Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Richard Dima"'
Autor:
Hassal Lee, Alexander Shakeel Bates, Richard Dima, Sandeep Nadella, Nicole Jordan-Martin, Christina Brennan, Tobias Janowitz
Publikováno v:
Cancer Research. 82:A050-A050
The current under-representation of racial and ethnic minorities and socio-economically disadvantaged participants in clinical trials represents an important problem, because it reduces generalizability of trial results and should urgently be address
Autor:
Seun Akindehin, Arkadiusz Liskiewicz, Daniela Liskiewicz, Miriam Bernecker, Cristina Garcia-Caceres, Daniel J. Drucker, Brian Finan, Gerald Grandl, Robert Gutgesell, Susanna M. Hofmann, Ahmed Khalil, Xue Liu, Perla Cota, Mostafa Bakhti, Oliver Czarnecki, Aimée Bastidas-Ponce, Heiko Lickert, Lingru Kang, Gandhari Maity, Aaron Novikoff, Sebastian Parlee, Ekta Pathak, Sonja C. Schriever, Michael Sterr, Siegfried Ussar, Qian Zhang, Richard DiMarchi, Matthias H. Tschöp, Paul T. Pfluger, Jonathan D. Douros, Timo D. Müller
Publikováno v:
Molecular Metabolism, Vol 83, Iss , Pp 101915- (2024)
Objective: The glucose-dependent insulinotropic polypeptide (GIP) decreases body weight via central GIP receptor (GIPR) signaling, but the underlying mechanisms remain largely unknown. Here, we assessed whether GIP regulates body weight and glucose c
Externí odkaz:
https://doaj.org/article/4df457ac59ce49e8af09680efdd590e2
Autor:
Martina Chrudinová, Nicholas S. Kirk, Aurelien Chuard, Hari Venugopal, Fa Zhang, Marta Lubos, Vasily Gelfanov, Terezie Páníková, Lenka Žáková, Julianne Cutone, Matthew Mojares, Richard DiMarchi, Jiří Jiráček, Emrah Altindis
Publikováno v:
Molecular Metabolism, Vol 80, Iss , Pp 101863- (2024)
Objective: The insulin/IGF superfamily is conserved across vertebrates and invertebrates. Our team has identified five viruses containing genes encoding viral insulin/IGF-1 like peptides (VILPs) closely resembling human insulin and IGF-1. This study
Externí odkaz:
https://doaj.org/article/7c5f60a2f83f44fdb26861620a039b02
Publikováno v:
Journal of Clinical Oncology. 38:e14089-e14089
e14089 Background: Selecting the right clinical trials for patients remains a challenging job. The better the match between a clinical trial and the target patient population before conducting a study, the more likely the study will successfully reac
Autor:
Aaron Novikoff, Shannon L. O'Brien, Miriam Bernecker, Gerald Grandl, Maximilian Kleinert, Patrick J. Knerr, Kerstin Stemmer, Martin Klingenspor, Anja Zeigerer, Richard DiMarchi, Matthias H. Tschöp, Brian Finan, Davide Calebiro, Timo D. Müller
Publikováno v:
Molecular Metabolism, Vol 49, Iss , Pp 101181- (2021)
Objective: We assessed the spatiotemporal GLP-1 and GIP receptor signaling, trafficking, and recycling dynamics of GIPR mono-agonists, GLP-1R mono-agonists including semaglutide, and GLP-1/GIP dual-agonists MAR709 and tirzepatide. Methods: Receptor G
Externí odkaz:
https://doaj.org/article/3747ffadfcfc4ababd52d92c0564e71b
Autor:
Belen Rivero-Gutierrez, April Haller, Jenna Holland, Emily Yates, Radha Khrisna, Kirk Habegger, Richard Dimarchi, David D'Alessio, Diego Perez-Tilve
Publikováno v:
Molecular Metabolism, Vol 17, Iss , Pp 28-38 (2018)
Objective: Mice with congenital loss of the glucagon receptor gene (Gcgr−/− mice) remain normoglycemic in insulinopenic conditions, suggesting that unopposed glucagon action is the driving force for hyperglycemia in Type-1 Diabetes Mellitus (T1DM
Externí odkaz:
https://doaj.org/article/ad4c8df431c547afbdea34e422f6c6ea
Autor:
Shelly R. Nason, Jessica Antipenko, Natalie Presedo, Stephen E. Cunningham, Tanya H. Pierre, Teayoun Kim, Jodi R. Paul, Cassie Holleman, Martin E. Young, Karen L. Gamble, Brian Finan, Richard DiMarchi, Chad S. Hunter, Alexei Kharitonenkov, Kirk M. Habegger
Publikováno v:
JCI Insight, Vol 6, Iss 4 (2021)
Glucagon regulates glucose and lipid metabolism and promotes weight loss. Thus, therapeutics stimulating glucagon receptor (GCGR) signaling are promising for obesity treatment; however, the underlying mechanism(s) have yet to be fully elucidated. We
Externí odkaz:
https://doaj.org/article/e8dcffeaedd84dd1a4aa5ab2124d4f0a
Autor:
Shilpak Bele, Shravan Babu Girada, Aramita Ray, Abhishek Gupta, Srinivas Oruganti, Phanithi Prakash Babu, Rahul SR Rayalla, Shashi Vardhan Kalivendi, Ahamed Ibrahim, Vishwajeet Puri, Venkateswar Adalla, Madhumohan R Katika, Richard DiMarchi, Prasenjit Mitra
Publikováno v:
eLife, Vol 9 (2020)
Given its glycemic efficacy and ability to reduce the body weight, glucagon-like peptide 1 receptor (GLP-1R) agonism has emerged as a preferred treatment for diabetes associated with obesity. We here report that a small-molecule Class 1 histone deace
Externí odkaz:
https://doaj.org/article/bc7951a1758043849dd74d907661bb2c
Autor:
Simone Renner, Andreas Blutke, Britta Dobenecker, Georg Dhom, Timo D. Müller, Brian Finan, Christoffer Clemmensen, Maren Bernau, Istvan Novak, Birgit Rathkolb, Steffanie Senf, Susanne Zöls, Mirjam Roth, Anna Götz, Susanna M. Hofmann, Martin Hrabĕ de Angelis, Rüdiger Wanke, Ellen Kienzle, Armin M. Scholz, Richard DiMarchi, Mathias Ritzmann, Matthias H. Tschöp, Eckhard Wolf
Publikováno v:
Molecular Metabolism, Vol 16, Iss , Pp 180-190 (2018)
Objective: The worldwide prevalence of obesity has increased to 10% in men and 15% in women and is associated with severe comorbidities such as diabetes, cancer, and cardiovascular disease. Animal models of obesity are central to experimental studies
Externí odkaz:
https://doaj.org/article/d4b307cf77fc4936afcd250c904470f7
Autor:
Jenna Holland, Joyce Sorrell, Emily Yates, Kathleen Smith, Shahriar Arbabi, Myrtha Arnold, Marita Rivir, Rachel Morano, Jenny Chen, Xiang Zhang, Richard Dimarchi, Stephen C. Woods, Joan Sanchez-Gurmaches, Eric Wohleb, Diego Perez-Tilve
Publikováno v:
Cell Reports, Vol 27, Iss 8, Pp 2399-2410.e6 (2019)
Summary: The melanocortin system is a brain circuit that influences energy balance by regulating energy intake and expenditure. In addition, the brain-melanocortin system controls adipose tissue metabolism to optimize fuel mobilization and storage. S
Externí odkaz:
https://doaj.org/article/37f4fedec4f1438888426dda4e132b9a