Zobrazeno 1 - 10
of 295
pro vyhledávání: '"Richard E Mains"'
Publikováno v:
PLoS Biology, Vol 17, Iss 12, p e3000566 (2019)
Peptide-based intercellular communication is a ubiquitous and ancient process that predates evolution of the nervous system. Cilia are essential signaling centers that both receive information from the environment and secrete bioactive extracellular
Externí odkaz:
https://doaj.org/article/4b8474a6286c4c6ca888d79f0b32b779
Autor:
Dhivya Kumar, Daniela Strenkert, Ramila S Patel-King, Michael T Leonard, Sabeeha S Merchant, Richard E Mains, Stephen M King, Betty A Eipper
Publikováno v:
eLife, Vol 6 (2017)
The pathways controlling cilium biogenesis in different cell types have not been fully elucidated. We recently identified peptidylglycine α-amidating monooxygenase (PAM), an enzyme required for generating amidated bioactive signaling peptides, in Ch
Externí odkaz:
https://doaj.org/article/2f90b2d4915f465aaa13b927be8c931a
Publikováno v:
Frontiers in Endocrinology, Vol 4 (2013)
In the regulated secretory pathway, secretory granules (SGs) store peptide hormones that are released on demand. SGs are formed at the trans-Golgi network (TGN) and must undergo a maturation process to become responsive to secretagogues. The producti
Externí odkaz:
https://doaj.org/article/7d8386dd610f420bbaa95f2570c3a4f9
Publikováno v:
Frontiers in Genetics, Vol 3 (2012)
Neurons modulate gene expression with subcellular precision through excitation-coupled local protein synthesis, a process that is regulated in part through the involvement of microRNAs (miRNAs), a class of small noncoding RNAs. The biosynthesis of mi
Externí odkaz:
https://doaj.org/article/cea736c19b1a49aeb648e39780e6feeb
Autor:
Ping Yin, Danielle Bousquet-Moore, Suresh P Annangudi, Bruce R Southey, Richard E Mains, Betty A Eipper, Jonathan V Sweedler
Publikováno v:
PLoS ONE, Vol 6, Iss 12, p e28679 (2011)
Amidated neuropeptides play essential roles throughout the nervous and endocrine systems. Mice lacking peptidylglycine α-amidating monooxygenase (PAM), the only enzyme capable of producing amidated peptides, are not viable. In the amidation reaction
Externí odkaz:
https://doaj.org/article/6d963a98715d451395b3eeaf41f35284
Structure of the Sec14 domain of Kalirin reveals a distinct class of lipid-binding module in RhoGEFs
Autor:
Yunfeng Li, Yulia Pustovalova, Tzanko I. Doukov, Jeffrey C. Hoch, Richard E. Mains, Betty A. Eipper, Bing Hao
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
A subset of Sec14 domain proteins use their gated hydrophobic pocket to bind and transport lipids. Here the authors provide structural and biochemical data revealing how the Sec14-fold of a Rho-GEF forms a surface groove that interacts with lysolipid
Externí odkaz:
https://doaj.org/article/80af06883c19465389b6d3b1a530d758
Autor:
Giampaolo Trivellin, Adrian F. Daly, Laura C. Hernández-Ramírez, Elisa Araldi, Christina Tatsi, Ryan K. Dale, Gus Fridell, Arjun Mittal, Fabio R. Faucz, James R. Iben, Tianwei Li, Eleonora Vitali, Stanko S. Stojilkovic, Peter Kamenicky, Chiara Villa, Bertrand Baussart, Prashant Chittiboina, Camilo Toro, William A. Gahl, Erica A. Eugster, Luciana A. Naves, Marie-Lise Jaffrain-Rea, Wouter W. de Herder, Sebastian JCMM Neggers, Patrick Petrossians, Albert Beckers, Andrea G. Lania, Richard E. Mains, Betty A. Eipper, Constantine A. Stratakis
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
IntroductionPituitary adenomas (PAs) are common, usually benign tumors of the anterior pituitary gland which, for the most part, have no known genetic cause. PAs are associated with major clinical effects due to hormonal dysregulation and tumoral imp
Externí odkaz:
https://doaj.org/article/a30ad5f4cae84c6c862ca43129169b04
Publikováno v:
British Journal of Pharmacology. 179:3306-3324
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::01bb0bfd959bfb25f64a5e4e932a9118
https://doi.org/10.1111/bph.15815
https://doi.org/10.1111/bph.15815
Autor:
Giampaolo Trivellin, Adrian F. Daly, Laura C. Hernández-Ramírez, Elisa Araldi, Christina Tatsi, Ryan K. Dale, Gus Fridell, Arjun Mittal, Fabio R. Faucz, James R. Iben, Tianwei Li, Eleonora Vitali, Stanko S. Stojilkovic, Peter Kamenicky, Chiara Villa, Bertrand Baussart, Prashant Chittiboina, Camilo Toro, William A. Gahl, Erica A. Eugster, Luciana A. Naves, Marie-Lise Jaffrain-Rea, Wouter W. de Herder, Sebastian JCMM Neggers, Patrick Petrossians, Albert Beckers, Andrea G. Lania, Richard E. Mains, Betty A. Eipper, Constantine A. Stratakis
Publikováno v:
medRxiv
Pituitary adenomas (PAs) are common, usually benign tumors of the anterior pituitary gland which, for the most part, have no known genetic cause. PAs are associated with major clinical effects due to hormonal dysregulation and tumoral impingement on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57f8050d2a30a58b9ba340adbc1ceb13
https://doi.org/10.1101/2023.01.20.23284646
https://doi.org/10.1101/2023.01.20.23284646
Publikováno v:
The FEBS Journal. 289:4470-4496
Our understanding of the ways in which peptides are used for communication in the nervous and endocrine systems began with the identification of oxytocin, vasopressin and insulin, each of which is stored in electron dense granules, ready for release
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bb9676bcf788c1828a66bf684b1d61b
https://doi.org/10.1111/febs.16049
https://doi.org/10.1111/febs.16049