Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Richard E Loiacono"'
Autor:
Peta Burns, Anthony L. Albiston, Joshua Bowditch, Vi Pham, Richard E Loiacono, James McFadyen, Siew Yeen Chai
Publikováno v:
Behavioural Brain Research. 376:112150
Oxytocin, and the closely related neuropeptide, vasopressin, are both known to modulate social behaviours. The pro-social effects of oxytocin are well-documented and have generated much interest into its suitability as a therapeutic for disorders cha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1874f8d6ae5b24741d42f4622e690b88
https://doi.org/10.1016/j.bbr.2019.112150
https://doi.org/10.1016/j.bbr.2019.112150
Autor:
Katie Leach, Arthur Christopoulos, S Suratman, Christian C. Felder, Richard E Loiacono, Patrick M. Sexton
Publikováno v:
British Journal of Pharmacology. 162:1659-1670
BACKGROUND AND PURPOSE We recently characterized LY2033298 as a novel allosteric modulator and agonist at M4 muscarinic acetylcholine receptors (mAChRs). Evidence also suggested a difference in the potency of LY2033298 at rodent relative to human M4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5951c19181ddf89889f60084ebdaa056
https://doi.org/10.1111/j.1476-5381.2010.01184.x
https://doi.org/10.1111/j.1476-5381.2010.01184.x
Autor:
Daniel Thomas Malone, Stephanie Ann Robinson, Patrick M. Sexton, Richard E Loiacono, Arthur Christopoulos
Publikováno v:
Brain Research. 1343:153-167
Rearing rats in single cages from weaning until adulthood (social isolation) produces a number of behavioral and neurochemical alterations similar to those observed in psychoses such as schizophrenia. Also, a dysregulation of the endocannabinoid syst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6440fd9d8416f9618e74bdfe6dfeab1
https://doi.org/10.1016/j.brainres.2010.04.031
https://doi.org/10.1016/j.brainres.2010.04.031
Publikováno v:
British Journal of Pharmacology. 154:584-597
Athletes attempt to improve performance with drugs that act on the β-adrenergic system directly or indirectly. Of three β-adrenoceptor (AR) subtypes, the β2-AR is the main target in sport; they have bronchodilator and anabolic actions and enhance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ab1fc8a04110e6081623030f9373a28
https://doi.org/10.1038/bjp.2008.164
https://doi.org/10.1038/bjp.2008.164
Autor:
David H. Small, Judy Ng, Sharon Unabia, Danuta Maksel, Megan L. Kerr, Mary Chebib, Marie-Isabel Aguilar, Richard E Loiacono, Cindy Chu, Michael F. Azari, Hossein Mehrani, Xu Hou
Publikováno v:
Journal of Neurochemistry. 101:1527-1538
Accumulation of the amyloid protein (Abeta) in the brain is an important step in the pathogenesis of Alzheimer's disease. However, the mechanism by which Abeta exerts its neurotoxic effect is largely unknown. It has been suggested that the peptide ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ae50263d949aa845396769bd59b9e24
https://doi.org/10.1111/j.1471-4159.2006.04444.x
https://doi.org/10.1111/j.1471-4159.2006.04444.x
Publikováno v:
Journal of Neurochemistry. 64:2057-2063
N-Methyl-D-aspartate (NMDA) receptors regulating the release of [ 3 H]noradrenaline ([ 3 H]NA) and D-[ 3 H]aspartate (D-[ 3 H]Asp) were investigated in superfused slices of rat hippocampus in the presence and absence of nitrergic drugs to examine a p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c11bc9af33f31a0248f3c4f2d4ff67c
https://doi.org/10.1046/j.1471-4159.1995.64052057.x
https://doi.org/10.1046/j.1471-4159.1995.64052057.x
Publikováno v:
British Journal of Pharmacology. 132:1650-1656
The present study examined the effect of a range of doses of chronic nicotine (0.75, 1.5, 3.0 and 30.0 mg kg(-1) day(-1), s.c., 14 days) upon striatal dopaminergic nerve terminal survival following 6-hydroxydopamine (6-OHDA; 10 microg intrastriatal u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::904ff3d9acc9435ace48c525b2e029a2
https://doi.org/10.1038/sj.bjp.0703989
https://doi.org/10.1038/sj.bjp.0703989
Autor:
Richard E Loiacono, Rebecca Ryan
Publikováno v:
Neuroreport. 12:569-572
Recent evidence suggests that alpha7 subunit-containing nicotinic receptors (nAChRs) within the ventral tegmental area (VTA) are involved in the processes underlying nicotine tolerance and withdrawal. The current study used in situ hybridization hist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c09ad561141beedd208a0a200c394fe3
https://doi.org/10.1097/00001756-200103050-00027
https://doi.org/10.1097/00001756-200103050-00027
Publikováno v:
European Journal of Pharmacology. 315:11-18
Central administration of the N-type Ca2+ channel blocker omega-conotoxin GVIA in conscious rabbits has previously been shown to result in a slowly developing hypotensive and sympatholytic effect, with peak changes observed after 48 h. The aim of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2e4d3076e56cd185382c6f70cc5731d
https://doi.org/10.1016/s0014-2999(96)00592-4
https://doi.org/10.1016/s0014-2999(96)00592-4
Publikováno v:
Neuropharmacology. 32:847-853
The displacement of [3H](−)-nicotine from its binding site in rat cerebral cortex by a number of antagonists was investigated. [3H](−)-Nicotine appeared to bind to a single site with a dissociation constant (KD) of 5.5 nM; pancuronium, gallamine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c8036b55c231d44bdb87719f74f5465
https://doi.org/10.1016/0028-3908(93)90139-t
https://doi.org/10.1016/0028-3908(93)90139-t