF has pleiotropic protective effects on stressed cells, but its mechanism of actio
Externí odkaz:
https://doaj.org/article/96e49cedbeaa44d2becdda52aada34c8
Autor:
Tiago Bozzola, Mariafrancesca Scalise, Christer U. Larsson, Michael C. Newton-Vesty, Caterina Rovegno, Ankita Mitra, Jonathan Cramer, Weixiao Yuan Wahlgren, Partha Radhakrishnan Santhakumari, Richard E. Johnsson, Oliver Schwardt, Beat Ernst, Rosmarie Friemann, Renwick C. J. Dobson, Cesare Indiveri, Jenny Schelin, Ulf J. Nilsson, Ulf Ellervik
Publikováno v:
ACS Chemical Biology. 17:1890-1900
Antibiotic resistance is a major worldwide concern, and new drugs with mechanistically novel modes of action are urgently needed. Here, we report the structure-based drug design, synthesis, and evaluation in vitro and in cellular systems of sialic ac
Publikováno v:
ChemMedChem. 17
In search for novel antibacterial compounds, bacterial sialic acid uptake inhibition represents a promising strategy. Sialic acid plays a critical role for growth and colonisation of several pathogenic bacteria, and its uptake inhibition in bacteria
Autor:
Fredrik R. Zetterberg, Alison MacKinnon, Thomas Brimert, Lise Gravelle, Richard E. Johnsson, Barbro Kahl-Knutson, Hakon Leffler, Ulf J. Nilsson, Anders Pedersen, Kristoffer Peterson, James A. Roper, Hans Schambye, Robert J. Slack, Susan Tantawi
Publikováno v:
Journal of medicinal chemistry. 65(19)
Galectin-3 is a carbohydrate-binding protein central to regulating mechanisms of diseases such as fibrosis, cancer, metabolic, inflammatory, and heart disease. We recently found a high affinity (nM) thiodigalactoside GB0139 which currently is in clin