Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Richard Debiasio"'
Autor:
Julio Aleman, Ravikumar K, Connor Wiegand, Mark E. Schurdak, Lawrence Vernetti, Dillon Gavlock, Celeste Reese, Richard DeBiasio, Greg LaRocca, Yulder Daniel Angarita, Albert Gough, Alejandro Soto-Gutierrez, Jaideep Behari, Vijay K. Yechoor, Mark T. Miedel, Andrew M. Stern, Ipsita Banerjee, D. Lansing Taylor
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-14 (2024)
Abstract Preclinical and clinical studies suggest that lipid-induced hepatic insulin resistance is a primary defect that predisposes to dysfunction in islets, implicating a perturbed liver-pancreas axis underlying the comorbidity of T2DM and MASLD. T
Externí odkaz:
https://doaj.org/article/3786b7dd0e8e47af8bbe42c89dff77b0
Autor:
Mengying Xia, Mahboubeh Varmazyad, Iris Pla-Palacín, Dillon C. Gavlock, Richard DeBiasio, Gregory LaRocca, Celeste Reese, Rodrigo M. Florentino, Lanuza A. P. Faccioli, Jacquelyn A. Brown, Lawrence A. Vernetti, Mark Schurdak, Andrew M. Stern, Albert Gough, Jaideep Behari, Alejandro Soto-Gutierrez, D. Lansing Taylor, Mark T. Miedel
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a worldwide health epidemic with a global occurrence of approximately 30%. The pathogenesis of MASLD is a complex, multisystem disorder driven by multiple factors, including genetics
Externí odkaz:
https://doaj.org/article/ee7744aae33d4960a923808275c298d0
Autor:
Daniel E. Lefever, Mark T. Miedel, Fen Pei, Johanna K. DiStefano, Richard Debiasio, Tong Ying Shun, Manush Saydmohammed, Maria Chikina, Lawrence A. Vernetti, Alejandro Soto-Gutierrez, Satdarshan P. Monga, Ramon Bataller, Jaideep Behari, Vijay K. Yechoor, Ivet Bahar, Albert Gough, Andrew M. Stern, D. Lansing Taylor
Publikováno v:
Metabolites, Vol 12, Iss 6, p 528 (2022)
Non-alcoholic fatty liver disease (NAFLD) has a high global prevalence with a heterogeneous and complex pathophysiology that presents barriers to traditional targeted therapeutic approaches. We describe an integrated quantitative systems pharmacology
Externí odkaz:
https://doaj.org/article/465968be7e9348c68b977f1cf547b02f
Autor:
Anupma Jha, Tong Ying Shun, Dillon C. Gavlock, Vijay Yechoor, Vineet Mahajan, Daniel E. Lefever, Xiang Li, Alejandro Soto-Gutierrez, Lawrence Vernetti, Jaideep Behari, D. Lansing Taylor, Albert Gough, Erin E. Kershaw, Celeste E. Reese, Richard DeBiasio, Manush Saydmohammed, Mark T. Miedel, Andrew M. Stern
Publikováno v:
Exp Biol Med (Maywood)
Metabolic syndrome is a complex disease that involves multiple organ systems including a critical role for the liver. Non-alcoholic fatty liver disease (NAFLD) is a key component of the metabolic syndrome and fatty liver is linked to a range of metab
Autor:
Mark T. Miedel, Anthony Saleh, Lawrence Vernetti, Richard DeBiasio, Alaa Alsebahi, Kristin M. Bircsak, Ryan Reddinger, Albert Gough, Tongying Shun
Publikováno v:
Toxicology. 450
We report the development, automation and validation of a 3D, microfluidic liver-on-a-chip for high throughput hepatotoxicity screening, the OrganoPlate LiverTox™. The model is comprised of aggregates of induced pluripotent stem cell (iPSC)-derived
Autor:
D. Lansing Taylor, Anup D. Sharma, Albert Gough, Lawrence Vernetti, Subin M. George, Felipe T. Lee-Montiel, Richard DeBiasio, Juanfang Wu
Publikováno v:
Experimental Biology and Medicine. 242:1617-1632
This article describes our next generation human Liver Acinus MicroPhysiology System (LAMPS). The key demonstration of this study was that Zone 1 and Zone 3 microenvironments can be established by controlling the oxygen tension in individual devices
Autor:
Richard DeBiasio, Albert Gough, Nina Senutovitch, Robert C. Boltz, D. Lansing Taylor, Lawrence Vernetti
Publikováno v:
Experimental Biology and Medicine. 240:795-808
This mini-review discusses the evolution of fluorescence as a tool to study living cells and tissues in vitro and the present role of fluorescent protein biosensors (FPBs) in microphysiological systems (MPSs). FPBs allow the measurement of temporal a
Autor:
William J. McCarty, Abhinav Bhushan, Tong Ying Shun, Ahmet Bakan, Rohit Jindal, Shyam Sundhar Bale, Richard DeBiasio, D. Lansing Taylor, Lawrence Vernetti, Albert Gough, Berk Osman Usta, Inna Golberg, Martin L. Yarmush, Nina Senutovitch, Manjunath Hegde
Publikováno v:
Experimental Biology and Medicine. 239:1180-1191
The liver is a heterogeneous organ with many vital functions, including metabolism of pharmaceutical drugs and is highly susceptible to injury from these substances. The etiology of drug-induced liver disease is still debated although generally regar
Autor:
D. Lansing Taylor, Anthony D. Saleh, Anup D. Sharma, Richard DeBiasio, Albert Gough, Karlijn Wilschut, Paul Vulto, Lawrence Vernetti
Publikováno v:
Drug Metabolism and Pharmacokinetics. 34:S50
A human liver microphysiology platform for investigating physiology, drug safety, and disease models
Autor:
D. Lansing Taylor, Richard DeBiasio, Lawrence Vernetti, Albert Gough, Nina Senutovitch, Tong Ying Shun, Robert C. Boltz
Publikováno v:
Experimental biology and medicine (Maywood, N.J.). 241(1)
This paper describes the development and characterization of a microphysiology platform for drug safety and efficacy in liver models of disease that includes a human, 3D, microfluidic, four-cell, sequentially layered, self-assembly liver model (SQL-S