Zobrazeno 1 - 10
of 269
pro vyhledávání: '"Richard E Frye"'
Autor:
Sophie Charrasse, Victor Racine, Charlotte Saint-Omer, Titouan Poquillon, Loïc Lionnard, Marine Ledru, Christophe Gonindard, Sandrine Delaunois, Karima Kissa, Richard E Frye, Manuela Pastore, Christelle Reynes, Mathilde Frechet, Hanane Chajra, Abdel Aouacheria
Publikováno v:
PLoS ONE, Vol 19, Iss 3, p e0301372 (2024)
The importance of mitochondria in tissue homeostasis, stress responses and human diseases, combined to their ability to transition between various structural and functional states, makes them excellent organelles for monitoring cell health. There is
Externí odkaz:
https://doaj.org/article/efe87f5e2b374a2d96f8519f9e6efa71
Autor:
Shannon Rose, Richard E Frye, John Slattery, Rebecca Wynne, Marie Tippett, Oleksandra Pavliv, Stepan Melnyk, S Jill James
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e85436 (2014)
There is increasing recognition that mitochondrial dysfunction is associated with the autism spectrum disorders. However, little attention has been given to the etiology of mitochondrial dysfunction or how mitochondrial abnormalities might interact w
Externí odkaz:
https://doaj.org/article/265b65bc38d140dfbced1f60cdeaf3c3
Publikováno v:
Frontiers in Systems Neuroscience, Vol 4 (2010)
Functional neuroimaging studies suggest that neural networks that subserve reading are organized differently in dyslexic readers (DRs) and typical readers (TRs), yet the hierarchical structure of these networks has not been well studied. We used Gran
Externí odkaz:
https://doaj.org/article/9b6d68df3a934948821da7027dbb6617
Autor:
Richard E Frye
Publikováno v:
Frontiers in Neuroscience, Vol 4 (2010)
Tetrahydrobiopterin (BH4) is a naturally occurring cofactor essential for critical metabolic pathways. Studies suggest that BH4 supplementation may ameliorate autism symptoms; the biological mechanism for such an effect is unknown. To help understand
Externí odkaz:
https://doaj.org/article/4e4725ddf40f4c15adeb654d683ea022
Autor:
Sophie Charrasse, Titouan Poquillon, Charlotte Saint-Omer, Manuela Pastore, Benoit Bordignon, Richard E. Frye, Christelle Reynes, Victor Racine, Abdel Aouacheria
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 5609-5619 (2023)
Mitochondria are essential organelles that play crucial roles in cellular energy metabolism, calcium signaling and apoptosis. Their importance in tissue homeostasis and stress responses, combined to their ability to transition between various structu
Externí odkaz:
https://doaj.org/article/6e14ec44181243a2a8d9451fd078c5e5
Deciduous tooth biomarkers reveal atypical fetal inflammatory regulation in autism spectrum disorder
Autor:
Dani Dumitriu, Elena Baldwin, Roozie J.J. Coenen, Luke A. Hammond, Darcy S. Peterka, Lynne Heilbrun, Richard E. Frye, Raymond Palmer, Hjalmar Nobel Norrman, Anna Fridell, Karl Lundin Remnelius, Johan Isaksson, Christine Austin, Paul Curtin, Sven Bölte, Manish Arora
Publikováno v:
iScience, Vol 26, Iss 3, Pp 106247- (2023)
Summary: Atypical regulation of inflammation has been proposed in the etiology of autism spectrum disorder (ASD); however, measuring the temporal profile of fetal inflammation associated with future ASD diagnosis has not been possible. Here, we prese
Externí odkaz:
https://doaj.org/article/a1b8c7fd487f4a44babb43e212277506
Mitochondrial morphology is associated with respiratory chain uncoupling in autism spectrum disorder
Autor:
Richard E. Frye, Loïc Lionnard, Indrapal Singh, Mohammad A. Karim, Hanane Chajra, Mathilde Frechet, Karima Kissa, Victor Racine, Amrit Ammanamanchi, Patrick John McCarty, Leanna Delhey, Marie Tippett, Shannon Rose, Abdel Aouacheria
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract Autism spectrum disorder (ASD) is a neurodevelopmental disorder that is associated with unique changes in mitochondrial metabolism, including elevated respiration rates and morphological alterations. We examined electron transport chain (ETC
Externí odkaz:
https://doaj.org/article/16d1cc2755014f93b135086f758acd28
Autor:
Andrew W. Zimmerman, Kanwaljit Singh, Susan L. Connors, Hua Liu, Anita A. Panjwani, Li-Ching Lee, Eileen Diggins, Ann Foley, Stepan Melnyk, Indrapal N. Singh, S. Jill James, Richard E. Frye, Jed W. Fahey
Publikováno v:
Molecular Autism, Vol 12, Iss 1, Pp 1-22 (2021)
Abstract Background Sulforaphane (SF), an isothiocyanate in broccoli, has potential benefits relevant to autism spectrum disorder (ASD) through its effects on several metabolic and immunologic pathways. Previous clinical trials of oral SF demonstrate
Externí odkaz:
https://doaj.org/article/cfdd1aa8a2284064ac4e1899d7e775ee
Autor:
Kanwaljit Singh, Indrapal N. Singh, Eileen Diggins, Susan L. Connors, Mohammad A. Karim, David Lee, Andrew W. Zimmerman, Richard E. Frye
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 7, Iss 5, Pp 683-694 (2020)
Abstract Background Developmental regression (DR) occurs in about one‐third of children with Autism Spectrum Disorder (ASD) yet it is poorly understood. Current evidence suggests that mitochondrial function in not normal in many children with ASD.
Externí odkaz:
https://doaj.org/article/fe5365ba68db4c09ad79eefadc691097
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 2082 (2023)
Early diagnosis of autism spectrum disorder (ASD) is crucial for providing appropriate treatments and parental guidance from an early age. Yet, ASD diagnosis is a lengthy process, in part due to the lack of reliable biomarkers. We recently applied RN
Externí odkaz:
https://doaj.org/article/8868ab9a198249a6a5de762568a17334