Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Richard E Rathmell"'
Autor:
Srinivasan Chandrasekhar, Bradley Condon, Matthew Allen Schiffler, Kuklish Steven Lee, Kim Euibong Jemes, Bryan H. Norman, John R. Rizzo, Jeremy Schulenburg York, Kristina M. Campanale, Stefan Jon Thibodeaux, Richard E. Rathmell, Michael J. Hickey, Christopher Groshong, Shobha N. Bhattachar, Norman Earle Hughes, Anita K. Harvey, John G. Luz, Stephen Antonysamy, Scott Alan Jones, Timothy Andrew Woods, Prashant V. Desai, Matthew J. Fisher, Xiao-Peng Yu, Thomas W. Seng
Publikováno v:
Journal of Medicinal Chemistry. 59:194-205
As part of a program aimed at the discovery of antinociceptive therapy for inflammatory conditions, a screening hit was found to inhibit microsomal prostaglandin E synthase-1 (mPGES-1) with an IC50 of 17.4 μM. Structural information was used to impr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56fa147abbccd68e15b02f28a0c1735a
https://doi.org/10.1021/acs.jmedchem.5b01249
https://doi.org/10.1021/acs.jmedchem.5b01249
Autor:
RG Simmonds, Boot, Peter Thaddeus Gallagher, Simon James Richards, Louise Wallace, G Brace, Stephen N. Mitchell, Jeremy Findlay, Nancy Dezutter, S Mahadevan, I Hoes, CL Delatour, John Fairhurst, Richard E. Rathmell, Maria Ann Whatton
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:5395-5399
A series of benzothienyloxy propylamines have been prepared and are demonstrated to be inhibitors of both serotonin and norepinephrine reuptake.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd335c766315379318b9723e2c963fec
https://doi.org/10.1016/j.bmcl.2004.08.005
https://doi.org/10.1016/j.bmcl.2004.08.005
Publikováno v:
Synthetic Communications. 30:3833-3847
A convenient and efficient method for the preparation of unsymmetrical and symmetrical diacetylenic ketones bearing a carboxylate group.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4880a7bcc0ce690c8e98cee49868e49a
https://doi.org/10.1080/00397910008086940
https://doi.org/10.1080/00397910008086940
Publikováno v:
Tetrahedron Letters. 38:7617-7620
Cyclization of α-amino-organolithiums onto unactivated alkenes results in the formation of 2,4-disubstituted pyrrolidines with high selectivities in favour of the cis isomers. The use of the α-methylbenzyl chiral auxiliary on the nitrogen atom give
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d4b437310d3537f291777dcb29dacf5
https://doi.org/10.1016/s0040-4039(97)01808-x
https://doi.org/10.1016/s0040-4039(97)01808-x
Publikováno v:
Tetrahedron Letters. 38:7621-7624
α-Amino-methylstannanes with pendent allylic ether, alkyne or carboxylic groups, can be converted, on treatment with butyllithium, to 3-vinyl-, 3-methylene- or 3-keto-pyrrolidines by anionic cyclization. © 1997 Elsevier Science Ltd.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a268248d6720e7c5d599b2cde8f0dac2
https://doi.org/10.1016/s0040-4039(97)01809-1
https://doi.org/10.1016/s0040-4039(97)01809-1
Publikováno v:
Tetrahedron Letters. 36:3557-3560
A one-pot, two-step synthesis of unsaturated piperidines from 2-keto aziridines is reported, Treatment of a range of 2-keto aziridines with two equivalents of a phosphonium ylide generates intermediate vinyl aziridines which rearrange by a [2,3]-sigm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54026cfb1480a13a97ce0d1b52aa7f18
https://doi.org/10.1016/0040-4039(95)00557-s
https://doi.org/10.1016/0040-4039(95)00557-s
Publikováno v:
J. Chem. Soc., Perkin Trans. 1. :2739-2745
A number of routes to 2-vinylaziridines are reported. N-Alkylation of a range of 2-benzoyl-3-alkylaziridines with tert-butyl bromoacetate followed by Wittig olefination gave directly a range of 4-phenylpiperidines. The intermediate 2-vinylaziridines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe30c30a4adc8eb3efffc5172f1e981a
https://doi.org/10.1039/p19950002739
https://doi.org/10.1039/p19950002739
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 1. :2906-2908
Alkynyl substituted pyrimidines and pyrazoles have been synthesized by cyclocondensations of diacetylenic ketones with amidines and hydrazines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f332c34f5201137e9ca4dc0266722167
https://doi.org/10.1039/b108645f
https://doi.org/10.1039/b108645f
Publikováno v:
ChemInform. 26
A one-pot, two-step synthesis of unsaturated piperidines from 2-keto aziridines is reported, Treatment of a range of 2-keto aziridines with two equivalents of a phosphonium ylide generates intermediate vinyl aziridines which rearrange by a [2,3]-sigm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6cc2998857fa39837d7cb534bb7a419a
https://doi.org/10.1002/chin.199536171
https://doi.org/10.1002/chin.199536171
Publikováno v:
ChemInform. 27
A number of routes to 2-vinylaziridines are reported. N-Alkylation of a range of 2-benzoyl-3-alkylaziridines with tert-butyl bromoacetate followed by Wittig olefination gave directly a range of 4-phenylpiperidines. The intermediate 2-vinylaziridines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6dc584264f95c2484e1e166e0596ff19
https://doi.org/10.1002/chin.199609148
https://doi.org/10.1002/chin.199609148