Zobrazeno 1 - 10
of 182
pro vyhledávání: '"Richard E, Pratt"'
Autor:
Sonalí Harris, Iqra Anwar, Syeda S. Baksh, Richard E. Pratt, Victor J. Dzau, Conrad P. Hodgkinson
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract In a previous report, we demonstrated that Cbx1, PurB and Sp3 inhibited cardiac muscle differentiation by increasing nucleosome density around cardiac muscle gene promoters. Since cardiac and skeletal muscle express many of the same proteins
Externí odkaz:
https://doaj.org/article/090c31b4b9ad4fe3b9b2138540c91f34
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 2, Pp 102160- (2024)
Reprogramming scar fibroblasts into cardiomyocytes has been proposed to reverse the damage associated with myocardial infarction. However, the limited improvement in cardiac function calls for enhanced strategies. We reported enhanced efficacy of our
Externí odkaz:
https://doaj.org/article/9c4cf1afc2cb4325b8d0a12e4c079fb9
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-8 (2023)
Abstract Current methods to generate cardiomyocytes from induced pluripotent stem cells (iPSc) utilize broad-spectrum pharmacological inhibitors. These methods give rise to cardiomyocytes which are typically immature. Since we have recently demonstra
Externí odkaz:
https://doaj.org/article/fed1b86478eb4f6da5f460e534ce8dfe
Autor:
Jiabiao Hu, Conrad P. Hodgkinson, Richard E. Pratt, JaeWoo Lee, Bruce A. Sullenger, Victor J. Dzau
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 23, Iss , Pp 55-62 (2021)
Reprogramming scar fibroblasts into new heart muscle cells has the potential to restore function to the injured heart. However, the effectiveness of reprogramming is notably low. We have recently demonstrated that the effectiveness of reprogramming f
Externí odkaz:
https://doaj.org/article/a6c63bacc4084937af5bd7c64aa9f79e
Publikováno v:
American Journal of Physiology-Cell Physiology. 324:C843-C855
We discovered that innate immunity plays an important role in the reprogramming of fibroblasts into cardiomyocytes. In this report, we define the role of a novel retinoic acid-inducible gene 1 Yin Yang 1 (Rig1:YY1) pathway. We found that fibroblast t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf689386c8e0a986b6c9451234b894e6
https://doi.org/10.1152/ajpcell.00402.2022
https://doi.org/10.1152/ajpcell.00402.2022
Neonatal and adult cardiac fibroblasts exhibit inherent differences in cardiac regenerative capacity
Publikováno v:
Journal of Biological Chemistry. 299:104694
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b50bc8368602d8ba28786f6bdb51057f
https://doi.org/10.1016/j.jbc.2023.104694
https://doi.org/10.1016/j.jbc.2023.104694
Publikováno v:
American Journal of Physiology-Cell Physiology. 319:C1141-C1150
Stem cell injections are an attractive therapeutic tool. It has been demonstrated that injected stem cells promote tissue repair and regeneration via paracrine mechanisms. However, the effects of injected stem cells continue for far longer than they
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c082c54b1a398831be96f5ea432ca049
https://doi.org/10.1152/ajpcell.00516.2019
https://doi.org/10.1152/ajpcell.00516.2019
Publikováno v:
SSRN Electronic Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb10972fa1fc641abc6b3c4453996550
https://doi.org/10.2139/ssrn.4279247
https://doi.org/10.2139/ssrn.4279247
Publikováno v:
Circulation. 144
We, and others, have demonstrated that directly reprogramming scar fibroblasts into new cardiomyocytes improves cardiac function in the infarcted heart. A major challenge is the specific delivery of reprogramming factors to cardiac fibroblasts in viv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::63e1fed1794b881333a9eb6a448ee251
https://doi.org/10.1161/circ.144.suppl_1.9745
https://doi.org/10.1161/circ.144.suppl_1.9745
Publikováno v:
Circulation. 144
There is considerable interest in regenerating the injured heart by reprogramming resident fibroblasts into new functional cardiomyocytes. Cardiac reprogramming has been achieved via transcription factors or miRNAs. Transcription factor combinations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2fdf2863047dfc58f8f9b0a844b5ab82
https://doi.org/10.1161/circ.144.suppl_1.9742
https://doi.org/10.1161/circ.144.suppl_1.9742