Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Richard E. Baker"'
Autor:
Siddharth Subramaniyam, Michael A. DeJesus, Anisha Zaveri, Clare M. Smith, Richard E. Baker, Sabine Ehrt, Dirk Schnappinger, Christopher M. Sassetti, Thomas R. Ioerger
Publikováno v:
BMC Bioinformatics, Vol 20, Iss 1, Pp 1-15 (2019)
Abstract Background Deep sequencing of transposon mutant libraries (or TnSeq) is a powerful method for probing essentiality of genomic loci under different environmental conditions. Various analytical methods have been described for identifying condi
Externí odkaz:
https://doaj.org/article/c80d20f8c434430692d7e045fc78bfc1
Distinct Bacterial Pathways Influence the Efficacy of Antibiotics against Mycobacterium tuberculosis
Autor:
Michelle M. Bellerose, Megan K. Proulx, Clare M. Smith, Richard E. Baker, Thomas R. Ioerger, Christopher M. Sassetti
Publikováno v:
mSystems, Vol 5, Iss 4 (2020)
ABSTRACT Effective tuberculosis treatment requires at least 6 months of combination therapy. Alterations in the physiological state of the bacterium during infection are thought to reduce drug efficacy and prolong the necessary treatment period, but
Externí odkaz:
https://doaj.org/article/23c0875585844471b522ef08ddde1029
Autor:
Clare M. Smith, Megan K. Proulx, Rocky Lai, Michael C. Kiritsy, Timothy A. Bell, Pablo Hock, Fernando Pardo-Manuel de Villena, Martin T. Ferris, Richard E. Baker, Samuel M. Behar, Christopher M. Sassetti
Publikováno v:
mBio, Vol 10, Iss 6 (2019)
ABSTRACT Host genetics plays an important role in determining the outcome of Mycobacterium tuberculosis infection. We previously found that Collaborative Cross (CC) mouse strains differ in their susceptibility to M. tuberculosis and that the CC042/Ge
Externí odkaz:
https://doaj.org/article/d4cab79506754b9ea4ff592ecc872668
Autor:
Michelle M. Bellerose, Seung-Hun Baek, Chuan-Chin Huang, Caitlin E. Moss, Eun-Ik Koh, Megan K. Proulx, Clare M. Smith, Richard E. Baker, Jong Seok Lee, Seokyong Eum, Sung Jae Shin, Sang-Nae Cho, Megan Murray, Christopher M. Sassetti
Publikováno v:
mBio, Vol 10, Iss 4 (2019)
ABSTRACT Despite the administration of multiple drugs that are highly effective in vitro, tuberculosis (TB) treatment requires prolonged drug administration and is confounded by the emergence of drug-resistant strains. To understand the mechanisms th
Externí odkaz:
https://doaj.org/article/8c96fac07b8d44018a07451d69e95d7a
Autor:
Kentaro Ohkuni, Nagesh Pasupala, Jennifer Peek, Grace Lauren Holloway, Gloria D. Sclar, Reuben Levy-Myers, Richard E. Baker, Munira A. Basrai, Oliver Kerscher
Publikováno v:
Frontiers in Genetics, Vol 9 (2018)
Cell viability and gene expression profiles are altered in cellular models of neurodegenerative disorders such as Huntington’s Disease (HD). Using the yeast model system, we show that the SUMO-targeted ubiquitin ligase (STUbL) Slx5 reduces the toxi
Externí odkaz:
https://doaj.org/article/3bc68a8c17d340b5ad33f25c6dff5792
Autor:
Jill M. Perreira, Aaron M. Aker, George Savidis, Christopher R. Chin, William M. McDougall, Jocelyn M. Portmann, Paul Meraner, Miles C. Smith, Motiur Rahman, Richard E. Baker, Annick Gauthier, Michael Franti, Abraham L. Brass
Publikováno v:
Cell Reports, Vol 12, Iss 5, Pp 850-863 (2015)
Human rhinovirus (HRV) causes upper respiratory infections and asthma exacerbations. We screened multiple orthologous RNAi reagents and identified host proteins that modulate HRV replication. Here, we show that RNASEK, a transmembrane protein, was ne
Externí odkaz:
https://doaj.org/article/977d31dbe9f04844b4a20adacce40747
Autor:
Jian Zhu, Teresa Davoli, Jill M. Perriera, Christopher R. Chin, Gaurav D. Gaiha, Sinu P. John, Frederic D. Sigiollot, Geng Gao, Qikai Xu, Hongjing Qu, Thomas Pertel, Jennifer S. Sims, Jennifer A. Smith, Richard E. Baker, Louise Maranda, Aylwin Ng, Stephen J. Elledge, Abraham L. Brass
Publikováno v:
Cell Reports, Vol 9, Iss 2, Pp 752-766 (2014)
RNAi screens have implicated hundreds of host proteins as HIV-1 dependency factors (HDFs). While informative, these early studies overlap poorly due to false positives and false negatives. To ameliorate these issues, we combined information from the
Externí odkaz:
https://doaj.org/article/b80c3f7209634aecb2d5e9756a0d87f6
Autor:
Clare M. Smith, Megan K. Proulx, Andrew J. Olive, Dominick Laddy, Bibhuti B. Mishra, Caitlin Moss, Nuria Martinez Gutierrez, Michelle M. Bellerose, Palmira Barreira-Silva, Jia Yao Phuah, Richard E. Baker, Samuel M. Behar, Hardy Kornfeld, Thomas G. Evans, Gillian Beamer, Christopher M. Sassetti
Publikováno v:
mBio, Vol 7, Iss 5 (2016)
ABSTRACT The outcome of Mycobacterium tuberculosis infection and the immunological response to the bacillus Calmette-Guerin (BCG) vaccine are highly variable in humans. Deciphering the relative importance of host genetics, environment, and vaccine pr
Externí odkaz:
https://doaj.org/article/f64389b5049e4b54bef00318049e02af
Publikováno v:
mBio, Vol 5, Iss 4 (2014)
ABSTRACT Rapid growth in deep tissue is essential to the high virulence of Yersinia pestis, causative agent of plague. To better understand the mechanisms underlying this unusual ability, we used transposon mutagenesis and high-throughput sequencing
Externí odkaz:
https://doaj.org/article/669f11aa0a76439dbf5546c1a1894602
Autor:
Sherry L Kurtz, Richard E Baker, Frederick J Boehm, Chelsea C Lehman, Lara R Mittereder, Hamda Khan, Amy P Rossi, Daniel M Gatti, Gillian Beamer, Christopher M Sassetti, Karen L Elkins
Publikováno v:
PLoS Pathogens, Vol 20, Iss 3, p e1012069 (2024)
Mycobacterium tuberculosis (M.tb.) infection leads to over 1.5 million deaths annually, despite widespread vaccination with BCG at birth. Causes for the ongoing tuberculosis endemic are complex and include the failure of BCG to protect many against p
Externí odkaz:
https://doaj.org/article/9c187474d19c4dabbe2e763936c269ab