Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Richard D. Zachman"'
Autor:
Richard D. Zachman, James Allen Olson
Publikováno v:
Journal of Lipid Research, Vol 6, Iss 1, Pp 27-32 (1965)
The isolated perfused liver was employed to study various aspects of retinol-C14 metabolism. The rate of uptake of retinol, retinal, retinoic acid, and retinol acetate was rapid (first-order rate constant, k = 0.12–0.16 min−1) during the first 3
Externí odkaz:
https://doaj.org/article/549b5e0e067b45b6bf0f242776a0303d
Autor:
Richard D. Zachman, Mary A. Grummer
Publikováno v:
Neonatology. 80:152-157
Fetal exposure to ethanol disrupts normal craniofacial development, resulting in characteristic features of fetal alcohol syndrome (FAS). One mechanism that could result in some anomalies of this syndrome is through ethanol disrupting the regulatory
Autor:
Richard D. Zachman, Mary A. Grummer
Publikováno v:
Alcoholism: Clinical and Experimental Research. 22:1544-1556
The mechanism of the fetal embryopathology resulting from ethanol ingestion during pregnancy is not established. This review summarizes recent research on the interaction of ethanol and vitamin A in models that explore if an interaction between these
Retinoic acid and dexamethasone affect RAR-β and surfactant protein C mRNA in the MLE lung cell line
Autor:
Mary A. Grummer, Richard D. Zachman
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 274:L1-L7
Lung development and surfactant biosynthesis are affected by retinoic acid (RA) and dexamethasone (Dex). Using a mouse lung epithelial cell line, we are exploring RA-Dex interactions through the study of RA and Dex effects on RA receptor (RAR) and su
Publikováno v:
The American Journal of Clinical Nutrition. 63:123-129
We tested the hypothesis that an intramuscular relative dose response (IM-RDR) on day 1 of life would more accurately predict which premature infants would develop bronchopulmonary dysplasia (BPD) than single measurements of retinol, retinyl palmitat
Autor:
Richard D. Zachman, Mary A. Grummer
Publikováno v:
Alcoholism: Clinical and Experimental Research. 19:1376-1381
The mechanism by which prenatal ethanol ingestion causes fetal alcohol syndrome (FAS) is unknown. We hypothesize that ethanol disrupts the normal function of retinoids in embryogenesis and differentiation, resulting in FAS. The present work was desig
Publikováno v:
Pediatric Research. 37:418-423
Ethanol consumption during pregnancy can cause fetal alcohol syndrome (FAS). Although the exact mechanism is unknown, nutritional alterations caused by ethanol exposure may be an etiologic factor in FAS. The congenital heart defects seen in FAS are s
Autor:
Richard D. Zachman, Kandi R. McMenamy
Publikováno v:
Pediatric Research. 33:251-255
Retinol, or one of its metabolites such as retinoic acid (RA), is an important factor in the differentiation and maintenance of integrity of lung epithelium. Retinol deficiency in rats induces morphologic changes in respiratory tract epithelial cells
Autor:
Mary A. Grummer, Richard D. Zachman
Publikováno v:
Neurotoxicology and teratology. 22(6)
Fetal ethanol exposure has many detrimental effects on neural development, which possibly occurs through ethanol-induced disruption of the function of vitamin A. In LAN-5 neuroblastoma cells, retinol (10(-6) M) and retinoic acid (RA; 10(-5)-10(-6) M)