Zobrazeno 1 - 10
of 1 323
pro vyhledávání: '"Richard E, Lee"'
Autor:
Daniel C. Scott, Suresh Dharuman, Elizabeth Griffith, Sergio C. Chai, Jarrid Ronnebaum, Moeko T. King, Rajendra Tangallapally, Chan Lee, Clifford T. Gee, Lei Yang, Yong Li, Victoria C. Loudon, Ha Won Lee, Jason Ochoada, Darcie J. Miller, Thilina Jayasinghe, Joao A. Paulo, Stephen J. Elledge, J. Wade Harper, Taosheng Chen, Richard E. Lee, Brenda A. Schulman
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract PROTAC® (proteolysis-targeting chimera) molecules induce proximity between an E3 ligase and protein-of-interest (POI) to target the POI for ubiquitin-mediated degradation. Cooperative E3-PROTAC-POI complexes have potential to achieve neo-su
Externí odkaz:
https://doaj.org/article/6c50c513c918469eaf4c94f0f0e0d58b
Publikováno v:
Contemporary Sociology, 2011 Nov 01. 40(6), 779-780.
Externí odkaz:
https://www.jstor.org/stable/23042521
Autor:
Yue Zhou, Gregory A. Phelps, Mikayla M. Mangrum, Jemma McLeish, Elise K. Phillips, Jinchao Lou, Christelle F. Ancajas, Jeffrey M. Rybak, Peter M. Oelkers, Richard E. Lee, Michael D. Best, Todd B. Reynolds
Publikováno v:
mBio, Vol 15, Iss 5 (2024)
ABSTRACTSystemic infections by Candida spp. are associated with high mortality rates, partly due to limitations in current antifungals, highlighting the need for novel drugs and drug targets. The fungal phosphatidylserine synthase, Cho1, from Candida
Externí odkaz:
https://doaj.org/article/78c37e13beb64762ba0868b9367af010
Autor:
Dmitry Leshchiner, Federico Rosconi, Bharathi Sundaresh, Emily Rudmann, Luisa Maria Nieto Ramirez, Andrew T. Nishimoto, Stephen J. Wood, Bimal Jana, Noemí Buján, Kaicheng Li, Jianmin Gao, Matthew Frank, Stephanie M. Reeve, Richard E. Lee, Charles O. Rock, Jason W. Rosch, Tim van Opijnen
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
A lack of understanding in the development and emergence of antimicrobial resistance presents as a problem for accurate infection diagnosis and treatment. Here, authors utilize Streptococcus pneumoniae and build a genome-wide atlas to understand the
Externí odkaz:
https://doaj.org/article/79f7f04a405b4d6d8aab8145e4e451c5
Autor:
Giridhar Sekar, Geetika Singh, Xingping Qin, Cristina D. Guibao, Brittany Schwam, Zintis Inde, Christy R. Grace, Weixing Zhang, P. Jake Slavish, Wenwei Lin, Taosheng Chen, Richard E. Lee, Zoran Rankovic, Kristopher Sarosiek, Tudor Moldoveanu
Publikováno v:
iScience, Vol 25, Iss 10, Pp 105064- (2022)
Summary: Poration of the outer mitochondrial membrane by the effector BCL-2 proteins BAK and BAX initiates apoptosis. BH3-only initiators BID and BIM trigger conformational changes in BAK and BAX transforming them from globular dormant proteins to ol
Externí odkaz:
https://doaj.org/article/fc870169a2a5437db2f83180dfe88295
Autor:
Keyur R. Parmar, Pradeep B. Lukka, Santosh Wagh, Zaid H. Temrikar, Jiuyu Liu, Richard E. Lee, Miriam Braunstein, Anthony J. Hickey, Gregory T. Robertson, Mercedes Gonzalez-Juarrero, Andrea Edginton, Bernd Meibohm
Publikováno v:
Pharmaceutics, Vol 15, Iss 6, p 1759 (2023)
Spectinamides 1599 and 1810 are lead spectinamide compounds currently under preclinical development to treat multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis. These compounds have previously been tested at various combinati
Externí odkaz:
https://doaj.org/article/e146c5c3fef646658561f95712d507a4
Autor:
Marshall, J
http://epress.lib.uts.edu.au/journals/index.php/csrj/article/viewFile/2307/2498 Compares World Systems Theory with Disorder theory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______363::58617eaa73f5b7f73480ced2988cd195
https://hdl.handle.net/10453/126499
https://hdl.handle.net/10453/126499
Autor:
Richard E. Lee
In his pathbreaking article'History and the Social Sciences: The Longue Durée,'Fernand Braudel raised a call for the social sciences to overcome their disciplinary isolation from one another. Commemorating the fiftieth anniversary of the article's p
Autor:
Seung Wook Yang, Xin Huang, Wenwei Lin, Jaeki Min, Darcie J. Miller, Anand Mayasundari, Patrick Rodrigues, Elizabeth C. Griffith, Clifford T. Gee, Lei Li, Wei Li, Richard E. Lee, Zoran Rankovic, Taosheng Chen, Patrick Ryan Potts
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Testis-restricted melanoma antigen (MAGE) proteins function as substrate adapters for E3 ubiquitin ligases. Biochemical and structural analyses of MAGE-A11 provide insight into the substrate binding mode of MAGE proteins and enable discovery of poten
Externí odkaz:
https://doaj.org/article/b277e39e14d144a186f5155bc60329ef
Autor:
Richard E. Lee
During the last few decades, the fundamental premises of the modern view of knowledge have been increasingly called into question. Questioning Nineteenth-Century Assumptions about Knowledge III: Dualism provides an in-depth look at the debates surrou